Hydroxyapatite reinforced polyethylene — a mechanically compatible implant material for bone replacement

Bonfield, W.; Grynpas, Marc D.; Tully, Andy; Bowman, Jeremy; Abram, J. E.

doi:10.1016/0142-9612(81)90050-8

Cited by 519 publications

(272 citation statements)

References 7 publications

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“…Com o mesmo objetivo surgiram os compósitos cerâmicas/polímeros, onde as propriedades mecânicas do polímero são otimizadas utilizando-se a cerâmica como reforço, além da propriedade de bioatividade das mesmas. [30] A presença de partículas do material no interior de células multinucleadas sugere que ele seja degradado ao longo dos períodos experimentais, como observado em outro estudo onde houve reabsorção parcial e substituição por tecido conjuntivo em tecido subcutâneo de ratos. [31] A tendência atual é procurar desenvolver compósitos utilizando polímeros biodegradáveis.…”

Section: Discussionunclassified

Resposta do tecido subcutâneo de camundongos à implantação de um novo biovidro à base de óxido de nióbio

Lima¹,

Silva²,

Barros³

et al. 2011

Matéria (Rio J.)

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RESUMOO objetivo deste estudo foi avaliar a resposta biológica do tecido subcutâneo de camundongos à implantação de um novo biovidro à base de óxido de nióbio e óxido fosforoso. A morfologia do material foi analisada por microscopia eletrônica de varredura com espectroscopia de raios X por dispersão de energia (MEV/EDX) e a resposta tecidual foi avaliada após implantação de 30mg do biovidro no tecido subcutâneo da região dorsal de camundongos Balb/c (n=15), segundo ISO 10993-6. Após o período de 1, 3 e 9 semanas, os animais foram sacrificados e as necrópsias fixadas em formol tamponado pH 7,2 e submetidas ao processamento clássico para inclusão em parafina. Contudo, nenhum processo convencional de desmineralização de ossos e biomateriais cerâmicos foi capaz de desmineralizar o material. Alternativamente, o material obtido foi reprocessado e incluído em resina para corte em micrótomo de impacto. O estudo histopatológico considerou para análise: reação inflamatória (intensidade de células polimorfonucleares, mononucleares e células gigantes multinucledas das do tipo corpo estranho) e processo de reparo (tecido de granulação e fibrose). A análise do biomaterial no MEV/EDS demonstrou partículas irregulares com ampla variação dimensional e presença de nióbio, fósforo, cálcio, carbono e oxigênio. A análise histológica mostrou moderado infiltrado inflamatório composto de células mononucleares na semana 1, a qual desapareceu nos períodos subsequentes. Após 3 e 9 semanas, vasos sanguíneos foram observados com presença discreta de células gigantes multinucleadas tipo corpo estranho contendo partículas de biovidro de nióbio. Mesmo após 9 semanas, não se observou presença de cápsula fibrosa ao redor do material. Em nenhum momento, verificaram-se focos de necrose nem sinais de degradação das partículas. Baseado nestes resultados preliminares foi possível concluir que o material testado é biocompatível e não-bioabsorvível. A comparação deste biovidro contendo nióbio, especialmente implantado intra-ósseo, permitirá avaliar seu real potencial uso como enxerto ósseo. Palavras chaves: biomaterial, biovidro, óxido de nióbio, biocompatibilidadeBiocompatibility in vivo study of a new bioglass made up niobium oxide ABSTRACTThe aim of this study was to evaluate the biological response to the implantation of a new biocompatible glass based on niobium oxide and phosphorus oxide. Scanning electron microscopy with energy dispersive spectroscopy evaluated the morphology of the material (SEM/EDS) and the tissue response was evaluated by implantation of 30mg of biocompatible glass on subcutaneous tissue of Balb/c mice (n=15) as ISO 10993-6. After the period of 1, 3 and 9 weeks, the animals were killed and the necropsies were fixed in buffered formalin pH 7.2 and processed for inclusion in paraffin after demineralization step in Allkymia solution; however, no

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Section: Discussionunclassified

Resposta do tecido subcutâneo de camundongos à implantação de um novo biovidro à base de óxido de nióbio

Lima¹,

Silva²,

Barros³

et al. 2011

Matéria (Rio J.)

