Reprofiling Hydrogen Peroxide from Antiseptics to Pyolytics: A Narrative Overview of the History of Inventions in Russia

Urakov, Aleksandr; Уракова, Н. А.; Решетников, А. П.; Shchemeleva, A.; Shabanov, Petr D.; Lovtsova, Lubov; Самородов, Александр В.; Fisher, Evgeny; Stolyarenko, Anastasia; Suntsova, Daria; Yagudin, Ilnur; Muhutdinov, Nikita

doi:10.9734/jpri/2023/v35i67333

Cited by 4 publications

(1 citation statement)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Идеализация лекарств стала причиной того, что в философии фармации и фармакологии рассматриваемый фармацевтический продукт имеет идеальное высокое качество. При этом подразумевается, что в нем полностью отсутствуют примеси, оно не смешивается с иными активными веществами, не представляет собой определенный материальный предмет в определенном агрегатном состоянии с определенными физическими, химическими и другими свойствами и не содержит газы [10,20,35,36].…”

Section: химическая философия фармации и фармакологии преимущества и ...unclassified

Idealization in pharmacology and pharmacy: Symbol of the chemical formula of one molecule of a substance and a real pharmaceutical product

Urakov,

Shabanov

2024

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

The fundamentally different essence of two levels of information used in modern pharmacy, pharmacology and medicine for operations related to theoretical reasoning about medicines and the actual practice of their use in the treatment of specific patients is reported. In particular, the essence of theoretical information about medicines and norms of their use in accordance with the standards of medical care is analyzed. It is shown that the information about medicines and standards of medical care, dominating nowadays in textbooks, reference books, encyclopedias, scientific articles and normative and technical documents, is built on the idealized essence of chemically pure substances and idealized essence of their interaction with an idealized virtual patient. In this regard, in the fields of pharmacy, pharmacology, and chemistry, physics, and materials science, researchers to date have traditionally represented chemical elements (and drugs) by certain chemical formulas, names, and symbols for their molecules. Moreover, in pharmacy and pharmacology, the structural formula of one molecule of only one chemical substance belonging to the group of so-called main active substances most often plays this role. As a rule, this chemical symbol of its molecule is identified with the real substance itself. It is assumed that the substance in question is of ideal high quality, it is completely free of any impurities, it is not combined with other substances and does not represent a certain pharmaceutical product (it is not a tablet, not a solution, not an ointment, not an aerosol, etc.), and is not manufactured by a certain pharmaceutical company according to a certain recipe. At the same time, modern pharmaceutical products are not separate molecules, not pure chemical reagents, but all sorts of mixtures of different substances of different quality in different ratios. At the same time, each pharmaceutical product of each manufacturing plant and each series number has only inherent and unique mechanical, physical, chemical, physico-chemical properties and quality indicators. Therefore, the idealized essence of drugs is far from the essence of real pharmaceutical products. The chemical name and chemical formula are just a symbol of one molecule of a chemical element, reflecting its idealized chemical essence, but not the essence of a real "tablet", "ampoule" and/or "tube" with it. In turn, the virtual patient of average gender, average age, average health status, with a body weight of about 70 kg implied by the standards of medical care is just an idealized object of interaction with an idealized "medicine". In this regard, the study of the relationship between the idealized and real essence of drugs and patients is a crucial part of the problem of the relationship between theory and reality in pharmacy, pharmacology and in medicine.

show abstract

Section: химическая философия фармации и фармакологии преимущества и ...unclassified

Idealization in pharmacology and pharmacy: Symbol of the chemical formula of one molecule of a substance and a real pharmaceutical product

Urakov,

Shabanov

2024

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

show abstract

Method and technology for drug repurposing based on changes in the physicochemical properties of dosage forms: experience of use in Russia

