Fabrication of biodegradable hydrogels based on chitosan and poly(azomethine‐urethane) containing phenyl triazine for drug delivery

Abstract

A series of biodegradable hydrogels based on chitosan and polyurethanes was fabricated to be applied to the drug delivery application, and the fabricated hydrogels were characterized by using SEM, and FT‐IR techniques. Polyurethanes were also synthesized by using the different diisocyanates, and the diisocyanate's effect on the properties of the hydrogels was clarified. The mechanical and thermal properties, % swelling capacity, biodegradation, and hydrophilic or hydrophobic behaviors of the chitosan and polyurethane hydrogels were also clarified. The fabricated hydrogels were demonstrated good biodegradable and antibacterial behaviors. The cumulative drug release of the hydrogels was revealed that they have around 50% drug release capacity, and according to the obtained results, the chitosan and polyurethane‐based hydrogels have a potential drug delivery application of 5‐fluorouracil.

Structural Modulation of Chitosan/Polyacrylic Acid‐based Hydrogels for Optimized Controlled Drug Release Performance

“…This may be because the electrostatic interaction formed between the amino group of chitosan in the hydrogel and the phospholipid component of the bacterial cell membrane causes damage to the bacterial cell membrane and inhibits the growth of the bacteria. [51] The antibacterial activity of the hydrogel has also been demonstrated in the inhibition circle test (Figure 10b). The growth of the bacteria on the agar plates indicated that the bacteria were in an active growth phase.…”