Hydrogels Based on (Dimethylamino)ethylacrylate (Dmaea) and N,n'-Dimethylacrylamide (Nndmaam): Synthesis, Characterization, and Swelling Behavior

Abstract

Hydrogels of 2-(dimethylamino)ethylacrylate (DMAEA) with N,N′-dimethyl acrylamide (NNDMAAm) were synthesized by solution free-radical polymerization at different feed mol ratios. These copolymers were completely water-insoluble. Polymers were characterized by elemental analysis, FT-IR spectroscopy, thermogravimetric analysis (TGA), and scanning electron microscopy (SEM). The monomer reactivity ratios were determined by Kelen-Tüdos method. According to that, the monomer reactivity ratios for poly(DMAEA-co-NNDMAAm) were r 1 = 0.288 (M 1 =DMAEA) and r 2 = 1.460 (M 2 =NNDMAAm), (r 1 x r 2 = 0.419). Low critical solution temperatures (LCST) values of hydrogels are around 60°C, which was significantly higher than that poly(NIPAAm) and increased with increasing of hydrophilic DMAEA unit content in the copolymers. The hydrogels achieved a water-absorption value of 188 g of water/g of dry polymer (xerogel) in distilled water. Effects of time, temperature, pH, salt concentration, cross-linking concentration, and solvent polarity on the water absorption were studied. Experimental results indicated that the copolymer poly(DMAEA-co-NNDMAAm) with a feed mol ratio 2:1 presents the best swelling properties.

Tuning the Molar Composition of “Charge‐Shifting” Cationic Copolymers Based on 2‐(N,N‐Dimethylamino)Ethyl Acrylate and 2‐(tert‐Boc‐Amino)Ethyl Acrylate

“…Same behavior has been observed starting from DMAEA and methyl acrylate (MA) comonomers . When DMAEA is combined with an acrylamide monomer such as N,N ‐dimethyl acrylamide, 2‐acrylamido‐2‐methyl‐1‐propanesulfonic acid, and 3‐aminopropyl methacrylamide, the acrylamide possesses a much higher reactivity ratio and a higher tendency of homopropagation. Therefore, chain growth reaction proceeds predominantly by the addition of DMAEA monomer to polyacrylamide macroradicals yielding statistical copolymers.…”

Fabrication of biodegradable hydrogels based on chitosan and poly(azomethine‐urethane) containing phenyl triazine for drug delivery

“…Besides, it was clearly seen from swelling data that PHE‐MET‐LDI has the highest swelling capacity in all pH media. This could be mainly probably due to the higher molecular weight, 41 microsphere structures, and lower contact angle 42 values of this LDI‐containing hydrogel.…”