The degradation properties of co-continuous calcium phosphate polyester composites: insights with synchrotron micro-computer tomography

Ehrenfried, Lisa M.; Farrar, David; Cameron, Ruth E.

doi:10.1098/rsif.2010.0014.focus

Cited by 7 publications

(5 citation statements)

References 47 publications

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“…The in vitro degradation rate of CaP/polymer composites can vary substantially depending on the polymers and the ceramic components, as well as the manufacturing methods 30–32. The CaP/PUR composites in this study degraded slowly in vitro , with the degradation rates in PBS ranging from 0.8 to 2.0 wt %/week.…”

Section: Discussionmentioning

confidence: 84%

Synthesis, characterization of calcium phosphates/polyurethane composites for weight‐bearing implants

et al. 2011

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Calcium phosphate (CaP)/polymer composites have been studied as an alternative graft material for the treatment of bone defects. In this study, lysine-triisocyanate-based polyurethane (PUR) composites were synthesized from both hydroxyapatite (HA) and β-tricalcium phosphate (TCP) to reduce the brittleness of CaP and increase the bioactivity of the polymer. The mechanical properties and in vitro cellular response were investigated for both HA/PUR and TCP/PUR composites. The composites were implanted in femoral defects in rats, and in vivo bioactivity was evaluated by X-rays, micro-computed tomography (μCT), and histological sections. In biomechanical testing, PUR improved the mechanical properties of the CaP, thus rendering it potentially suitable for weight-bearing applications. In vitro cell culture studies showed that CaP/PUR composites are biocompatible, with β-TCP enhancing the cell viability and proliferation relative to HA. CaP/PUR composites also supported the differentiation of osteoblastic cells on the materials. When implanted in rat femoral defects, the CaP/PUR composites were biocompatible and osteoconductive with no adverse inflammatory response, as evidenced by X-rays, μCT images, and histological sections. Additionally, a histological examination showed evidence of cellular infiltration and appositional remodeling. These results suggest that CaP/PUR composites could be potentially useful biomaterials for weight-bearing orthopaedic implants.

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Section: Discussionmentioning

confidence: 84%

Synthesis, characterization of calcium phosphates/polyurethane composites for weight‐bearing implants

et al. 2011

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“…The complete degradation of pure-phase β-TCP in humans and animal models occurs within a 6–12-month period [ 47 ], which is far quicker than PDLLA (12–30 months) [ 7 , 48 , 49 ] and β-TCP/PDLLA (9–19 months) [ 50 , 51 ]. The rapid resorption will provide more space for tissue ingrowth and release large amounts of Ca 2+ and P 5+ ions into the milieu, which are essential for osteoblast maturation and bone formation [ 52 ].…”

Section: Discussionmentioning

confidence: 99%

Feasibility of Application of the Newly Developed Nano-Biomaterial, β-TCP/PDLLA, in Maxillofacial Reconstructive Surgery: A Pilot Rat Study

et al. 2021

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This study was performed to examine the applicability of the newly developed nano-biocomposite, β-tricalcium phosphate (β-TCP)/u-HA/poly-d/l-lactide (PDLLA), to bone defects in the oral and maxillofacial area. This novel nano-biocomposite showed several advantages, including biocompatibility, biodegradability, and osteoconductivity. In addition, its optimal plasticity also allowed its utilization in irregular critical bone defect reconstructive surgery. Here, three different nano-biomaterials, i.e., β-TCP/PDLLA, β-TCP, and PDLLA, were implanted into critical bone defects in the right lateral mandible of 10-week-old Sprague–Dawley (SD) rats as bone graft substitutes. Micro-computed tomography (Micro-CT) and immunohistochemical staining for the osteogenesis biomarkers, Runx2, osteocalcin, and the leptin receptor, were performed to investigate and compare bone regeneration between the groups. Although the micro-CT results showed the highest bone mineral density (BMD) and bone volume to total volume (BV/TV) with β-TCP, immunohistochemical analysis indicated better osteogenesis-promoting ability of β-TCP/PDLLA, especially at an early stage of the bone healing process. These results confirmed that the novel nano-biocomposite, β-TCP/PDLLA, which has excellent biocompatibility, bioresorbability and bioactive/osteoconductivity, has the potential to become a next-generation biomaterial for use as a bone graft substitute in maxillofacial reconstructive surgery.

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“…The most commonly used manufacturing technology for PDLLA/ β ‐TCP is the in situ copolymerization method. [ 116–118 ] Studies have shown that increasing the amount of β ‐TCP does increase the mechanical properties of the composite scaffolds. In the presence of catalyst, the mechanical properties of the PDLLA/ β ‐TCP composite scaffolds with 30% β ‐TCP added were the best.…”

Section: Bionic “Hard” Scaffolds Of Bioceramics Based On α‐Hydroxy Ca...mentioning

confidence: 99%

“…Compared with the melt penetration method, the bionic bone scaffolds prepared by in situ copolymerization method show better comprehensive performance. [ 118 ] The slightly lower molecular weight of the scaffolds make water absorption and degradation faster. The less force applied to the β ‐TCP surface results in almost no cracks on the surface of the scaffolds and only slight swelling was observed at the ceramic edges.…”

Section: Bionic “Hard” Scaffolds Of Bioceramics Based On α‐Hydroxy Ca...mentioning

confidence: 99%

Chirality‐Induced Bionic Scaffolds in Bone Defects Repair—A Review

Sun

Liu

Wei

et al. 2022

Macromolecular Bioscience

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Due to lack of amino sugar with aging, people will suffer from various epidemic bone diseases called “undead cancer” by the World Health Organization. The key problem in bone tissue engineering that is not completely resolved is the repair of critical large‐scale bone and cartilage defects. The chirality of the extracellular matrix plays a decisive role in the physiological activity of bone cells and the occurrence of bone tissue, but the mechanism of chirality in regulating cell adhesion and growth is still in the early stage of exploration. The application progress of chirality‐induced bionic scaffolds is reviewed here in bone defects repair based on “soft” and “hard” scaffolds. The aim is to summarize the effects of different chiral structures (l‐shaped and d‐shaped) in the process of inducing bionic scaffolds in bone defects repair. In addition, many technologies and methods as well as issues worthy of special consideration for preparing chirality‐induced bionic scaffolds are also introduced. It is expected that this work can provide inspiring ideas for designing new chirality‐induced bionic scaffolds and promote the development of chirality in bone tissue engineering.

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The degradation properties of co-continuous calcium phosphate polyester composites: insights with synchrotron micro-computer tomography

Cited by 7 publications

References 47 publications

Synthesis, characterization of calcium phosphates/polyurethane composites for weight‐bearing implants

Synthesis, characterization of calcium phosphates/polyurethane composites for weight‐bearing implants

Feasibility of Application of the Newly Developed Nano-Biomaterial, β-TCP/PDLLA, in Maxillofacial Reconstructive Surgery: A Pilot Rat Study

Chirality‐Induced Bionic Scaffolds in Bone Defects Repair—A Review

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