The Minute Structural Difference between the Hormone hCG and the Autocrine Hyperglycosylated hCG

Abstract

Introduction: In 1997 I discovered hyperglycosylated hCG, a separate and independent molecule to the hormone hCG. The structure of hyperglycosylated hCG was also examined, it was a molecule varying from hCG by just 3 or 4 small sugar side chains, or 2.8% of molecular weight. While the hormone hCG binds a luteinizing hormone (LH)/hCG hormone receptor, hyperglycosylated hCG and its β-subunit are autocrines binding and antagonizing a TGF-β-II receptor. Here structural differences between the two molecules are investigated.