Hyperparathyroidism and Metabolic Acidosis

Arruda, José A.L.; Kurtzman, Neil A.

doi:10.1159/000181941

Cited by 16 publications

(1 citation statement)

References 14 publications

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“…Studies of the effect of acidosis on PTH levels often have failed to provide consistent results. A major problem would seem that it is important to separate the results in acute from chronic acidosis in which compensatory changes occur (11,29,30) . In acute Met Acid, rapid changes in ionized calcium are observed that may affect the PTH response.…”

Section: Discussionmentioning

confidence: 99%

Direct Effect of Acute Metabolic and Respiratory Acidosis on Parathyroid Hormone Secretion in the Dog

López

Aguilera–Tejero

Felsenfeld

et al. 2002

J of Bone & Mineral Res

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Because both metabolic (Met Acid) and respiratory acidosis (Resp Acid) have diverse effects on mineral metabolism, it has been difficult to establish whether acidosis directly affects parathyroid hormone (PTH) secretion. Our goal was to determine whether acute Met Acid and Resp Acid directly affected PTH secretion. Three groups of dogs were studied: control, acute Met Acid induced by HCl infusion, and acute Resp Acid induced by hypoventilation. EDTA was infused to prevent acidosis-induced increases in ionized calcium, but more EDTA was needed in Met Acid than in Resp Acid. The PTH response to EDTA-induced hypocalcemia was evaluated also. Magnesium needed to be infused in groups receiving EDTA to prevent hypomagnesemia. The half-life of intact PTH (iPTH) was determined during hypocalcemia when PTH was measured after parathyroidectomy. During normocalcemia, PTH values were greater (p < 0.05) in Met Acid (92 ؎ 19 pg/ml) and Resp Acid (77 ؎ 22 pg/ml) than in controls (27 ؎ 5 pg/ml); the respective pH values were 7.23 ؎ 0.01, 7.24 ؎ 0.01, and 7.39 ؎ 0.02. The maximal PTH response to hypocalcemia was greater (p < 0.05) in Met Acid (443 ؎ 54 pg/ml) than in Resp Acid (267 ؎ 37 pg/ml) and controls (262 ؎ 48 pg/ml). The half-life of PTH was greater (p < 0.05) in Met Acid than in controls, but the PTH secretion rate also was greater (p < 0.05) in Met Acid than in the other two groups. In conclusion, (

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Section: Discussionmentioning

confidence: 99%

Direct Effect of Acute Metabolic and Respiratory Acidosis on Parathyroid Hormone Secretion in the Dog

López

Aguilera–Tejero

Felsenfeld

et al. 2002

J of Bone & Mineral Res

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Renal Tubular Acidosis

Rodríguez‐Soriano¹

1981

Pediatric Nephrology

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Relationship between metabolic acidosis and calcium phosphate urinary stone formation in women

Kohri

Kodama

Ishikawa

et al. 1991

International Urology and Nephrology

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The relationship between the degree of metabolic acidosis and calcium phosphate stone formation was studied. Furthermore, the reasons why renal tubular acidosis (RTA) and primary hyperparathyroidism (PHPT) dominantly occur in women, and female stone formers more often produce calcium phosphate stone are discussed. Blood was slightly more acidotic in women than in men in both the urolithiasis and the control groups. Likewise, blood was significantly more acidotic and urinary pH significantly higher in patients with PHPT. Patients with RTA had severe metabolic acidosis, and urinary pH was highest among all groups. Calcium phosphate concentration was significantly higher in women than in men, and was also higher in patients with PHPT than in those with urolithiasis. All patients with RTA had pure calcium phosphate stones. The reasons why females are more acidotic and have more calcium phosphate in stones are suspected to be related to progesterone and urinary tract infection.

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Hyperparathyroidism and Metabolic Acidosis

Cited by 16 publications

References 14 publications

Direct Effect of Acute Metabolic and Respiratory Acidosis on Parathyroid Hormone Secretion in the Dog

Direct Effect of Acute Metabolic and Respiratory Acidosis on Parathyroid Hormone Secretion in the Dog

Renal Tubular Acidosis

Relationship between metabolic acidosis and calcium phosphate urinary stone formation in women

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