Surface-modified WE43 magnesium alloys for reduced degradation and superior biocompatibility

Manivasagam, Vignesh K.; Sankar, M.; Garcia, Caterina Bartomeu; Vishnu, Jithin; Chatterjee, Kaushik; Suwas, Satyam; Manivasagam, Geetha; Webster, Thomas J.

doi:10.1007/s44164-022-00016-x

Cited by 6 publications

(1 citation statement)

References 57 publications

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“…Manivasagam et al studied the surface of a WE43 alloy deformed by SMAT. 151) They found an increase in hardness, roughness, surface oxide layer and hydrophilicity, as well as a 90% increase in corrosion resistance. Human fetal osteoblast (hFOB) cells showed higher biocompatibility on SMATtreated substrates, with the bone matrix depositing significantly more Ca 2+ .…”

Section: Magnesium Alloysmentioning

confidence: 96%

Surface Severe Plastic Deformation for Improved Mechanical/Corrosion Properties and Further Applications in the Bio-Medical and Hydrogen Sectors

2023

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Various techniques enabling surface severe plastic deformation (SSPD) have been developed or optimised over the past years. This manuscript presents a broad overview of recent developments in the field of SSPD and its application that take advantages of having a deformed gradient surface with both (i) higher strength and (ii) an improved "reactivity". First, the principle and technological advantages/ disadvantages of several SSPD technologies, involving either guided or non-directional mechanical impacts, are recalled. Then, after a short recall on the nature of the structure the modified surface formed under SSPD, the effects of the processing parameters and temperature of deformation on the surface roughness and subsurface microstructure modifications are illustrated with a particular emphasis on the surface mechanical attrition treatment (SMAT) and ultrasonic shot peening (USP) techniques deriving from the traditional pre-strain shot peening. The effect of these surface and sub-surface modifications on the mechanical properties, and in particular the fatigue response, are recalled with a special emphasis on the surface integrity and potential over shot peening. Then, the manuscript concentrates on the effect of the surface enhanced diffusion of chemical species induced by the presence of structural defects to modify the corrosion behaviour and enhance the potential assisted SSPD + thermo-chemically "duplex" treatments. In these cases, in addition to induce grain refinement and dislocations, the importance of controlling some potential surface contamination is stressed. Finally, the manuscript terminates by illustrating some new research studies on potential applications for the challenges in the hydrogen sector for its solid-state storage and the protection of mechanical infrastructures as well as for bio-medical applications with biocompatible Ti-based alloys and biodegradable Mg-based ones.

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Section: Magnesium Alloysmentioning

confidence: 96%

Surface Severe Plastic Deformation for Improved Mechanical/Corrosion Properties and Further Applications in the Bio-Medical and Hydrogen Sectors

2023

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Endothelial and smooth muscle cell interaction with hydrothermally treated titanium surfaces

Manivasagam,

Popat

2024

In vitro models

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Cardiovascular diseases (CVDs) remain the leading cause of death worldwide, and the most common form is coronary artery disease (CAD). Treatment options include coronary artery bypass surgery (CABG) or percutaneous heart intervention (PCI), but both have drawbacks. Bare metal stents (BMS) are commonly used to treat CAD; however, they lead to restenosis. Drug-eluting stents (DES) were developed to overcome this limitation; however, they lead to late thrombosis. Hence, there is an urgent need to engineer stent surfaces that selectively prevents smooth muscle cell adhesion and proliferation (restenosis), while promoting endothelial cell adhesion and differentiation (endothelialization), thus enhancing hemocompatibility. In this study, hydrothermal treatment with either sodium hydroxide or sulfuric acid was used to modify the surface of titanium. Titanium surface treated with sulfuric acid led to a micro-nano-surface morphology that selectively promoted endothelial cell adhesion and differentiation while prevented smooth muscle cell proliferation.

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Assessing Mg/Si3N4 biodegradable nanocomposites for osteosynthesis implants with a focus on microstructural, mechanical, in vitro corrosion and bioactivity aspects

Pasha

Rao

Ismail

et al. 2022

Journal of Materials Research and Technology

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Surface-modified WE43 magnesium alloys for reduced degradation and superior biocompatibility

Cited by 6 publications

References 57 publications

Surface Severe Plastic Deformation for Improved Mechanical/Corrosion Properties and Further Applications in the Bio-Medical and Hydrogen Sectors

Surface Severe Plastic Deformation for Improved Mechanical/Corrosion Properties and Further Applications in the Bio-Medical and Hydrogen Sectors

Endothelial and smooth muscle cell interaction with hydrothermally treated titanium surfaces

Assessing Mg/Si3N4 biodegradable nanocomposites for osteosynthesis implants with a focus on microstructural, mechanical, in vitro corrosion and bioactivity aspects

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