Urakov

2023

Psychopharmacology & biological narcology

View full text Add to dashboard Cite

Controlled local hyperthermia and hypothermia are important factors in drug pharmacodynamics and pharmacokinetics because changing the temperature of drugs changes their physicochemical properties. In this regard, a controlled change in the temperature of the drug and/or the body part with which the drug interacts, relative to the level of human body temperature (hyperthermia or hypothermia) forms the basis of temperature pharmacology. To analyze the authors publications on the problem of methodology and technology for repurposing drugs based on changes in the physicochemical properties of dosage forms. A controlled change in the temperature of the drug and/or the part of the body with which the drug interacts; a change in acid (alkaline), osmotic activity, and the degree and quality of carbonation and/or oxygen-forming activity of medicinal solutions; and a change in the concentration of medicinal solution ingredients. On the basis of the used methods, the reprofiling of a number of drugs has been achieved. The author proposed reprofiling a 4% potassium chloride solution from the group of macroelements and microelements used to regulate acid-base balance with a resorptive effect (when administered intravenously to the whole body) into a group of vasoconstrictive drugs used to stop bleeding when applied to by a single irrigation of the bleeding surface. Cooling certain drugs and tissues at their interaction sites to 18C20C (via an ice pack or its substitute) inhibits metabolism and function, ensuring the conversion of many drugs into anti-ischemic drugs by reducing the need for tissues in oxygen. A targeted change in the physicochemical properties of known drugs combined with local hyperthermia allows them to be converted into expectorant, pyrolytic (astringent), hemolytic, thrombolytic (hemostatic), detergent, bleaching, cleaning, and other drugs, including antiseptic and cauterizing (necrotizing) drugs, very reliably, quickly, and inexpensively. Thus, 40 years ago, pharmacologists of the Russian Federation established the foundation for a novel method of drug development known today as repurposing of existing drugs. Today, it is evident that reprofiling may rapidly, inexpensively, and effectively give existing drugs a new purpose.

show abstract

Pyolytics as a product of the physical–chemical repurposing of antiseptics and an alternative to larval therapy for chronic wounds

Urakov,

Urakova,

Reshetnikov

et al. 2024

Rev Clin Pharm Drug Ther

View full text Add to dashboard Cite

It is shown that traditional treatment of chronic wounds is a course of daily single procedures of cleansing the wound surface from purulent-necrotic masses by mechanical and medicinal methods, accompanied by regular renewal of wound dressings. In this case, the procedures of medicinal wound cleansing last 10 - 15 minutes between the replacement of "old" wound dressings with "new" wound dressings. According to the established practice, medicinal sanitation of infected and purulent wounds during dressings consists in irrigation of the wound surface with cleansing solutions, solutions of antiseptics and/or antibiotics. In severe cases, the above therapy is supplemented with live larvae of the necrophage fly, which are injected into purulent-necrotic masses and left in them under wound dressings until complete cleansing of wounds from pus. Nevertheless, the effectiveness of the generally accepted course treatment of chronic wounds remains insufficiently high. It is reported that the use of pyolytics and their supplementation with wound dressings made in the form of warm wet compresses, which create a local greenhouse effect in wounds, can accelerate the healing of chronic wounds. It is shown that pyolytics is a group of antiseptics developed in Russia, which are warm alkaline solutions of hydrogen peroxide, which in interaction with purulent-necrotic masses very quickly dissolve and foam them. As a result of interaction with pyolytics, thick purulent immediately turns into fluffy oxygenated foam. It is shown that pyolytics have been developed due to physicochemical repurposing of aqueous solutions of sodium hydrogen carbonate and hydrogen peroxide. To accelerate the healing of chronic wounds it was proposed to irrigate the surface of chronic wounds with a solution of 3% hydrogen peroxide and 2-10% sodium bicarbonate, heated to a temperature of +37 - +45C, having alkaline activity at pH 8.4 - 8.5 and enriched with dissolved carbon dioxide or oxygen (due to excess pressure of 0.2 ATM). The essence of the invented technology of treatment of chronic wounds with the use of pyolytics is indicated and the results of treatment of chronic wounds with pyolytics in combination with warm moist dressings-compresses are given, which confirm the presence of wound-healing effect. Consequently, physical and chemical re-profiling of antiseptics allows turning them into effective pyolytics, and the combination of pyolytics with warm wound dressings made in the form of warm moist compresses, which create a local greenhouse effect in wounds, allows accelerating the healing of chronic wounds.

show abstract

Reprofiling Hydrogen Peroxide from Antiseptics to Pyolytics: A Narrative Overview of the History of Inventions in Russia

Cited by 4 publications

References 31 publications

Idealization in pharmacology and pharmacy: Symbol of the chemical formula of one molecule of a substance and a real pharmaceutical product

Idealization in pharmacology and pharmacy: Symbol of the chemical formula of one molecule of a substance and a real pharmaceutical product

Method and technology for drug repurposing based on changes in the physicochemical properties of dosage forms: experience of use in Russia

Pyolytics as a product of the physical–chemical repurposing of antiseptics and an alternative to larval therapy for chronic wounds

Contact Info

Product

Resources

About