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“…This problem has been recognized specifically when used as metal implants in long bones as total hip replacement implants but in reconstructions of segmental defects of mandible, lack of isoelasticity may play a role too. Metal implants may also induce cytotoxic reactions arising from the release of metal ions, corrosion products and nanoparticles [3][4][5]. Potential cytotoxicity arising from heavy metal ion liberation and harmful corrosion products and nanoparticles are suggested to be harmful for the immunological system of human body, which in the case of released Ti 4? ions are causing soft tissue atrophy and potentially exposure of the implants [6].…”

Section: Introductionmentioning

confidence: 99%

Bioactive glass-containing cranial implants: an overview

Vallittu

2017

J Mater Sci

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Although metals have successfully been used as implants for decades, devices made out of metals do not meet all clinical requirements. For example, metal objects may interfere with some medical imaging systems (computer tomography, magnetic resonance imaging), while their stiffness also differs from natural bone and may cause stress-shielding and over-loading of bone. There has been a lot of development in the field of composite biomaterial research, which has focused to a large extent on biodegradable composites. This overview article reviews the rationale of using glass fiber-reinforced composite-bioactive glass (FRC-BG) in cranial implants. For this overview, published scientific articles with the search term ''bioactive glass cranial implant'' were collected for having basis to introduce a novel design of composite implant, which contains bioactive glass. Additional scientific information was based on articles in the fields of chemistry, engineering sciences and dentistry. Published articles of the material properties, biocompatibility and possibility to add bioactive glass to the FRC-BG implants alongside with the clinical experience as far suggest that there is a clinical need for bioactive nonmetallic implants. In the FRC-BG implants, biostable glass fibers are responsible for the load-bearing capacity of the implant, while the dissolution of the bioactive glass particles supports osteogenesis and vascularization and provides antimicrobial properties for the implant. Material combination of FRC-BG has been used clinically in cranioplasty and cranio-maxillo-facial implants, and they have been investigated also as oral and orthopedic implants. Material combination of FRC-BG has successfully been introduced to be a potential implant material in cranial surgery.

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“…This is an advantage over metal implants, for which further surgery to remove the implant is necessary (Paivarinta et al 1993). The combination of polymers with calcium phosphate has been widely studied since this concept offers improved mechanical properties, while maintaining the favourable biocompatibility and osteoconductivity of calcium phosphates (Bonfield et al 1981;Suchanek & Yoshimura 1998). These composites often consist of a degradable polyester matrix to which calcium phosphate fibres or particles are added (Agrawal & Athanasiou 1997;Suchanek & Yoshimura 1998;Imai et al 1999;Heidemann et al 2001;Ignatius et al 2001;Ara et al 2002;Kikuchi et al 2002;Niemela et al 2004a;Niemela 2005).…”

Section: Introductionmentioning

confidence: 99%

The degradation properties of co-continuous calcium phosphate polyester composites: insights with synchrotron micro-computer tomography

Ehrenfried

Farrar

Cameron

2010

J. R. Soc. Interface.

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This study investigates the in vitro degradation properties of composites consisting of a porous tricalcium phosphate (TCP) foam filled with degradable poly(DL-lactic acid) (PDLLA) via either in situ polymerization or infiltration. The motivation was to develop a material for bone repair that would be initially mechanically strong and would develop porosity during degradation of one of the components. A thorough analysis of the physical in vitro degradation properties has been conducted and reported by the same authors elsewhere. Synchrotron microcomputer tomography analysis (conducted at ID19, ESRF, Grenoble, France) allowed detailed insights to be gained into the process of the composites' degradation, which was discovered to be strongly influenced by the manufacturing method. The polymer phase of in situ-polymerized TCP-PDLLA degraded as a bulk sample, with faster degradation in the centre of the sample as a whole. In contrast, the polymer phase of infiltrated TCP-PDLLA degraded as individual polymer spheres with faster degradation in the centre of each sphere.

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Hydroxyapatite reinforced polyethylene — a mechanically compatible implant material for bone replacement

Cited by 519 publications

References 7 publications

Resposta do tecido subcutâneo de camundongos à implantação de um novo biovidro à base de óxido de nióbio

Resposta do tecido subcutâneo de camundongos à implantação de um novo biovidro à base de óxido de nióbio

Bioactive glass-containing cranial implants: an overview

The degradation properties of co-continuous calcium phosphate polyester composites: insights with synchrotron micro-computer tomography

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