The paper dwells on issues related to quality of drinking water from centralized water supply systems; spotting out priority health risk factors; and assessing efficiency of control and surveillance activities performed by Rospotrebnadzor in the sphere of drinking water supply to the RF population. It was detected that in most RF regions control activities performed within social-hygienic monitoring mainly covered contents of substances belonging to the 3 rd and 4 th hazard categories in drinking water while contents of the 1 st hazard category substances were controlled only in several RF regions. The highest shares of samples exceeding hygienic standards as per contents of the 1 st hazard category substances were detected for such dangerous chemicals as chloroform, bromodichloromethane, trichloroethylene, 1,2-dichloroethane, tetrachloromethane, tetrachloroethylene, and arsenic. Chlorine and chlorinated organic compounds, ammonium and chemicals that contain ammonium ion, iron, manganese, arsenic, nickel, and copper compounds, as well as microbiological contamination of water remain priority risk factors with the greatest contribution made into additional incidence associated with poor quality of drinking water taken from communal water supply systems. On average in the RF, in 2018 efficiency of Rospotrebnadzor activities estimated as per prevented GRP (gross regional product) losses caused by drinking water quality amounted to 70.1 ± 10.1 ruble per 1 ruble of costs. The highest values of the criterion were registered for the 3 rd cluster (67.7 ruble per 1 ruble of costs); the lowest ones, for the 1 st cluster (47.4 rubles per 1 ruble of costs). Taking into account region peculiarities and different types of territories, it is necessary to develop specific regional programs and action plans aimed at preserving already obtained levels of population provision with qualitative drinking water, improving control and surveillance activities with wide implementation of risk-oriented approach, achieving targets fixed in national project and federal programs.