Single vs. Recurrent Episodes of Preeclampsia-population–based Epidemiological and Clinical Characteristics

Mastrolia, Salvatore Andrea; Taran, Boris; Kachko, Eric; Mor, Omer; Beer-Wiesel, Ruth; Eshkoli, Tamar; Dukler, Doron; Miodownik, Shayna; Erez, Offer

doi:10.1097/fm9.0000000000000082

Cited by 4 publications

(3 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Adverse neonatal health outcomes associated with PE include periventricular or intraventricular hemorrhage or subdural and cerebral hemorrhage, hypoxic–ischemic encephalopathy or periventricular leukomalacia, stillbirth, and perinatal death [ 40 ], in many cases the iatrogenic results accompanying medically-indicated preterm delivery. Aside from the immediate health risks associated with a PE diagnosis (i.e., HELLP, eclampsia), individuals who have had PE are seven times more likely to have a recurrence of PE in subsequent pregnancies, particularly with early onset disease [ 42 ]. Further, these individuals are at increased risk for cardiovascular disease in later life, with some estimates indicating the average age of first cardiac events as early as 38 years of age [ 42 ].…”

Section: Preeclampsiamentioning

confidence: 99%

“…Aside from the immediate health risks associated with a PE diagnosis (i.e., HELLP, eclampsia), individuals who have had PE are seven times more likely to have a recurrence of PE in subsequent pregnancies, particularly with early onset disease [ 42 ]. Further, these individuals are at increased risk for cardiovascular disease in later life, with some estimates indicating the average age of first cardiac events as early as 38 years of age [ 42 ].…”

Section: Preeclampsiamentioning

confidence: 99%

See 1 more Smart Citation

Placental Mitochondrial Function and Dysfunction in Preeclampsia

Jahan

Vasam

Green

et al. 2023

IJMS

View full text Add to dashboard Cite

The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational parent/fetal exchange, and ultimately, fetal development and growth. Not surprisingly, in cases of placental dysfunction—where aspects of placental development or function become compromised—adverse pregnancy outcomes can result. One common placenta-mediated disorder of pregnancy is preeclampsia (PE), a hypertensive disorder of pregnancy with a highly heterogeneous clinical presentation. The wide array of clinical characteristics observed in pregnant individuals and neonates of a PE pregnancy are likely the result of distinct forms of placental pathology underlying the PE diagnosis, explaining why no one common intervention has proven effective in the prevention or treatment of PE. The historical paradigm of placental pathology in PE highlights an important role for utero–placental malperfusion, placental hypoxia and oxidative stress, and a critical role for placental mitochondrial dysfunction in the pathogenesis and progression of the disease. In the current review, the evidence of placental mitochondrial dysfunction in the context of PE will be summarized, highlighting how altered mitochondrial function may be a common feature across distinct PE subtypes. Further, advances in this field of study and therapeutic targeting of mitochondria as a promising intervention for PE will be discussed.

show abstract

Section: Preeclampsiamentioning

confidence: 99%

Section: Preeclampsiamentioning

confidence: 99%

Placental Mitochondrial Function and Dysfunction in Preeclampsia

Jahan

Vasam

Green

et al. 2023

IJMS

View full text Add to dashboard Cite

show abstract

“…Aside from the immediate health risks associated with a PE diagnosis (i.e. HELLP, eclampsia), individuals who have had PE are seven times more likely to have a recurrence of PE in subsequent pregnancies, particularly with early onset disease [37]. Further, these individuals are at increased risk for cardiovascular disease in later life, with some estimates indicating the average age of first cardiac events as early as 38 years of age [37].…”

Section: Preeclampsiamentioning

confidence: 99%

Placental Mitochondrial Function and Dysfunction in Preeclampsia

Jahan¹,

Vasam²,

Green³

et al. 2023

Preprint

View full text Add to dashboard Cite

The placenta is a vital organ of pregnancy, regulating adaptation to pregnancy, gestational-parent/fetal exchange and ultimately fetal development and growth. Not surprisingly, in cases of placental dysfunction - where aspects of placental development or function become compromised - adverse pregnancy outcomes can result. One common placenta-mediated disorder of pregnancy is preeclampsia (PE), a hypertensive disorder of pregnancy with a highly heterogeneous clinical presentation. The wide array of clinical characteristics observed in pregnant individuals and neonates of a PE pregnancy are likely the result of distinct forms of placental pathology underlying the PE diagnosis, explaining why no one common intervention has proven effective in the prevention or treatment of PE. The historical paradigm of placental pathology in PE highlights an important role for utero-placental malperfusion, placental hypoxia and oxidative stress, and a critical role for placental mitochondrial dysfunction in the pathogenesis and progression of the disease. In the current review, the evidence of placental mitochondrial dysfunction in the context of PE will be summarized, highlighting how altered mitochondrial function may be a common feature across distinct PE subtypes. Further, advances in this field of study and therapeutic targeting of mitochondria as a promising intervention for PE will be discussed.

show abstract

Common pathogenesis of early and late preeclampsia: evidence from recurrences and review of the literature

Arbuzova

2023

Arch Gynecol Obstet

View full text Add to dashboard Cite

Objective To investigate whether there is an association between the gestational age at the onset of preeclampsia in recurrent cases and the gestational age at the onset of preeclampsia in previous pregnancies. Methods This retrospective nested case–control study was designed to investigate whether gestational age at diagnosis and at delivery in recurrent cases of preeclampsia correlates with gestational age at diagnosis and delivery in the previous cases of preeclampsia in the same individuals. The database of a Ukrainian research network was used to find patients with the diagnosis of preeclampsia between 2019 and 2021. The database was further queried to identify those with a history of preeclampsia in a previous pregnancy. The comparison was made using the Pearson correlation coefficient. Results One hundred and three patients who were diagnosed with preeclampsia were identified. Of those, 15 had recurrent preeclampsia, 2 of whom had preeclampsia in 2 previous pregnancies. There was no statistically significant correlation: based on gestational age at delivery R = − 0.28 (P = 0.30; 95% confidence interval (− 0.69 to 0.28) and based on gestational age at the time of diagnosis R = − 0.14 (P = 0.62; − 0.60 to 0.41). Conclusion Our data do not find an association between the gestational age of recurrent preeclampsia and preeclampsia diagnosed in a previous pregnancy. This supports the idea that there is single pathogenesis for preeclampsia regardless of the gestational age. It suggests that there are variations in the course of preeclampsia that may be determined by the capacity of the compensatory mechanisms.

show abstract

Single vs. Recurrent Episodes of Preeclampsia-population–based Epidemiological and Clinical Characteristics

Cited by 4 publications

References 29 publications

Placental Mitochondrial Function and Dysfunction in Preeclampsia

Placental Mitochondrial Function and Dysfunction in Preeclampsia

Placental Mitochondrial Function and Dysfunction in Preeclampsia

Common pathogenesis of early and late preeclampsia: evidence from recurrences and review of the literature

Contact Info

Product

Resources

About