Hydrothermally treated titanium surfaces for enhanced osteogenic differentiation of adipose derived stem cells

Manivasagam, Vignesh K.; Popat, Ketul C.

doi:10.1016/j.msec.2021.112315

Cited by 16 publications

(23 citation statements)

References 68 publications

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“…nTi surface had developed micro‐nano topography after the thermochemical treatment (Figure 1). 2,35 Further, the SEM images nTi‐S and nTi‐PEG did not show any significant difference in the surface topography when compared to nTi surfaces.…”

Section: Resultsmentioning

confidence: 88%

“…The thermochemical treatment on Ti substrates with sulfuric acid under control conditions can lead to the following chemical reactions:

{TiO}_{2} goodbreak+ 2 H_{2} {SO}_{4} \to Ti {({SO}_{4})}_{2} goodbreak+ 2 H_{2} normalO

Ti goodbreak+ 2 H_{2} {SO}_{4} \to Ti {({SO}_{4})}_{2} goodbreak+ 2 H_{2}

Ti goodbreak+ 2 H_{2} normalO \to {TiO}_{2} goodbreak+ 2 H_{2}

Ti goodbreak+ H_{2} \to {TiH}_{2}

These reactions developed a micron scale topography on nTi due to faster etching at the grain boundaries. This is because grain boundaries have higher surface energy as there is disordered atomic arrangement 2,35,62 . Further, nanoscale pits were also visible on the grain surface due to comparatively slower etching.…”

Section: Discussionmentioning

confidence: 99%

“…This is because grain boundaries have higher surface energy as there is disordered atomic arrangement. 2,35,62 Further, nanoscale pits were also visible on the grain surface due to comparatively slower etching. Thus, the images indicate that the thermochemical treatment led to a micro-nano topography on Ti surface.…”

Section: Discussionmentioning

confidence: 99%

“…[32][33][34] In this study, a simple thermochemical treatment was used to develop micro-nano surface topography on titanium surface. 2,31,35 Titanium based materials are commonly used for cardiac implants due to their favorable biocompatibility and mechanical properties. [36][37][38] The surfaces were further modified using heptadecafluoro-1,1,2,2-tetrahydrodecyl trichlorosilane and poly-ethyleneglycol 2-[methoxy(polyethyleneoxy)propyl] trimethoxysilane to alter the chemistry and wettability of the surface.…”

Section: Introductionmentioning

confidence: 99%

“…In this study, a simple thermochemical treatment was used to develop micro‐nano surface topography on titanium surface 2,31,35 . Titanium based materials are commonly used for cardiac implants due to their favorable biocompatibility and mechanical properties 36–38 .…”

Section: Introductionmentioning

confidence: 99%

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Enhanced antibacterial properties on superhydrophobic micro‐nano structured titanium surface

Manivasagam

Perumal

Arora

et al. 2022

J Biomedical Materials Res

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Micro/nano scale surface modifications of titanium based orthopedic and cardiovascular implants has shown to augment biocompatibility. However, bacterial infection remains a serious concern for implant failure, aggravated by increasing antibiotic resistance and over usage of antibiotics. Bacteria cell adhesion on implant surface leads to colonization and biofilm formation resulting in morbidity and mortality. Hence, there is a need to develop new implant surfaces with high antibacterial properties. Recent developments have shown that superhydrophobic surfaces prevent protein and bacteria cell adhesion. In this study, a thermochemical treatment was used modify the surface properties for high efficacy antibacterial activity on titanium surface. The modification led to a micro‐nano surface topography and upon modification with polyethylene glycol (PEG) and silane the surfaces were superhydrophilic and superhydrophobic, respectively. The modified surfaces were characterized for morphology, wettability, chemistry, corrosion resistance and surface charge. The antibacterial capability was characterized with Staphylococcus aureus and Escherichia coli by evaluating the bacteria cell inhibition, adhesion kinetics, and biofilm formation. The results indicated that the superhydrophobic micro‐nano structured titanium surface reduced bacteria cell adhesion significantly (>90%) and prevented biofilm formation compared to the unmodified titanium surface after 24 h of incubation.

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Section: Resultsmentioning

confidence: 88%

“…The thermochemical treatment on Ti substrates with sulfuric acid under control conditions can lead to the following chemical reactions: