Hyperlipidemia and hyper glycaemia in Breast Cancer Patients is related to disease stage

Raza, Uzma; Asif, Mahay Rookh; Rehman, Asif Bin; Sheikh, Aminuddin

doi:10.12669/pjms.341.14841

Cited by 18 publications

(19 citation statements)

References 21 publications

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“…This conclusion comes from the high cholesterol levels in BC patients. Current study supports earlier findings that associated elevated T. chol with BC, 34,35 and patients diagnosed with lymph node metastasis were found to show significantly elevated T. chol when compared with those without lymph node involvement. 34 Contrary, T. chol level was strongly and negatively correlated with BC.…”

Section: Discussionsupporting

confidence: 92%

High atherogenic index of plasma and cardiovascular risk factors among Ghanaian breast cancer patients

Tagoe

Dwamena-Akoto

Nsaful

et al. 2020

Exp Biol Med (Maywood)

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Comorbidities impact negatively on breast cancer prognosis, especially in developing countries where cases are usually presented to clinics at advanced stages. This study aimed to determine the atherogenic index of plasma (AIP) and cardiovascular risk factors among Ghanaian women diagnosed with breast cancer. A total of 52 breast cancer patients were age-matched with 52 healthy controls. Sociodemographics of participants were obtained using a well-structured questionnaire. Pathological data of patients were obtained from medical records, and all clinical and anthropometric measurements were done using standard instruments. Lipid profile was determined from serum using enzymatic assays, and cardiovascular risk factors were calculated from estimated lipid parameters. Blood pressure, AIP, total cholesterol (T. chol), triglyceride (TG), and low-density lipoprotein cholesterol (LDL-c) were significantly elevated ( P < 0.05) in the breast cancer patients compared to the controls, but the reverse was observed for high-density lipoprotein cholesterol (HDL-c) ( P < 0.01). Obesity (odds ratio [OR] = 2.51, P = 0.015), hypertension (OR = 4.04, P < 0.001), AIP (OR = 10.44, P < 0.001), and dyslipidemia ( P < 0.01) were significantly associated with breast cancer. AIP correlated positively with age (r = 0.244, P < 0.05), body mass index (r = 0.225, P < 0.05), blood pressure ( P < 0.01), T. chol (r =0.418, P< 0.01), and TG (r = 0.880, P < 0.01), but inversely correlated with HDL-c (r = −0.460, P < 0.01). A greater proportion (88%) of the patients presented with advanced breast cancer. AIP and cardiovascular risk factors were high in the breast cancer patients. Considering that AIP and cardiovascular disease risk factors are of interest in breast cancer patients, further studies are needed to understand the effect of AIP and cardiovascular risk factors on breast cancer outcomes. Impact statement Breast cancer prognosis is negatively impacted by comorbidities, especially in global regions where patients present to clinics with advanced cancer stages. This study reports preliminary findings on atherogenic index of plasma (AIP) and cardiovascular risk factors in Ghanaian breast cancer patients. AIP and cardiovascular risk factors were identified to be high in the breast cancer patients and therefore should be of prime interest to warrant further studies. Ultimately, understanding the contribution of AIP and cardiovascular risk factors in breast cancer will impact positively on clinical management of patients with breast cancer.

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Section: Discussionsupporting

confidence: 92%

High atherogenic index of plasma and cardiovascular risk factors among Ghanaian breast cancer patients

Tagoe

Dwamena-Akoto

Nsaful

et al. 2020

Exp Biol Med (Maywood)

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“…One longitudinal analysis showed that hyperlipidemia was significantly higher in breast cancer patients with lymph node metastasis. The severity of hyperlipidemia was found to differ in proportion to tumor size and grade [30]. In addition, obesity has also been associated with various types of cancers, including breast cancer [31].…”

