Hyperlipidemia in Stroke Pathobiology and Therapy: Insights and Perspectives

Menet, Romain; Bernard, Maxime; ElAli, Ayman

doi:10.3389/fphys.2018.00488

Cited by 48 publications

(39 citation statements)

References 50 publications

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“…Hypertension, diabetes, hyperlipidemia, chronic obstructive pulmonary disease, end stage renal disease, and atrial fibrillation are thought to be the independent risk factors for IS with 2-to 3-fold increased risk in stroke (Boehme et al, 2017). Possible mechanisms leading to stroke are chronic systemic inflammation (Austin et al, 2016;Chen R. et al, 2016;Jimenez et al, 2016;Nayak-Rao and Shenoy, 2017;Menet et al, 2018). Inflammation plays an important role in the development of the atherosclerotic plaque and the main pathologic process of IS.…”

Section: Discussionmentioning

confidence: 99%

Adjunctive Chinese Herbal Products Therapy Reduces the Risk of Ischemic Stroke Among Patients With Rheumatoid Arthritis

2020

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We performed a retrospective cohort study to investigate the association between the risk of ischemic stroke (IS) and the use of Chinese herbal products (CHP) in combination with western medicine (WM) among patients with rheumatoid arthritis (RA). The data were sourced from the registry for beneficiaries, inpatient and ambulatory care claims, and Registry for Catastrophic Illness from the National Health Insurance Research Database (NHIRD) in Taiwan between 1997 and 2011. Patients, who were newly diagnosed with RA between 1997 and 2010, were classified as the CHP group or non-CHP group depending on the presence of absence the adjunctive use of CHP following a diagnosis of RA. A total of 4,148 RA patients were in both the CHP and non-CHP groups after 1:1 matching. Patients in the CHP group had a significantly lower risk of IS compared to patients in the non-CHP group (adjusted hazard ratio [aHR], 0.67; 95% confidence interval [CI], 0.52-0.86). In the CHP group, patients who used CHP for more than 30 days had a lower risk of IS than their counterparts (aHR: 0.61, 95% CI: 0.40-0.91). Gui-Zhi-Shao-Yao-Zhi-Mu-Tang, Shu-Jin-Huo-Xie-Tang, and Du-Huo-Ji-Sheng-Tang might be associated with a lower risk of IS. Finally, the use of CHP in combination with WM was associated with a decreased risk of IS in patients with RA, especially among those who had used CHP for more than 30 days. A further randomized control trial is required to clarify the casual relationship between these results.

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Section: Discussionmentioning

confidence: 99%

Adjunctive Chinese Herbal Products Therapy Reduces the Risk of Ischemic Stroke Among Patients With Rheumatoid Arthritis

2020

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“…When the values of one or both of the triglycerides and total cholesterol in the blood exceed the normal values, it is called hyperlipidemia. Hyperlipidemia is also closely related to many diseases, such as stroke, hypertension, diabetes, kidney disease, and other chronic diseases [ 18 , 19 ]. As the cholesterol (especially bad cholesterol) or triglyceride concentration increases, it can cause the abnormal function of vascular endothelial cells.…”

Section: Lipid-induced Cardiac Tissue Damagementioning

confidence: 99%

Effects of Lipids and Lipoproteins on Mesenchymal Stem Cells Used in Cardiac Tissue Regeneration

Lin

Kang

Feng

et al. 2020

IJMS

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Mesenchymal stem cells (MSCs) have two characteristics of interest for this paper: the ability to self-renew, and the potential for multiple-lineage differentiation into various cells. MSCs have been used in cardiac tissue regeneration for over a decade. Adult cardiac tissue regeneration ability is quite low; it cannot repair itself after injury, as the heart cells are replaced by fibroblasts and lose function. It is therefore important to search for a feasible way to repair and restore heart function through stem cell therapy. Stem cells can differentiate and provide a source of progenitor cells for cardiomyocytes, endothelial cells, and supporting cells. Studies have shown that the concentrations of blood lipids and lipoproteins affect cardiovascular diseases, such as atherosclerosis, hypertension, and obesity. Furthermore, the MSC lipid profiles, such as the triglyceride and cholesterol content, have been revealed by lipidomics, as well as their correlation with MSC differentiation. Abnormal blood lipids can cause serious damage to internal organs, especially heart tissue. In the past decade, the accumulated literature has indicated that lipids/lipoproteins affect stem cell behavior and biological functions, including their multiple lineage capability, and in turn affect the outcome of regenerative medicine. This review will focus on the effect of lipids/lipoproteins on MSC cardiac regenerative medicine, as well as the effect of lipid-lowering drugs in promoting cardiomyogenesis-associated MSC differentiation.

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“…It also instigates inflammatory cascades in form of endothelial cell activation, and infiltration of the circulating immune cells into the brain, platelet activation and adhesion to the injured endothelial cells. 16…”

Section: Hyperlipedemia In Cva: Mechanismmentioning

confidence: 99%

A cross-sectional study of impact of dyslipidemia in stroke

et al. 2020

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Background: Stroke is defined as abrupt onset of symptoms and/or sign of focal and global loss of cerebral function lasting for at least 24 hrs with no apparent cause other than of vascular origin. Dyslipidemia in stroke is not widely studied especially from the population of Northeast India (Manipur). Moreover, most prior studies did not specifically compare hemorrhagic stroke risk among those with elevated lipid levels to those with optimal or near optimal lipid levels. Therefore, we studied the levels of different Lipids in stroke patients (hemorrhagic and ischemic) to understand its role in pathogenesis of stroke. Methods: This cross-sectional study was conducted in RIMS, Manipur from 2017-2019 and included 185 patients above 18 years with stroke within 48 hrs of onset of symptoms. NCCT brain and serum lipids, other related blood investigations were performed.Results: We found that serum total cholesterol, LDL-C and triglycerides are significantly higher in infarction patients with average levels of 210.82 mg/dl, 143.64 mg/dl and 151.50 mg/dl respectively which is statistically significant (p<0.001). The average serum total cholesterol, LDL-C and triglycerides are significantly lower in ICH patients with average levels of 143.34 mg/dl, 84.67 mg/dl and 113.94 mg/dl respectively which is statistically significant. (p<0.001).Conclusions: We concluded that raised level of serum total cholesterol, serum LDL-C, serum triglyceride are associated with cerebral infraction (p=0.001) and lower level of serum total cholesterol, serum LDL-C, serum triglyceride are associated with cerebral hemorrhage (p=0.001). Thus, serum lipid levels should be carefully monitored to prevent life threatening stroke.

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Hyperlipidemia in Stroke Pathobiology and Therapy: Insights and Perspectives

Cited by 48 publications

References 50 publications

Adjunctive Chinese Herbal Products Therapy Reduces the Risk of Ischemic Stroke Among Patients With Rheumatoid Arthritis

Adjunctive Chinese Herbal Products Therapy Reduces the Risk of Ischemic Stroke Among Patients With Rheumatoid Arthritis

Effects of Lipids and Lipoproteins on Mesenchymal Stem Cells Used in Cardiac Tissue Regeneration

A cross-sectional study of impact of dyslipidemia in stroke

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