Direct Effect of Acute Metabolic and Respiratory Acidosis on Parathyroid Hormone Secretion in the Dog

López, Ignacio; Aguilera–Tejero, Escolástico; Felsenfeld, Arnold J.; Estepa, J. C.; Rodriguez, Mariano

doi:10.1359/jbmr.2002.17.9.1691

Cited by 53 publications

(54 citation statements)

References 46 publications

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“…As was shown previously (18), the increase in PTH values in the clamped groups during the induction of acute metabolic and respiratory acidosis was similar. In both conditions, a decrease in blood pH of ϳ0.10 units resulted in near-maximal PTH stimulation.…”

Section: Discussionsupporting

confidence: 88%

“…In both conditions, a decrease in blood pH of ϳ0.10 units resulted in near-maximal PTH stimulation. The acidosis-induced stimulation of PTH is approximately one-fourth of the maximal PTH stimulation seen with hypocalcemia (1,10,18,23).…”

Section: Discussionmentioning

confidence: 99%

“…During the 60-min study, blood was drawn at 10-min intervals. Results from dogs in the two clamped groups have been reported previously (18).…”

Section: Animalsmentioning

confidence: 91%

“…Five groups of dogs were studied: control, metabolic acidosis with and without calcium clamp, and respiratory acidosis with and without calcium clamp. Details on the care, feeding, medications, sedation, placement of intravenous catheters, intubation, anesthesia, ventilation, and blood pressure monitoring are provided in a recent publication (18).…”

Section: Animalsmentioning

confidence: 99%

“…We recently showed that both acute metabolic acidosis and respiratory acidosis increase PTH secretion (18). To determine the specific effect of acute metabolic and respiratory acidosis on PTH secretion, the ionized calcium concentration was clamped at a normal value.…”

mentioning

confidence: 99%

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Role of acidosis-induced increases in calcium on PTH secretion in acute metabolic and respiratory acidosis in the dog

López¹,

Aguilera–Tejero²,

Estepa³

et al. 2004

American Journal of Physiology-Endocrinology and Metabolism

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of acidosis-induced increases in calcium on PTH secretion in acute metabolic and respiratory acidosis in the dog. Am J Physiol Endocrinol Metab 286: E780 -E785, 2004. First published January 13, 2004 10.1152/ajpendo.00473.2003.-Recently, we showed that both acute metabolic acidosis and respiratory acidosis stimulate parathyroid hormone (PTH) secretion in the dog. To evaluate the specific effect of acidosis, ionized calcium (iCa) was clamped at a normal value. Because iCa values normally increase during acute acidosis, we now have studied the PTH response to acute metabolic and respiratory acidosis in dogs in which the iCa concentration was allowed to increase (nonclamped) compared with dogs with a normal iCa concentration (clamped). Five groups of dogs were studied: control, metabolic (clamped and nonclamped), and respiratory (clamped and nonclamped) acidosis. Metabolic (HCl infusion) and respiratory (hypoventilation) acidosis was progressively induced during 60 min. In the two clamped groups, iCa was maintained at a normal value with an EDTA infusion. Both metabolic and respiratory acidosis increased (P Ͻ 0.05) iCa values in nonclamped groups. In metabolic acidosis, the increase in iCa was progressive and greater (P Ͻ 0.05) than in respiratory acidosis, in which iCa increased by 0.04 mM and then remained constant despite further pH reductions. The increase in PTH values was greater (P Ͻ 0.05) in clamped than in nonclamped groups (metabolic and respiratory acidosis). In the nonclamped metabolic acidosis group, PTH values first increased and then decreased from peak values when iCa increased by Ͼ0.1 mM. In the nonclamped respiratory acidosis group, PTH values exceeded (P Ͻ 0.05) baseline values only after iCa values stopped increasing at a pH of 7.30. For the same increase in iCa in the nonclamped groups, PTH values increased more in metabolic acidosis. In conclusion, 1) both metabolic acidosis and respiratory acidosis stimulate PTH secretion; 2) the physiological increase in the iCa concentration during the induction of metabolic and respiratory acidosis reduces the magnitude of the PTH increase; 3) in metabolic acidosis, the increase in the iCa concentration can be of sufficient magnitude to reverse the increase in PTH values; and 4) for the same degree of acidosis-induced hypercalcemia, the increase in PTH values is greater in metabolic than in respiratory acidosis.hypercalcemia; metabolic acidosis; parathyroid hormone; respiratory acidosis BESIDES ITS WELL-KNOWN EFFECT on calcium homeostasis, parathyroid hormone (PTH) has also been associated with changes in the acid-base status. In 1970, Wills (26) suggested that PTH-induced bone resorption mobilized phosphate to act as a buffer to neutralize acidosis. In subsequent studies, PTH administration has been shown to increase net acid excretion (14, 24) and induce metabolic alkalosis in dogs and humans by both renal and extrarenal mechanisms (15-17). Because PTH appears to have a role in acid-base homeostasis, it would seem reasonable that acid-base disorders may...

