Hypertension

Sibai, Baha M.

doi:10.1016/b978-0-443-06930-7.50035-9

Cited by 5 publications

(6 citation statements)

References 251 publications

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“…13 One of these problems is the hematological changes which may add to the existing neonatal morbidities. There was significant increase in Hb level and RBCs count in the study neonates compared to controls (p=0.004, 0.001) respectively agreeing the results of Bolat et al, 14 where the risk of polycythemia was shown to be 12.6-fold higher in babies of hypertensive mothers compared to the general population, and it was proven that maternal hypertension constituted a significant risk for polycythemia independent of fetal. 14 No significant differences regarding MCV, MCH, and MCHC between patients and controls however, some authors growth.…”

Section: Discussionsupporting

confidence: 90%

“…There was significant increase in Hb level and RBCs count in the study neonates compared to controls (p=0.004, 0.001) respectively agreeing the results of Bolat et al, 14 where the risk of polycythemia was shown to be 12.6-fold higher in babies of hypertensive mothers compared to the general population, and it was proven that maternal hypertension constituted a significant risk for polycythemia independent of fetal. 14 No significant differences regarding MCV, MCH, and MCHC between patients and controls however, some authors growth. 13 It has been reported that normoblasts increase in babies of preeclamptic mothers and this is secondary to uteroplacental hypoperfusion reported high different results.…”

Section: Discussionsupporting

confidence: 90%

“…16 Leucopenia and neutropenia had been proved in many reports. 14,17,18 Several mechanisms has been postulated for explanation of leucopenia in that group of babies. Reduced levels of growth factors that are responsible for increase neutrophil production together with presence of inhibitors decrease neutrophil production.…”

Section: Discussionmentioning

confidence: 99%

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Assessment of the hematological profile in neonates borne to sever pre eclamptic mothers (single center study)

Abdalla¹,

Sayed²

2018

IPCB

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Background: Preclampsia is a common disease unique to human pregnancy representing a challenge to obstetricians and neonatologists because of its serious effects on the mothers and babies. We aimed to evaluate hematological and coagulation aspects in newborns of preeclamptic mothers Patients and methods: Sixty (30 full and 30 preterm) neonates delivered to hypertensive mothers and another 30(15 full term and 15 preterm) babies of healthy normotensive mothers were as controls were enrolled. Detailed history taking and full clinical examination were done stressing on parity, mode of delivery, birth weight, APGAR score at o and five minutes and gestational age. All enrolled neonates were subjected to complete blood count (hb,ht,mcv, mch, wbcs, plates), pt, pc and ptt. Results:In full term babies of preeclamptic mothers, primigravida were 70% compared to 20% in controls while In preterm group, prmigravida mothers were 80% compared to 33.3% in controls (p=0.001). Cesarean section was the predominant mode of delivery in preterm neonates to preclamptic mothers (76.6% compared to 13.3% in controls while in full term group, cesarean section was 53.3 % compared to 86.3% for the controls. Sever preeclampsia comprised 80% of mothers of pre term infants versus 33.3% in mothers of term infants APGAR score was lower in infant of preclamptic mothers. RBCs number were and hemoglobin levels were significantly higher in neonates of preclamptic mothers (either term or preterm) than the control (p=0.001) while WBCs were significantly lower in neonates of preclamptic mothers (10.7±2.1,10.8±2.2 and 13.1±1.9,13±1.7respectively) ( p=0.001).Platelets numbers were significantly low in cases (186.1 ±91.5, 133.7 ±58.9) and 223.1 ± 43.4 and 216.4±51.8. Coagulation profile is significantly impaired PT, PTT 28.03±6.9, 21.7±3.1in cases and 14.1±1.8 and13.4±1.5 in controls (p=0.001). Prothrombin concentration was significantly lawer in cases (43.21±78, 61±7.7) compared to controls (70±3.5, 74.2±1.9). Conclusion:Neonates borne to preeclamptic mothers are more susceptible to impaired global coagulation status which is more expressed in preterm babies.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 90%

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Assessment of the hematological profile in neonates borne to sever pre eclamptic mothers (single center study)

Abdalla¹,

Sayed²

2018

IPCB

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“…Late onset preeclampsia is considered a maternal condition; a result of an underlying maternal constitutional disorder, and is more often associated with normal placenta, larger placental volume, along with a normal fetal growth [ 1 ]. Preeclampsia when associated with placental hypoperfusion results in hypoxic response in developing fetus in the form of increased erythropoiesis and release of immature erythrocytes [ 2 ]. Several studies have shown an increased number of nucleated red blood cell (NRBC) counts in the cord blood of newborns of preeclamptic mothers [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Significance of Maternal and Cord Blood Nucleated Red Blood Cell Count in Pregnancies Complicated by Preeclampsia

