Cardiovascular Risk Factors and Venous Thromboembolism

Ageno, Walter; Becattini, Cecilia; Brighton, Timothy; Selby, Rita; Kamphuisen, Pieter Willem

doi:10.1161/circulationaha.107.709204

Cited by 831 publications

(672 citation statements)

References 62 publications

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“…Smoking is a well-established risk factor for atherosclerotic disease, but its role as an independent risk factor for VTE remains controversial [30][31][32]. According to our study there is no positive relationship between smoking and RVT.…”

Section: Discussıoncontrasting

confidence: 54%

Value of Platelet Indices in Identifying Complete Resolution of Thrombus in Deep Venous Thrombosis Patients

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Altındağ

Bahadır

et al. 2014

Indian J Hematol Blood Transfus

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We aimed to evaluate whether mean platelet volume (MPV) and platelet distribution width (PDW) are helpful to identify complete thrombus resolution (CTR) after acute deep venous thrombosis (DVT). Patients who had first-time episode of acute proximal DVT were included in this retrospective study. 100 patients with DVT were divided into two groups according to absence (group 1; n = 68) or presence (group 2; n = 32) of CTR on doppler ultrasonography at month 6. There were no significant difference in admission MPV and PDW levels between group 1 and group 2. MPV (p = 0.03) and PDW (p \ 0.001) levels at month 6 were significantly higher in group 1 than in group 2. CTR showed a moderate negative correlation with PDW at month 6 (q = -0.47) and a weak negative correlation with MPV at month 6 (q = -0.26). Logistic regression analysis showed that PDW (OR, 2.2; p = 0.004) at month 6 was an independent risk factor for the presence of residual venous thrombosis in DVT patients. Receiver operating characteristics analysis revealed that a 8.4 % decrease in admission MPV at month 6 provided 62 % sensitivity and 62 % specificity (AUC: 0.64) and a 15.4 % decrease in admission PDW at month 6 provided 87 % sensitivity and 94 % specificity (AUC: 0.89) for prediction of CTR in DVT patients. Percent change in admission MPV and PDW levels at month 6 may be used to identify the patients with CTR after a first episode of acute proximal DVT.

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Section: Discussıoncontrasting

confidence: 54%

Value of Platelet Indices in Identifying Complete Resolution of Thrombus in Deep Venous Thrombosis Patients

Sevük

Altındağ

Bahadır

et al. 2014

Indian J Hematol Blood Transfus

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“…High dose OCP (≥35ug of ethynylestradiol/day) appear to increase IR in both PCOS and non-PCOS populations, potentially having adverse long term consequences (Morin-Papunen et al, 2000;Meyer et al, 2007). Additionally, obesity has a significant impact on the risk of venous thromboembolism risk (Ageno et al, 2008) which can be further aggravated by the use of OCP (Martinez and Avecilla, 2007). Data from recent research also point out to the role of a progestin type used however, further studies are warranted.…”

Section: The Use Of Oral Contraceptive Pills (Ocp) In Obese Pcos Patimentioning

confidence: 99%

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Rachoń

Teede

2010

Molecular and Cellular Endocrinology

124

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Insulin resistance (IR) is a consequence of obesity, and in women it is often inextricably linked with ovarian function leading to clinical reproductive manifestations such as early menarche onset, subfertility and polycystic ovary syndrome (PCOS). Likewise, the dramatic fall in oestrogen production after menopause may contribute to weight gain and changes in adipose tissue distribution.Overall, women who are obese, especially those with reproductive complications including PCOS, have been identified as specific high risk subgroups for further progression through to prediabetes, type 2 diabetes mellitus (T2DM) and potentially cardiovascular disease (CVD). This review focuses on the interrelationship between the ovarian function and obesity as well as its treatment strategies.

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“…Old-aged patients with DVT showed no statistically significant difference of the FMD compared to the young-middle-aged patients with DVT (6.7±5.3% vs. 6.8±5.7%, p=0.932; Fig. 2 Ageno et al 2008;Heit 2008;Isma et al 2009;Holst et al 2010). A common denominator might be represented by endothelial dysfunction.…”

Section: Resultsmentioning

confidence: 86%

Idiopathic deep venous thrombosis and arterial endothelial dysfunction in the elderly

Mazzoccoli

Fontana

Grilli

et al. 2011

AGE

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Arterial and venous thrombosis have always been regarded as different pathologies and epidemiological studies have examined the association between venous thrombosis and indicators of atherosclerosis and/or arterial thromboembolic events. We measured the flow-mediated dilation (FMD), a well-known marker of arterial endothelial dysfunction, in youngmiddle-aged and old-aged patients with and without unprovoked deep venous thrombosis (DVT). The aim of this study was to investigate whether DVT was a significant predictor for impaired FMD, considering all the patients and young-middle-aged (age<65 years) and old-aged (age≥65 years) patients separately. FMD was measured in the brachial artery on a population of 120 subjects with the same atherosclerosis risk factors, 68 male and 52 female, 70 young-middleaged subjects (mean age±SD 49.5±10.5 years) and 50 old-aged subjects (76.2±7.7 years). Patients with DVT showed a significant decrease of FMD compared to patients without DVT (6.8±5.5% vs. 10.9±3.5%, p<0.001). Moreover, old-aged patients showed a significant decrease of FMD compared to the young-middle-aged subjects (7.4±4.1% vs. 9.8± 5.3%, p=0.005). In the whole study population, DVT was strongly associated with FMD (risk factors adjusted β=−4.14, p<0.001). A significant interaction between age and the presence of DVT on predicting FMD was found (p=0.003) suggesting a AGE (2012) differential behavior of DVT as predictor of FMD. In young-middle-aged group, multivariate model confirmed that DVT was the most significant predictor of continuous FMD (β=−6.06, p<0.001). On the contrary, DVT was no more a predictor of FMD in the old age group (β=−0.73, p=0.556). Furthermore, old-aged patients without DVT showed a statistically significant decrease of FMD compared to the youngmiddle-aged subjects without DVT (8.2±2.1% vs. 12.6±2.7%, p<0.001) and old-aged patients with DVT showed a not statistically significant decrease of the FMD compared to the young-middle-aged patients with DVT (6.7±5.3% vs. 6.8±5.7%, p= 0.932). In conclusion, young-middle-aged patients with spontaneous DVT show an impaired FMD, whereas this impairment in old-aged subjects is evident independently from the presence or absence of DVT. Aging per se may be associated with physiologic abnormalities in the systemic arteries and with endothelial dysfunction.34:751-760 DOI 10.1007/s11357-011-9265-

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Cardiovascular Risk Factors and Venous Thromboembolism

Cited by 831 publications

References 62 publications

Value of Platelet Indices in Identifying Complete Resolution of Thrombus in Deep Venous Thrombosis Patients

Value of Platelet Indices in Identifying Complete Resolution of Thrombus in Deep Venous Thrombosis Patients

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Idiopathic deep venous thrombosis and arterial endothelial dysfunction in the elderly

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