Hyperimmunoglobulin E syndrome: Two cases and a review of the literature

DeWitt, Christine A.; Bishop, Amanda B.; Buescher, Lucinda; Stone, Stephen

doi:10.1016/j.jaad.2005.10.022

Cited by 55 publications

(93 citation statements)

References 72 publications

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“…D'un point de vue morphologique, les manifestations sont surtout faciales : asymétrie faciale avec hémihypertrophie, aplatissement de la base du nez, front proéminant [2,4,9], telles que rapportées dans le cas présent. Elles se développent précocement dès l'enfance.…”

Section: Discussionunclassified

“…D'autres signes squelettiques inconstants sont rapportés, tels une synostose crânienne précoce, une ostéoporose et une ostéogenèse imparfaite provoquant des fractures fréquentes des os longs, une scoliose [2].…”

Section: Discussionunclassified

“…Moins fréquemment, on retrouve, comme dans le cas présent, des ulcérations au niveau de la face dorsale de la langue. Les espèces bactériennes incriminées sont les staphylocoques aureus dans 60 % des cas, Hemophilus influenzae dans 10 % des cas et, peu fréquemment, Streptoccoccus pneumoniae, Cryptococcus neoformans, Aspergillus fumigatus [2]. Le traitement repose alors par une antibiothérapie à large spectre.…”

Section: Discussionunclassified

“…C'est en 1973 que Clark, puis en 1974 que Hill montrent que ces deux syndromes initialement décrits reposent sur un défaut du chimiotactisme des polynucléaires neutrophiles. Rapidement, ils furent regroupés sous le terme de syndrome d'hyperimmunoglobulinémie E (HIES) et depuis 250 cas ont été décrits dans la littérature [2]. L'HIES est défini par un ensemble de signes cliniques associant des infections sévères et récidivantes de la peau (abcès froids) et du tractus sinopulmonaire (essentiellement staphylococciques), une dermatose chronique eczématiforme et un début précoce de la maladie (premiers mois voire premières années de la vie).…”

Section: Introductionunclassified

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Le syndrome de Job-Buckley : à propos d’un cas et revue de la littérature

Ikiss¹,

Alaoui²

2015

Med Buccale Chir Buccale

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Section: Discussionunclassified

Section: Introductionunclassified

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Le syndrome de Job-Buckley : à propos d’un cas et revue de la littérature

Ikiss¹,

Alaoui²

2015

Med Buccale Chir Buccale

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“…HIES has an incidence of 1 in 500,000 live births 7 and occurs in both males and females of all ethinic groups with equal frequency 8 . Type 1 is a dominant form caused by heterozygous muta ons in the transcrip on factor STAT3 involving skin, connec ve ssue, skeleton and characteris c facial appearance.…”

Section: Discussionmentioning

confidence: 99%

Atopic Dermatitis or Hyper IgE Syndrome?

Ahmed¹,

Kumar

Raj

2015

J. Nepal Paedtr. Soc.

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Eczema and skin infections are commonly encountered in children in the outpatient department. However, presence of both recurrent dermatitis and skin infections should alarm one to consider Hyper IgE syndrome (HIES) as a differential. Here we present a case of HIES in a two and a half year old female child with history of recurrent dermatitis and skin infections in the form of cold abscesses. Laboratory investigations showed markedly elevated IgE levels and high absolute eosinophils counts. Patient was treated with trimethoprim-sulfamethoxazole and supportive care. The current report highlights the fact that HIES can present in early childhood with just skin manifestations and without any significant pulmonary manifestations.

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Biosensors, Aptamers (Aptasensors)

Bini

Mascini

Turner

2010

Encyclopedia of Industrial Biotechnology

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Aptamers are single‐stranded DNA or RNA ligands which can be selected for different targets, starting from a huge library of molecules containing randomly created sequences. Aptamers have been selected to bind very different targets, from proteins to small organic dyes. The different fields of analytical chemistry, when dealing with systems based on biomolecular interactions, are still dominated by immunoassays, but detailed analytical studies are now demonstrating that some of the limitations of these conventional assays can be circumvented by alternative recognition reagents such as aptamers. Aptamers have been extensively used in many analytical applications such as chromatography, electrophoresis, mass spectrometry, molecular beacons, sensors and biosensors. This chapter focuses on the particular case of biosensors employing aptamers as new biorecognition elements, which are known as “aptasensors”. This chapter describes the specific features of aptamers and reports on their employment for the development of aptasensors, especially as applied to the detection of clinically‐relevant proteins for diagnostic assays. However, the large variety of aptamers which have been selected to bind low molecular weight molecules leads to the possible use of these oligonucleotides in a wider range of applications such as assays for the analysis of environmental and food samples, as well as detection terrorist threat agents that are biological.

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Hyperimmunoglobulin E syndrome: Two cases and a review of the literature

Cited by 55 publications

References 72 publications

Le syndrome de Job-Buckley : à propos d’un cas et revue de la littérature

Le syndrome de Job-Buckley : à propos d’un cas et revue de la littérature

Atopic Dermatitis or Hyper IgE Syndrome?

Biosensors, Aptamers (Aptasensors)

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