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

“…During the 60-min study, blood was drawn at 10-min intervals. Results from dogs in the two clamped groups have been reported previously (18).…”

Section: Animalsmentioning

confidence: 91%

Section: Animalsmentioning

confidence: 99%

mentioning

confidence: 99%

See 3 more Smart Citations

Role of acidosis-induced increases in calcium on PTH secretion in acute metabolic and respiratory acidosis in the dog

López¹,

Aguilera–Tejero²,

Estepa³

et al. 2004

American Journal of Physiology-Endocrinology and Metabolism

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Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses

Kohrt

Wherry

Wolfe

et al. 2018

Journal of Bone and Mineral Research

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Exercise can cause a decrease in serum ionized calcium (iCa) and increases in parathyroid hormone (PTH) and bone resorption. We used a novel intravenous iCa clamp technique to determine whether preventing a decline in serum iCa during exercise prevents increases in PTH and carboxy-terminal collagen crosslinks (CTX). Eleven cycling-trained men (aged 18 to 45 years) underwent two identical 60-min cycling bouts with infusion of Ca gluconate or saline. Blood sampling for iCa, total calcium (tCa), PTH, CTX, and procollagen type 1 amino-terminal propeptide (P1NP) occurred before, during, and for 4 hours after exercise; results are presented as unadjusted and adjusted for plasma volume shifts (denoted with subscript ADJ). iCa decreased during exercise with saline infusion (p = 0.01 at 60 min) and this was prevented by Ca infusion (interaction, p < 0.007); there were abrupt decreases in Ca content (iCa and tCa ) in the first 15 min of exercise under both conditions. PTH and CTX were increased at the end of exercise (both p < 0.01) on the saline day, and markedly attenuated (-65% and -71%; both p < 0.001) by Ca. CTX remained elevated for 4 hours after exercise on the saline day (p < 0.001), despite the return of PTH to baseline by 1 hour after exercise. P1NP increased in response to exercise (p < 0.001), with no difference between conditions, but the increase in P1NP was not significant. Results for PTH and CTX were similar to unadjusted results. These findings demonstrate that bone resorption is stimulated early in exercise to defend serum iCa. Vascular Ca content decreased early in exercise, but neither the reason why this occurred, nor the fate of Ca, are known. The results suggest that the exercise-induced increase in PTH had an acute catabolic effect on bone. Future research should determine whether the increase in PTH generates an anabolic response that occurs more than 4 hours after exercise. © 2018 American Society for Bone and Mineral Research.

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Nebenschilddrüse

Schäffler¹,

Bollheimer²,

Büttner³

et al. 2012

Funktionsdiagnostik in Endokrinologie, Diabetologie Und Stoffwechsel

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Direct Effect of Acute Metabolic and Respiratory Acidosis on Parathyroid Hormone Secretion in the Dog

Cited by 53 publications

References 46 publications

Role of acidosis-induced increases in calcium on PTH secretion in acute metabolic and respiratory acidosis in the dog

Role of acidosis-induced increases in calcium on PTH secretion in acute metabolic and respiratory acidosis in the dog

Maintenance of Serum Ionized Calcium During Exercise Attenuates Parathyroid Hormone and Bone Resorption Responses

Nebenschilddrüse

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