Section: Discussionmentioning

confidence: 99%

Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study

et al. 2020

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Background and objectives: Breast cancer is a common cancer in women and has been the fourth leading cause of death in Taiwanese women. Risk factors for breast cancer include family history of breast cancer, genetic factors, and not breastfeeding. Several studies have reported an association between repeated inflammation at a young age, especially among lactating women, and cancer; however, the number of studies about the association of mastitis and breast cancer in nonlactating women is still limited. Therefore, the aim of this study was to determine the relationship between mastitis in women aged ≥40 years and breast cancer. Materials and Methods: This was a retrospective cohort study design. The data source was the Longitudinal Health Insurance Database 2010 (LHID 2010), comprising data collected by Taiwan’s National Health Insurance program. Cases of newly diagnosed mastitis in women aged ≥40 years (ICD-9-CM code = 611.0) were selected from the years 2010 to 2012. Women not diagnosed with mastitis were selected as the control group, and their data for the years 2009 to 2013 were obtained through the database. In addition, the non-mastitis group was matched 1:10 by age. Results: A total of 8634 participants were selected from the LHID 2010, which included 734 cases with mastitis and 7900 cases without mastitis. After adjustment for age, hypertension, hyperlipidemia, diabetes, hypothyroidism, and autoimmune diseases, the Cox proportional hazard model showed that patients with mastitis had a higher risk of breast cancer (aHR = 3.71, 95% CI = 1.9–7.02) compared with the non-mastitis group. The Kaplan–Meier curve also showed that women with mastitis had a higher risk of developing breast cancer. Conclusions: This study confirmed that women with mastitis have a higher risk of developing breast cancer. Therefore, women aged ≥40 years could reduce breast cancer risk by taking precautions to prevent mammary gland infection and mastitis.

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“…Hyperlipidemia is an umbrella term that refers to conditions associated with levels of lipid (free fatty acids (FFA), cholesterol, and triglycerides) circulating in the blood that is persistently elevated above baseline. In cancer, hyperlipidemia has been reported in human cancers [ 57 , 58 , 59 , 60 ] and pre-clinical cancer models [ 40 , 43 , 61 , 62 , 63 , 64 , 65 ]. Cancer-associated hyperlipidemia is likely caused by accelerated lipolysis in adipose tissue due to the upregulation of the key lipolytic enzymes, AGTL and HSL in both humans [ 61 , 66 ] and rodent pre-clinical models [ 61 ].…”

Section: Potential Mechanism Underlying Cancer-associated Metabolimentioning

confidence: 99%

Exercise—A Panacea of Metabolic Dysregulation in Cancer: Physiological and Molecular Insights

Raun

Buch-Larsen

Schwarz

et al. 2021

IJMS

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Metabolic dysfunction is a comorbidity of many types of cancers. Disruption of glucose metabolism is of concern, as it is associated with higher cancer recurrence rates and reduced survival. Current evidence suggests many health benefits from exercise during and after cancer treatment, yet only a limited number of studies have addressed the effect of exercise on cancer-associated disruption of metabolism. In this review, we draw on studies in cells, rodents, and humans to describe the metabolic dysfunctions observed in cancer and the tissues involved. We discuss how the known effects of acute exercise and exercise training observed in healthy subjects could have a positive outcome on mechanisms in people with cancer, namely: insulin resistance, hyperlipidemia, mitochondrial dysfunction, inflammation, and cachexia. Finally, we compile the current limited knowledge of how exercise corrects metabolic control in cancer and identify unanswered questions for future research.

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Hyperlipidemia and hyper glycaemia in Breast Cancer Patients is related to disease stage

Cited by 18 publications

References 21 publications

High atherogenic index of plasma and cardiovascular risk factors among Ghanaian breast cancer patients

High atherogenic index of plasma and cardiovascular risk factors among Ghanaian breast cancer patients

Risk of Breast Cancer in Women with Mastitis: A Retrospective Population-Based Cohort Study

Exercise—A Panacea of Metabolic Dysregulation in Cancer: Physiological and Molecular Insights

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