Hydroxyapatite catalyzed aldol condensation: Synthesis, spectral linearity, antimicrobial and insect antifeedant activities of some 2,5-dimethyl-3-furyl chalcones

Synthesis, Spectral Correlations and Antimicrobial Activities of some 2-Hydroxyphenyl-Styrylketone

“…In the present study the Hammett spectral linearity of these synthesised chalcones has been studied by evaluating the substituent effects [1,16,40,41] on the group frequencies. The assigned spectroscopic data of all chalcones such as absorption maximum λ max (nm) of carbonyl groups, infrared carbonyl stretches of νCOs-cis and s-trans, the deformation modes of vinyl part CH out of plane, in-plane, CH=CH and >C=C< out of planes (cm -1 ), NMR chemical shifts δ(ppm) of H α , H β , C α , C β , CO are assigned and these data are correlated with various substituent constants.…”

“…The compounds with the backbone [6] of chalcone have been reported to exhibit a wide variety of pharmacological effects including, antimalarial [7][8][9], antiviral [10][11][12], antibacterial [13][14][15], antiplosmodial [16], antifungal [17][18][19], anticancer [20][21][22], anti-leishmaninal [23], anti-inflammatory [24], antipyretic [25], analgesic [26], antiulcerative [27], antihyperglycemic [28], antioxidant [29], antiinvasive [30], antiplatelet [31] and insect antifeedent [32], antihyperglycemic [33], antifeedent [34] immunomodulatory [35], inhibition of chemical mediators release [36], inhibition of leukotriene B 4 [37], inhibition of tyrosinase [38], and inhibition of aldose reductase [39] activities. At present, scientists have paid more interest to correlate the group frequencies of spectral data with Hammett substituent constants to explain the substituent effects of organic compounds, Subramanian et al [40] have studied the effect of substituents through spectral linearity and antimicrobial activities of some furyl chalcones. In their studies, they observed satisfactory and good correlations for each spectral data with Hammett substituent constants, F and R parameters.…”

Assessment of Substituent Effects and Antimicrobial Activities of some 2ʹ,5ʹ-Dimethyl Phenyl Chalcones

“…These absorption maxima (λmax, nm) of these chalcones International Letters of Chemistry, Physics and Astronomy Vol. 24were correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis [1, 4,[22][23][31][32][33][34][35][36][37][38]. Hammett correlation involving the group frequencies and absorption maxima, the form of the Hammett equation employed is λmax = ρσ + λ 0…”

“…From the Table 3, the results of statistical analysis [1, 4,[22][23][31][32][33][34][35][36][37][38] of these UV absorption maxima (λmax, nm) data with Hammett substituent constants, except that with 4-NO 2 substituent have shown satisfactory correlations with Hammett substituent constant σ (r = 0.905) and except those with 4-Br and 4-NO 2 substituents have shown satisfactory correlations with Hammett substituent constant σ + (r = 0.906). The remaining Hammett substituent constants σ I, σ R and F and R parameters have shown poor correlations (r < 0.900).…”

“…al. [22,23] has studied the synthesis and spectral correlations of some heterocyclic chalcones and they observed satisfactory correlations.…”