Hypercholesterolemia as a Risk Factor for Deep-Vein Thrombosis

Kawasaki, Tomio; Kambayashi, Jun-ichi; Ariyoshi, Hideo; Sakon, Masato; Suehisa, Etsuji; Monden, Morito

doi:10.1016/s0049-3848(97)00192-8

Cited by 78 publications

(76 citation statements)

References 8 publications

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“…Although this is the first report to assess dyslipoproteinemia in VTE, a few limited studies of VTE and dyslipidemia based purely on lipid measurements have appeared. 20,[42][43][44] Among those studies, the association of dyslipidemia with VTE was not as strong as observed for cardiovascular diseases, and this association was controversial. Gonzalez-Ordonez et al 44 reported an association of dyslipidemia with VTE that was stronger in men than women.…”

Section: Discussionmentioning

confidence: 99%

High-Density Lipoprotein Deficiency and Dyslipoproteinemia Associated With Venous Thrombosis in Men

et al. 2005

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Background-Although dyslipoproteinemia is associated with arterial atherothrombosis, little is known about plasma lipoproteins in venous thrombosis patients. Methods and Results-We determined plasma lipoprotein subclass concentrations using nuclear magnetic resonance spectroscopy and antigenic levels of apolipoproteins AI and B in blood samples from 49 male venous thrombosis patients and matched controls aged Ͻ55 years. Venous thrombosis patients had significantly lower levels of HDL particles, large HDL particles, HDL cholesterol, and apolipoprotein AI and significantly higher levels of LDL particles and small LDL particles. The quartile-based odds ratios for decreased HDL particle and apolipoprotein AI levels in patients compared with controls were 6.5 and 6.0 (95% CI, 2.3 to 19 and 2.1 to 17), respectively. Odds ratios for apolipoprotein B/apolipoprotein AI ratio and LDL cholesterol/HDL cholesterol ratio were 6.3 and 2.7 (95% CI, 1.9 to 21 and 1.1 to 6.5), respectively. When polymorphisms in genes for hepatic lipase, endothelial lipase, and cholesteryl ester transfer protein were analyzed, patients differed significantly from controls in the allelic frequency for the TaqI B1/B2 polymorphism in cholesteryl ester transfer protein, consistent with the observed pattern of lower HDL and higher LDL. Conclusions-Venous thrombosis in men aged

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Section: Discussionmentioning

confidence: 99%

High-Density Lipoprotein Deficiency and Dyslipoproteinemia Associated With Venous Thrombosis in Men

et al. 2005

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“…Moreover, the number of patients suffering from hyperlipidemia has increased 124 and some reports have described hyperlipidemia as a risk factors for venous thromboembolism. 125,126 de Lorgeril et el indicated that PE after myocardial infarction occurred in 0/219 of patients with a Mediterranean-type diet, but in 3/204 patients with a prudent Western-type diet. 127 However, it remains to be determined how much these changes in life style influence the occurrence of PE.…”

Section: Discussionmentioning

confidence: 99%

Increasing Mortality From Pulmonary Embolism in Japan, 1951-2000.

Sakuma

Konno

Shirato

2002

Circ J

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“…2,11-13,36 -47,50 Eight were designed to evaluate risk factors for VTE. 2,11,12,38,42,44,45,47 Nine studies used either hospital discharge data 13,36,39,40,46 or data from registries. 37,41,43,50 In 2 studies, only patients with deep vein thrombosis were included.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…37,41,43,50 In 2 studies, only patients with deep vein thrombosis were included. 38,44 In only 4 of the 8 incident case-control studies, consecutive patients were enrolled. 2,38,44,45 In all but 1 study, 49 controls were matched for age.…”

Section: Study Characteristicsmentioning

confidence: 99%

Cardiovascular Risk Factors and Venous Thromboembolism

et al. 2008

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Background-The concept that venous thromboembolism (VTE) and atherosclerosis are 2 completely distinct entities has recently been challenged because patients with VTE have more asymptomatic atherosclerosis and more cardiovascular events than control subjects. We performed a meta-analysis to assess the association between cardiovascular risk factors and VTE. Methods and Results-Medline and EMBASE databases were searched to identify studies that evaluated the prevalence of major cardiovascular risk factors in VTE patients and control subjects. Studies were selected using a priori defined criteria, and each study was reviewed by 2 authors who abstracted data on study characteristics, study quality, and outcomes. Odds ratios or weighted means and 95% confidence intervals (CIs) were then calculated and pooled using a random-effects model. Statistical heterogeneity was evaluated through the use of 2 and I 2 statistics. Twenty-one case-control and cohort studies with a total of 63 552 patients met the inclusion criteria. Compared with control subjects, the risk of VTE was 2.33 for obesity (95% CI, 1.68 to 3.24), 1.51 for hypertension (95% CI, 1.23 to 1.85), 1.42 for diabetes mellitus (95% CI, 1.12 to 1.77), 1.18 for smoking (95% CI, 0.95 to 1.46), and 1.16 for hypercholesterolemia (95% CI, 0.67 to 2.02). Weighted mean high-density lipoprotein cholesterol levels were significantly lower in VTE patients, whereas no difference was observed for total and low-density lipoprotein cholesterol levels. Significant heterogeneity among studies was present in all subgroups except for the diabetes mellitus subgroup. Higher-quality studies were more homogeneous, and significant associations remained unchanged. Conclusions-Cardiovascular

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Hypercholesterolemia as a Risk Factor for Deep-Vein Thrombosis

Cited by 78 publications

References 8 publications

High-Density Lipoprotein Deficiency and Dyslipoproteinemia Associated With Venous Thrombosis in Men

High-Density Lipoprotein Deficiency and Dyslipoproteinemia Associated With Venous Thrombosis in Men

Increasing Mortality From Pulmonary Embolism in Japan, 1951-2000.

Cardiovascular Risk Factors and Venous Thromboembolism

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