Hebbar

Misha

Rai

2014

Journal of Pregnancy

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Objectives. To evaluate the effect of preeclampsia on the cord blood and maternal NRBC count and to correlate NRBC count and neonatal outcome in preeclampsia and control groups. Study Design. This is a prospective case control observational study. Patients and Methods. Maternal and cord blood NRBC counts were studied in 50 preeclamptic women and 50 healthy pregnant women. Using automated cell counter total leucocyte count was obtained and peripheral smear was prepared to obtain NRBC count. Corrected WBC count and NRBC count/100 leucocytes in maternal venous blood and in cord blood were compared between the 2 groups. Results. No significant differences were found in corrected WBC count in maternal and cord blood in cases and controls. Significant differences were found in mean cord blood NRBC count in preeclampsia and control groups (40.0 ± 85.1 and 5.9 ± 6.3, P = 0.006). The mean maternal NRBC count in two groups was 2.4 ± 9.0 and 0.8 ± 1.5, respectively (P = 0.214). Cord blood NRBC count cut off value ≤13 could rule out adverse neonatal outcome with a sensitivity of 63% and specificity of 89%. Conclusion. Cord blood NRBC are significantly raised in preeclampsia. Neonates with elevated cord blood NRBC counts are more likely to have IUGR, low birth weight, neonatal ICU admission, respiratory distress syndrome, and assisted ventilation. Below the count of 13/100 leucocytes, adverse neonatal outcome is quite less likely.

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“…Women with preeclampsia that develops at <37 weeks have worse perinatal outcomes than those who develop the disease at term. 19 The rates of fetal growth restriction, perinatal mortality, and placental abruption are usually increased when preeclampsia develops preterm, while women experiencing mild preeclampsia at term have similar outcomes compared to normotensive women. 20 In addition, women who develop severe preeclampsia in the first pregnancy and have preeclampsia in a subsequent pregnancy have an increased incidence of placental abruption, preterm delivery, fetal growth restriction, and perinatal mortality compared to women who remain normotensive 13 or compared to preeclampsia in nulliparous women.…”

Section: Rate and Risk Of Recurrence Of Diseasementioning

confidence: 99%

Single vs. Recurrent Episodes of Preeclampsia-population–based Epidemiological and Clinical Characteristics

Mastrolia

Taran

Kachko

et al. 2020

Maternal-Fetal Medicine

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Objective: The aims of this study were to determine the differences between women with single vs. recurrent episodes of preeclampsia in term of: (1) the outcome of the first pregnancy affected by preeclampsia; and (2) the perinatal outcomes of subsequent pregnancies.Methods: This population based retrospective cohort study included all multiparous patients with a singleton gestation who delivered at Soroka University Medical Center (Beer Sheva, Israel) from January 1988 until December 2012, meeting the inclusion criteria, those who had fetuses with chromosomal or anatomical abnormalities were exclude. Our cohort included 213,558 deliveries that met the inclusion criteria, of them 208,017 had normotensive pregnancies and 5541 had preeclampsia. The latter group was further divided into those who had a single episode of preeclampsia followed by normotensive gestations (n = 3879), and women who had recurrent preeclampsia (n = 1662). We used parametric and non-parametric statistics as appropriate.Results: (1) Women with recurrent preeclampsia had an increased rate of early ((130/1662) 7.8% vs. (171/3879) 4.4%, P < 0.001) and late ((268/1662) 16.1% vs. (438/3879) 11.3%, P < 0.001) preterm deliveries than a single episode of preeclampsia; (2) of interest, the rate of chronic hypertension is higher in the first pregnancy of those with a single preeclampsia episode (P < 0.001), while women with recurrent preeclampsia developed it in the subsequent gestations (P < 0.001); (3) the rate of small for gestational age neonates in the index pregnancy was higher in those with recurrent rather than a single episode of preeclampsia (single episode 450/3879,11.6%, recurrent preeclampsia 244/1662, 14.7%, P = 0.002); (4) patients with recurrent disease had an increased rate of cesarean deliveries in the subsequent pregnancies (P < 0.001); and (5) patients who developed severe preeclampsia in the subsequent gestations had lower mean birthweight (P < 0.001), a higher rate of perinatal mortality (P < 0.001), and a lower Apgar score at 1 and 5 minutes (P < 0.001), than those who developed mild preeclampsia in subsequent pregnancies, those with a single episode of preeclampsia and the control group. Conclusion:Recurrent preeclampsia increases the rate of pregnancy complications in the following gestations. Early onset preeclampsia at the index pregnancy of women with recurrent preeclampsia, is associated with increased risk for severe preeclampsia, placental abruption and perinatal mortality in subsequent pregnancies.

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Hypertension

Cited by 5 publications

References 251 publications

Assessment of the hematological profile in neonates borne to sever pre eclamptic mothers (single center study)

Assessment of the hematological profile in neonates borne to sever pre eclamptic mothers (single center study)

Significance of Maternal and Cord Blood Nucleated Red Blood Cell Count in Pregnancies Complicated by Preeclampsia

Single vs. Recurrent Episodes of Preeclampsia-population–based Epidemiological and Clinical Characteristics

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