Synthesis, Spectral Correlations and Antimicrobial Activities of some 2-Hydroxyphenyl-Styrylketone

Abstract

Some 2'-hydroxyphenylchalcones have been synthesized under microwave irradiation by ClaisenSchmidt condensation between substituted 2-hydroxyacetophenone and substituted benzaldehydes using catalytic amount of SiO 2 -H 3 PO 4 . These chalcones were established by their physical constants and spectroscopic data published earlier. The UV, IR, 1 H NMR and 13 C NMR spectral data of these chalcone have correlated with Hammett substituent constants, F and R parameters. All the compounds have been subjected to screened for antimicrobial activity.

Spectral QSAR and QPR Study of some (<i>E</i>)-4-(((2-Hydroxy-6-(Substituted Phenyl)-1,6 Dihydropyrimidin-4-yl)Methyl)Diazenyl)Benzoic Acid Derivatives

“…The results of statistical analysis [11][12][13][14][15][16][18][19][20][21] are shown in Table 2. From the table 2, the correlation of νCO stretches of all compounds gave satisfactory correlation for Hammett σ, σ + , and σ I constants.…”

“…The CO, CH 2 , and CN carbon chemical shifts (δ, ppm) of pyrimidine derivatives have been assigned and correlated with Hammett substituent constants using single and multi-linear regression analysis [11][12][13][14][15][16][18][19][20][21].…”

“…They possess valuable biological activities such as cardiovascular [3], anti-HIV [4], anti-tumour [5], antiinflammatory [6], anti-tubercular [7], diuretic [8], antimicrobial [9] anti-cancer [9] and antimalarial [10]. Spectroscopic data was applied for predicting the ground state configuration and QSAR and QPR study of chalcones [11], oxazines [12], pyrazoline [13], imines [14], acyl halides, and it esters [15]. Using infrared functional group frequencies such as carbonyl absorpitons, chemists studied the s-cis and s-trans conformers of chalcones [16], cis-and gauche-form of acyl esters [15].…”

Assessment of Substituent Effects and Antimicrobial Activities of some 2ʹ,5ʹ-Dimethyl Phenyl Chalcones

“…These absorption maxima (λmax, nm) of these chalcones International Letters of Chemistry, Physics and Astronomy Vol. 24were correlated with Hammett substituent constants and F and R parameters using single and multi-linear regression analysis [1, 4,[22][23][31][32][33][34][35][36][37][38]. Hammett correlation involving the group frequencies and absorption maxima, the form of the Hammett equation employed is λmax = ρσ + λ 0…”

IR &amp; NMR Spectral Studies of some 7-Substituted 9H-Fluorenacyl Bromides: Assessment of Substituent Effects

“…Spectroscopic data are useful for prediction of ground state equilibration of organic molecules such as aryl ketones, alkenes, unsaturated carbonyl compounds, acyl chlorides and their esters [1][2][3][4][5]. The quantitative structure activity relationship and quantitative structure property relationships were used for finding the structure of molecule, quantitative and qualitative analysis [6,7].…”