Hyperbaric oxygen therapy improves health‐related quality of life in patients with diabetes and chronic foot ulcer

Löndahl, Magnus; Landin‐Olsson, Mona; Katzman, Per

doi:10.1111/j.1464-5491.2010.03185.x

Cited by 51 publications

(32 citation statements)

References 26 publications

(38 reference statements)

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“…A prospective study of the role of hyperbaric oxygen treatment found that patients with healed DFUs had higher MCS scores, social function, and role limitation due to physical and emotional health than patients who did not heal (38). A more recent study by the Eurodiale group demonstrated that healing of DFUs was associated with improved HRQOL; however, nonhealing was not associated with a deterioration in HRQOL (39).…”

Section: The Impact Of Dfd On Hrqolmentioning

confidence: 99%

Assessing Health-Related Quality of Life in Patients With Diabetic Foot Disease: Why Is It Important and How Can We Improve? The 2017 Roger E. Pecoraro Award Lecture

Wukich

Raspovic

2018

Diabetes Care

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Patient-reported outcomes (PROs) have become an important subject in the area of diabetes-related foot complications. Self-reported health-related quality of life (HRQOL) surveys can provide a generic measure of overall health (global) and can be disease specific (i.e., diabetes) or even region specific (i.e., lower-extremity function). Analysis of PRO measures utilizing validated instruments allows health care providers to determine whether medical and surgical treatments are providing patients with the highest level of outcome possible and are actually improving HRQOL. The 36-item Short Form (SF-36), EuroQol five-dimension questionnaire (EQ-5D-5L), and Foot and Ankle Ability Measure (FAAM) are examples of commonly used HRQOL surveys. Low HRQOL has been associated with higher rates of hospital admission and mortality in patients with diabetes. Previous studies have demonstrated that patients with diabetes-related foot disease have low self-reported physical quality of life but do not typically report low mental quality of life. The impact of mental quality of life may be underestimated in these patients using the SF-36. In this article, we will discuss several widely used outcome instruments used to measure patient HRQOL and the impact of diabetic foot disease on HRQOL. As health care providers, we must continue to adjust and modify our treatments to achieve the best patient outcomes and associated high quality of life. Assessing PROs will become increasingly important as health care systems transition from a volume-based reimbursement model to a value-based model.

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Section: The Impact Of Dfd On Hrqolmentioning

confidence: 99%

Assessing Health-Related Quality of Life in Patients With Diabetic Foot Disease: Why Is It Important and How Can We Improve? The 2017 Roger E. Pecoraro Award Lecture

Wukich

Raspovic

2018

Diabetes Care

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“…amputation rates (Faglia et al 1996;Thackham et al 2008;Bishop and Mudge 2012), and improving quality of life for these individuals (Londahl et al 2011).…”

mentioning

confidence: 99%

Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice

Verma

Chopra

Giardina

et al. 2015

Cell Stress and Chaperones

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The disease burden from diabetic kidney disease is large and growing. Effective therapies are lacking, despite an urgent need. Hyperbaric oxygen therapy (HBOT) activates Nrf2 and cellular antioxidant defenses; therefore, it may be generally useful for treating conditions that feature chronic oxidative tissue damage. Herein, we determined how periodic exposure to oxygen at elevated pressure affected type 2 diabetes mellitus-related changes in the kidneys of db/db mice. Two groups of db/db mice, designated 2.4 ATA and 1.5 ATA, were treated four times per week with 100 % oxygen at either 1.5 or 2.4 ATA (atmospheres absolute) followed by tests to assess kidney damage and function. The sham group of db/db mice and the Hets group of db/+ mice were handled but did not receive HBOT. Several markers of kidney damage were reduced significantly in the HBOT groups including urinary biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (CyC) along with significantly lower levels of caspase-3 activity in kidney tissue extracts. Other stress biomarkers also showed trends to improvement in the HBOT groups, including urinary albumin levels. Expressions of the stress response genes NRF2, HMOX1, MT1, and HSPA1A were reduced in the HBOT groups at the end of the experiment, consistent with reduced kidney damage in treated mice. Urinary albumin/creatinine ratio (ACR), a measure of albuminuria, was significantly reduced in the db/db mice receiving HBOT. All of the db/db mouse groups had qualitatively similar changes in renal histopathology. Glycogenated nuclei, not previously reported in db/db mice, were observed in these three experimental groups but not in the control group of nondiabetic mice. Overall, our findings are consistent with therapeutic HBOT alleviating stress and damage in the diabetic kidney through cytoprotective responses. These findings support an emerging paradigm in which tissue oxygenation and cellular defenses effectively limit damage from chronic oxidative stress more effectively than chemical antioxidants.

