Hydrogen peroxide formulations and methods of their use for blood oxygen saturation

Ураков, А. Л.

doi:10.55522/jmpas.v11i6.4604

Cited by 8 publications

(21 citation statements)

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“…During the same period of time more than 30 new drugs incorporating hydrogen peroxide were invented in Russia [21]. Most of them are warm alkaline hydrogen peroxide solutions (WAHPSs) [22]. WAHPSs have been reported to consist of the following main ingredients: water, hydrogen peroxide and an alkali (preferably sodium bicarbonate) [20].…”

Section: Resultsmentioning

confidence: 99%

Reprofiling Hydrogen Peroxide from Antiseptics to Pyolytics: A Narrative Overview of the History of Inventions in Russia

Urakov

Уракова

Решетников

et al. 2023

J. Pharm. Res. Int.

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Pyolytics are drugs that dissolve thick pus when applied topically. This group of drugs was discovered in early 21st century in Russia as a result of successful repurposing of antiseptics hydrogen peroxide, sodium bicarbonate and sodium chloride from antiseptics to pyolytics. Prior to this watershed event in pharmacy, the problem of effective treatment of purulent diseases had not been solved. The fact is that before that in the treatment of various purulent diseases mainly antiseptics and disinfectants solutions were used, of which hypertonic sodium chloride solution and 3 - 6% hydrogen peroxide solutions took the leading role as "antipurulent" drugs. However, the use of the known antiseptics and disinfectants solutions provided disinfection of the treated surface, but not dissolution of thick pus masses, as the solutions had no effective pyolytic action. Pyolytic activity, i.e. activity of dissolution of thick pus masses, was fantastically increased in hydrogen peroxide solutions only after the possibility of transformation of "old" drugs into "new" drugs by means of artificial changes in physical and chemical properties of their dosage forms was discovered. The greatest (explosive) effect was achieved by developing warm alkaline hydrogen peroxide solutions enriched with oxygen gas under increased pressure. In chronological order, an overview is given of Russian inventions, which formed the basis for the physicochemical repurposing of hydrogen peroxide solutions into pyolytics as well as the basis of temperature and physicochemical pharmacology and pharmaceutics.

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Section: Resultsmentioning

confidence: 99%

Reprofiling Hydrogen Peroxide from Antiseptics to Pyolytics: A Narrative Overview of the History of Inventions in Russia

Urakov

Уракова

Решетников

et al. 2023

J. Pharm. Res. Int.

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“…Thus, over the past 5 years, a dozen and a half new drugs have been developed, which differ from all known drugs in that they are all enriched with gases that are injected into drugs under high pressure, and /or contain a warm alkaline solution of hydrogen peroxide (WAHPS), which, when interacting with the enzyme catalase in this conditions, decomposes into water and oxygen gas [12][13][14]16,35]. Such drugs, when applied topically, have such local pharmacokinetics and local pharmacodynamics, which significantly distinguishes them from the pharmacokinetics and pharmacodynamics of known drugs [12].…”

Section: Discussionmentioning

confidence: 99%

“…This difference between new drugs and "old" drugs opens up new opportunities in the treatment of many diseases: purulent diseases, wax plugs. vascular catheter thrombosis, ischemia, hypoxia, and respiratory obstruction in COVID-19 [35]. In addition, new drugs allow to discolor the skin in the area of bruises, bloody areas of skin and other tissues, skin and nail plate in the area of the hematoma, to whiten teeth, dental and ceramic products [12,13,[14][15][16]31,32,33,34,35].…”

Section: Discussionmentioning

confidence: 99%

“…vascular catheter thrombosis, ischemia, hypoxia, and respiratory obstruction in COVID-19 [35]. In addition, new drugs allow to discolor the skin in the area of bruises, bloody areas of skin and other tissues, skin and nail plate in the area of the hematoma, to whiten teeth, dental and ceramic products [12,13,[14][15][16]31,32,33,34,35]. Therefore, it is necessary to continue research in this direction in order to get more information about the advantages and disadvantages of drugs enriched with gases both with the help of a WAHPS and/or with the help of overpressure of various gases.…”

