Hyperglycosylated human chorionic gonadotropin and the source of pregnancy failures

Sasaki, Yasushi; Ladner, Donald G.; Cole, Laurence A.

doi:10.1016/j.fertnstert.2007.03.010

Cited by 116 publications

(101 citation statements)

References 35 publications

(79 reference statements)

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“…Research of the candidate signals implicates gestational human chorionic gonadotropin (hCG) in maternal serum as one component of the screen [5][6][7][8]. As early as the second week after fertilization, hCG promotes maintenance of the corpus luteum and stimulates progesterone secretion from the placenta; both processes prevent miscarriage [9].…”

Section: Introductionmentioning

confidence: 99%

A test of maternal human chorionic gonadotropin during pregnancy as an adaptive filter of human gestations

et al. 2012

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The risk of abnormalities and morbidity among live births increases with advanced maternal age. Explanations for this elevated morbidity invoke several maternal mechanisms. The relaxed filter stringency (RFS) hypothesis asserts that mothers, nearing the end of their reproductive lifespan, reduce the stringency of a screen of offspring quality in utero based on life-history traits of parity and interbirth interval (IBI). A separate line of research implicates human chorionic gonadotropin (hCG) during pregnancy as a signal of offspring quality. We test the RFS hypothesis directly by examining whether the difference in gestational hCG across consecutive live births varies positively with the mother's number of previous live births but inversely with her most recent IBI. We applied multivariable regression methods to a unique dataset of gestational hCG for over 500 000 live births from 2002 to 2007. The difference in gestational hCG across mothers' consecutive live births varies positively with both mothers' parity and IBI. These associations remain similar among older mothers (35þ years). Findings support the RFS hypothesis for the parity expectation but not for the IBI expectation. Further evidence for the RFS hypothesis among contemporary human gestations would have to invoke screening mechanisms other than hCG.

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Section: Introductionmentioning

confidence: 99%

A test of maternal human chorionic gonadotropin during pregnancy as an adaptive filter of human gestations

et al. 2012

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“…A deficiency of hCG-2 does quite commonly occur. It causes pregnancy failure at implantation, and preeclampsia and hypertension in the second and third trimesters of pregnancy [36][37][38][39]. Table 3 shows urine samples and concentrations of hCG-1 and hCG-2 in 93 women on the first possible day of hCG detection or implantation of pregnancy.…”

Section: Hcg-1 -Hcg-5 Production and Occurrencementioning

confidence: 99%

hCG, Hyperglycosylated hCG, Pituitary hCG, Cancer hCG and Fetal hCG

Cole¹

2015

J Preg Child Health

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“…The autocrine hyperglycosylated hCG controls pregnancy implantation at the start of gestation [20,21]. It controls deep implantation of hemochorial placentation at the end of the first trimester of pregnancy [22], controls placenta growth during pregnancy [23] and controls malignancy by all human cancer cells [24,25].…”

Section: Introductionmentioning

confidence: 99%

The Minute Structural Difference between the Hormone hCG and the Autocrine Hyperglycosylated hCG

Cole¹

2017

J Glycobiol

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Introduction: In 1997 I discovered hyperglycosylated hCG, a separate and independent molecule to the hormone hCG. The structure of hyperglycosylated hCG was also examined, it was a molecule varying from hCG by just 3 or 4 small sugar side chains, or 2.8% of molecular weight. While the hormone hCG binds a luteinizing hormone (LH)/hCG hormone receptor, hyperglycosylated hCG and its β-subunit are autocrines binding and antagonizing a TGF-β-II receptor. Here structural differences between the two molecules are investigated.

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Hyperglycosylated human chorionic gonadotropin and the source of pregnancy failures

Cited by 116 publications

References 35 publications

A test of maternal human chorionic gonadotropin during pregnancy as an adaptive filter of human gestations

A test of maternal human chorionic gonadotropin during pregnancy as an adaptive filter of human gestations

hCG, Hyperglycosylated hCG, Pituitary hCG, Cancer hCG and Fetal hCG

The Minute Structural Difference between the Hormone hCG and the Autocrine Hyperglycosylated hCG

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