Hydrolysis of amphenicol and macrolide antibiotics: Chloramphenicol, florfenicol, spiramycin, and tylosin

Mitchell, Shannon M.; Ullman, Jeffrey L.; Teel, Amy L.; Watts, Richard J.

doi:10.1016/j.chemosphere.2014.08.050

Cited by 125 publications

(58 citation statements)

References 40 publications

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“…Chen et al (2015) found concentrations of CAP up to 28.4 ng L −1 in urban water supplies in Shanghai, China, and Molina‐Avila (2015) found 0.103 mg L −1 in aquaculture waste‐water effluent in the south of the Sonora, Mexico. Mitchell et al (2015) found that hydrolysis of CAP under ambient conditions did not deteriorate its structure.…”

mentioning

confidence: 92%

Degradation of Chloramphenicol in Synthetic and Aquaculture Wastewater Using Electrooxidation

Romero-Soto¹,

Dia

Leyva-Soto³

et al. 2018

J of Env Quality

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Chloramphenicol (CAP) is a broad-spectrum antibiotic widely used in animal farming and aquaculture industries. Despite its ban in many countries around the world, it is still used in several developing countries, with harmful effects on the surrounding aquatic environment. In this study, an electrooxidation process using a Ti/PbO anode was used to investigate the degradation of CAP in both synthetic solution and real aquaculture wastewater. A central composite design was used to determine the optimum conditions for CAP removal. Current intensity and treatment time had the most impact on the CAP removal. These two factors accounted for ∼90% of CAP removal. The optimum conditions found in this study were current intensity of 0.65 A, treatment time of 34 min, and CAP initial concentration of 0.5 mg L. Under these conditions, 98.7% of CAP removal was achieved with an energy consumption of 4.65 kW h m. The antibiotic was not present in the aquaculture wastewater, which received 0.5 mg L of CAP and was treated (by electrooxidation) under the optimum conditions. A complete removal of CAP was obtained after 34 min of treatment. According to these results, electrooxidation presents an option for the removal of antibiotics, secondary compounds, and other organic and inorganic compounds from solution.

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mentioning

confidence: 92%

Degradation of Chloramphenicol in Synthetic and Aquaculture Wastewater Using Electrooxidation

Romero-Soto¹,

Dia

Leyva-Soto³

et al. 2018

J of Env Quality

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“…Florfenicol can be easily hydrolyzed under low pH conditions owing to loss of its amphenicol group (Mitchell, Ullman, Teel, & Watts, ) and is also a gastric irritant that can cause gastric discomfort (El‐Aty et al., ). In addition, FF has not been properly administered for long‐term use in farms, with drug overdoses, administration for incorrect diseases, and medication prescription errors commonly found, causing bacterial resistance to FF (Briggs & Fratamico, ; Zong, Ma, Wang, & Hu, ).…”

Section: Introductionmentioning

confidence: 99%

Preparation, characterization, and pharmacokinetics in swine of a florfenicol enteric formulation prepared using hot‐melt extrusion technology

Wen

Feng

et al. 2018

Vet Pharm & Therapeutics

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The objective of this work was to manufacture an enteric formulation of florfenicol (FF) using hot-melt extrusion (HME) technology and to evaluate its in vitro dissolution and in vivo pharmacokinetics. For the HME process, hypromellose acetate succinate LG (HPMCAS-LG) was the enteric polymer mixed with FF, and the two components were extruded with a standard screw configuration at a speed of 50 rpm. Differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), powder X-ray diffraction (PXRD), and Fourier transform infrared spectroscopy (FT-IR) were performed to characterize the HME extrudate. The release percentage of the enteric formulation in the acidic stage was <10% of the loaded FF, whereas that in the phosphate buffer stage was >80%. Pharmacokinetic evaluations in swine revealed that the enteric formulation had a longer t and MRT than commercially available FF powder (FULAIKA ), indicating that the novel formulation exhibited enteric and sustained release properties. Compared with the commercial product, the relative bioavailability of the enteric formulation reached up to 117.2%. This study suggests that this formulation may have potential for future commercialization.

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“…It was reported that approximately 3300 metric tons of antibiotics were used for human medicine in the U.S. in 2011 (Mitchell et al 2015). However, NOR and other fluoroquinolone antibiotics cannot be completely absorbed by animals or humans.…”

Section: Introductionmentioning

confidence: 99%

Adsorption Characteristics of Norfloxacin by Biochar Prepared by Cassava Dreg: Kinetics, Isotherms, and Thermodynamic Analysis

Feng¹,

Yu²,

Deng³

et al. 2015

BioResources

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Biochars (BC) generated from biomass residues have been recognized as effective sorbents for organic compounds. In this study, biochars as adsorbents for the removal of norfloxacin (NOR) from aqueous solutions were evaluated. Biochars were prepared from cassava dregs at 350 °C, 450 °C, 550 °C, 650 °C, and 750 °C, respectively (labeled as BC350, BC450, BC550, BC650, and BC750). The results showed that the kinetic data were best fitted to the pseudo second-order model, indicating that the sorption was governed by the availability of sorption sites on the biochar surfaces rather than the NOR concentration in the solution. Sorption isotherms of NOR were well described by the Freundlich model, and the Freundlich coefficients (lgkF) increased with the pyrolysis temperature of biochars. Thermodynamic analysis indicated the feasibility and spontaneity of the NOR adsorption process. The NOR adsorption on BC450, BC550, BC650, and BC750 was an endothermic process, while an exothermic process occurred for BC350. FTIR studies further suggested that the adsorption mechanism was possibly attributable to H-bond and π-π interactions between NOR and biochars. Overall, this work constitutes a basis for further research considering the bioavailability and toxicity of antibiotics in the presence of biochar.

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Hydrolysis of amphenicol and macrolide antibiotics: Chloramphenicol, florfenicol, spiramycin, and tylosin

Cited by 125 publications

References 40 publications

Degradation of Chloramphenicol in Synthetic and Aquaculture Wastewater Using Electrooxidation

Degradation of Chloramphenicol in Synthetic and Aquaculture Wastewater Using Electrooxidation

Preparation, characterization, and pharmacokinetics in swine of a florfenicol enteric formulation prepared using hot‐melt extrusion technology

Adsorption Characteristics of Norfloxacin by Biochar Prepared by Cassava Dreg: Kinetics, Isotherms, and Thermodynamic Analysis

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