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“…Nekoliko studija ukazuje da HBOT ispoljava povoljne efekte i na glikoregulaciju. [12][13][14][15][16].…”

Section: Uvodunclassified

Efekti primjene hiperbarične oksigenoterapije na koncentraciju glukoze, triglicerida i holesterola u serumu oboljelih od tipa 2 dijabetes melitusa

Sladoje

Ristić

Maric

et al. 2012

Biomedicinska istraž.

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Kratak sadržajUvod. Dosadašnja istraživanja ukazuju da hiperbarična oksigenoterapija (HBOT) može da ispoljava povoljne efekte na parametre glikoregulacije i inflamacije. Cilj ovog istraživanja je da se utvrdi da li primjena hiperbarične oksigenoterapije utiče na koncentraciju glukoze, triglicerida i holesterola u serumu oboljelih od tipa 2 dijabetes melitusa (DM tip 2).Metode. U studiju je uključen 41 bolesnik sa DM tip 2. Svi su podvrgnuti HBOT 100% kiseonikom pod povišenim pritiskom u trajanju od sat vremena, po pet dana nedjeljno, tokom dvije nedjelje. Pacijentima su određivane koncentrcije glukoze, holesterola (ukupnog, HDL i LDL) i triglicerida u serumu, natašte, prije prvog tretmana HBOT i nakon desetog tretmana HBOT.Rezultati. Poslije dvije nedjelje primjene HBOT kod bolesnika sa DM tip 2 zabilježeno je smanjenje glikemije (9,7 vs. 8,0 mmol/l; p = 0,022) i koncentracije LDL holesterola (4,99 vs. 4,4 mmol/l; p = 0,013) kao i ukupnog holesterola (6,62 vs. 6,06 mmol/l; p =0,015) u serumu. HBOT nije dovela do značajnih promjena koncentracije HDL holesterola (1,22 vs. 1,38 mmol/l; p = 0,66) i triglicerida (1,76 vs. 1,58 mmol/l, p = 0,089) u serumu.Zaključak. Primjena HBOT smanjuje glikemiju i koncentraciju proaterogenih lipida u serumu što može da ima višestruko korisne dejstvo kod oboljelih od DM tip 2.Ključne riječi: hiperbarična oksigenoterapija, tip 2 diabetes mellitus-a, glikemija, lipidemija UvodHiperbarična oksigenoterapija (HBOT) podrazumjeva primjenu 100% kiseonika pod pritiskom koji je veći od onog u atmosferi.Koristi se kao terapija kod različitih stanja: hronične rane koje teško zarastaju, infekcije (posebno one uzrokovane anaerobnim

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Hyperbaric oxygen therapy improves health‐related quality of life in patients with diabetes and chronic foot ulcer

Abstract: Hyperbaric oxygen therapy improves long-term health related quality of life in patients with chronic diabetic foot ulcers, possibly attributable to better ulcer healing.

Cited by 51 publications

References 26 publications

Assessing Health-Related Quality of Life in Patients With Diabetic Foot Disease: Why Is It Important and How Can We Improve? The 2017 Roger E. Pecoraro Award Lecture

Assessing Health-Related Quality of Life in Patients With Diabetic Foot Disease: Why Is It Important and How Can We Improve? The 2017 Roger E. Pecoraro Award Lecture

Hyperbaric oxygen therapy (HBOT) suppresses biomarkers of cell stress and kidney injury in diabetic mice

Efekti primjene hiperbarične oksigenoterapije na koncentraciju glukoze, triglicerida i holesterola u serumu oboljelih od tipa 2 dijabetes melitusa

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