Section: Discussionmentioning

confidence: 99%

“…The following is the composition of some new generation of drug solutions. The aerosol is prepared from a solution at a pH of 8.5, osmotic activity of 370-1990 mosmol/l of water and temperature +37-+55°C [35].…”

Section: Ice Liquid Steammentioning

confidence: 99%

See 2 more Smart Citations

Development of New Generation Drugs by Enriching Them with Gases

Urakov

Shabanov

Lovtsova

2023

J. Pharm. Res. Int.

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Until today, the mechanism of action of drugs is traditionally considered without taking into account the physical-chemical properties of dosage forms. However, at the beginning of the 21st century, there were reports that all drugs contain unaccounted gases that enter drugs from the air and affect the quality of drugs. It is shown that the composition and amount of gases in the dosage forms of all drugs changes their mechanical, physical, chemical and physical-chemical properties and the mechanism of action of drugs, especially when applied topically It is reported that changing the content of gases in drug solutions and tablets allows to regulate their mass, volume, specific gravity, porosity, physico-chemical activity and local action on the routes of drug administration. The identification of this pattern allowed to start the production of completely new drugs with a certain gas composition and with a new local pharmacokinetics and a new local pharmacodynamics. The formulations of new drugs in which gas is an auxiliary, formative or main ingredient are given. It is proposed to control the gas composition of medicines as an indicator of their quality and an important factor of their physical-chemical activity. It is proved that the gas in the drug can be not only neutral, but also auxiliary, oppositional, and sometimes the main ingredient. Thus, the control and accounting of the gas contained in drugs will allow the creation of a new generation of drugs in the near future.

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Supplementing traditional drug formulation with the “needed” gases opens the way for the development of a new generation of drugs

Ураков

Shabanov²,

Гуревич

et al. 2023

Psychopharmacology & biological narcology

Self Cite

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The mechanism of action of drugs is traditionally considered the specific action of the main active ingredients. Therefore, to study the mechanism of action of drugs, specialists use selected chemical compounds in chemically pure form. However, at the beginning of the 21st century, studies have reported that the action of drugs in dosage forms (tablets, solutions, etc.) is different from the action of chemically pure ingredients. The fact is that tablets, solutions, and other dosage forms contain not only the main ingredients but also auxiliary, shape-forming ingredients, and gases that supplement the specific action of the main ingredients with their nonspecific action. The gases penetrate the dosage forms from the air; however, selected gases can be introduced into the drugs under excessive pressure. Evidence presents that purposefully altering the gas content of drug tablets and solutions can regulate their mass, volume, specific gravity, porosity, physicochemical activity, and local pharmacokinetics and pharmacodynamics, especially when drugs are administered locally. Examples are shown on how the use of this regularity has allowed the development of a new generation of drugs in Russia, namely, drugs with a specific gas composition. Studies have reported that changing the gas composition of old (registered) drugs may turn them into new drugs. Some drugs invented in Russia included gases in their formulation, which play the role of auxiliary, shape-forming, and even main ingredients. Thus, the gas composition of drugs was proposed as an additional indicator of their quality and an important factor in their physicochemical activity. An expanded list of new generation drugs was hoped for in the near future.

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Hydrogen peroxide formulations and methods of their use for blood oxygen saturation

Cited by 8 publications

References 0 publications

Reprofiling Hydrogen Peroxide from Antiseptics to Pyolytics: A Narrative Overview of the History of Inventions in Russia

Reprofiling Hydrogen Peroxide from Antiseptics to Pyolytics: A Narrative Overview of the History of Inventions in Russia

Development of New Generation Drugs by Enriching Them with Gases

Supplementing traditional drug formulation with the “needed” gases opens the way for the development of a new generation of drugs

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