Hydrogels Based Drug Delivery Synthesis, Characterization and Administration

Onaciu, Anca; Munteanu, Raluca; Moldovan, Alin; Moldovan, Cristian; Berindan‐Neagoe, Ioana

doi:10.3390/pharmaceutics11090432

Cited by 76 publications

(58 citation statements)

References 241 publications

(179 reference statements)

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“…Smart hydrogels have morphological and functional characteristics that change in the presence of various external stimuli, essential properties for the applications in the field of drug delivery systems. These hydrogels are designed in order to obtain systems with controlled and sustained drug release and with lowest side effects [ 78 , 79 , 80 , 81 , 82 , 83 ].…”

Section: Cellulose-based Hydrogels In Drug Deliverymentioning

confidence: 99%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

112

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Hydrogels, three-dimensional (3D) polymer networks, present unique properties, like biocompatibility, biodegradability, tunable mechanical properties, sensitivity to various stimuli, the capacity to encapsulate different therapeutic agents, and the ability of controlled release of the drugs. All these characteristics make hydrogels important candidates for diverse biomedical applications, one of them being drug delivery. The recent achievements of hydrogels as safe transport systems, with desired therapeutic effects and with minimum side effects, brought outstanding improvements in this area. Moreover, results from the utilization of hydrogels as target therapy strategies obtained in clinical trials are very encouraging for future applications. In this regard, the review summarizes the general concepts related to the types of hydrogel delivery systems, their properties, the main release mechanisms, and the administration pathways at different levels (oral, dermal, ocular, nasal, gastrointestinal tract, vaginal, and cancer therapy). After a general presentation, the review is focused on recent advances in the design, preparation and applications of innovative cellulose-based hydrogels in controlled drug delivery.

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Section: Cellulose-based Hydrogels In Drug Deliverymentioning

confidence: 99%

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Ciolacu¹,

Nicu²,

Ciolacu

2020

Materials

112

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“…Scanning electron microscopy (SEM) is by far the most popular technique used to perform morphological characterization of hydrogels. In this context, SEM allows the identification of pore formation and size, crosslinking status of a hydrogel and evaluate the effect of loading molecules in general structure of matrices [ 89 ]. Although SEM is widely used, it has a limitation capacity of generation two-dimensional projections.…”

Section: Hydrogels As Delivery Systems In Scimentioning

confidence: 99%

“…To overcome this limitation, laser scanning confocal microscopy has been introduced in the field. In addition, LSCM can be combined with fluorescent dyes, such as fluorescent recovery after bleaching (FRAP) to study the diffusivity from hydrogels, which will contribute to predict the release profile in DS [ 89 , 90 ]. Spectroscopic methods include Fourier transforms infrared (FTIR) spectroscopy is an analytical method used to study the bonding structure of atoms based on the interaction between infrared irradiation with matter [ 91 ].…”

Section: Hydrogels As Delivery Systems In Scimentioning

confidence: 99%

Hydrogels as delivery systems for spinal cord injury regeneration

Silva

Sousa

Salgado

2021

Materials Today Bio

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Spinal cord injury is extremely debilitating, both at physiological and psychological levels, changing completely the patient's lifestyle. The introduction of biomaterials has opened a new window to develop a therapeutic approach to induce regeneration after injury due to similarities with extracellular matrix. Particularly, hydrogels have the ability to support axonal growth and endogenous regeneration. Moreover, they can also act as potential matrixes in which to load and deliver therapeutic agents at injury site. In this review, we highlight some important characteristics to be considered when designing hydrogels as delivery systems (DS), such as rheology, mesh size, swelling, degradation, gelation temperature and surface charge. Additionally, affinity-based release systems, incorporation of nanoparticles, or ion-mediated interactions are also pondered. Overall, hydrogel DS aim to promote a sustained, controlled and prolonged release at injury site, allowing a targeted oriented action of the therapeutic agent that will be used.

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“…SERS technique is increasingly employed for prostate cancer detection from body fluids. The most preferred SERS substrates are silver nanoparticles [114], gold nanoparticles targeting different circulating molecules (non-coding RNA, PSA, MUC4, IgG) [115], polymeric membranes [112] and microfluidic devices [116,117].…”

Section: Conclusion and Future Perspectivesmentioning

confidence: 99%

MiRNA-Based Inspired Approach in Diagnosis of Prostate Cancer

Munteanu

Onaciu

et al. 2020

Medicina

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Prostate cancer is one of the most encountered cancer diseases in men worldwide and in consequence it requires the improvement of therapeutic strategies. For the clinical diagnosis, the standard approach is represented by solid biopsy. From a surgical point of view, this technique represents an invasive procedure that may imply several postoperative complications. To overcome these impediments, many trends are focusing on developing liquid biopsy assays and on implementing them in clinical practice. Liquid samples (blood, urine) are rich in analytes, especially in transcriptomic information provided by genetic markers. Additionally, molecular characterization regarding microRNAs content reveals outstanding prospects in understanding cancer progression mechanisms. Moreover, these analytes have great potential for prostate cancer early detection, more accurate prostate cancer staging and also for decision making respecting therapy schemes. However, there are still questionable topics and more research is needed to standardize liquid biopsy-based techniques.

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Hydrogels Based Drug Delivery Synthesis, Characterization and Administration

Cited by 76 publications

References 241 publications

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Cellulose-Based Hydrogels as Sustained Drug-Delivery Systems

Hydrogels as delivery systems for spinal cord injury regeneration

MiRNA-Based Inspired Approach in Diagnosis of Prostate Cancer

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