Hydrogel Nanoparticle as a Functional Coating Layer in Biosensing, Tissue Engineering, and Drug Delivery

Cho, Hee-Joo; Jeon, Seung Hwan; Yang, Junghyeok; Baek, Song Yi; Kim, Doeun

doi:10.3390/coatings10070663

Cited by 10 publications

(9 citation statements)

References 142 publications

(245 reference statements)

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“…Biomaterials at present are used in a variety of forms such as hydrogels, sponges, scaffolds, electrospun mesh and so on [ 3 ]. Out of all these, hydrogels have emerged as the most promising candidate for use in biomedical applications such as targeted drug delivery and tissue regeneration due to favorable biocompatibility, biodegradability and low cytotoxicity [ 4 , 5 ]. Hydrogels are essentially porous, with matching physical and mechanical properties to the extracellular matrix (ECM), allowing for the transport of oxygen and moisture, and movement of nutrients, payloads such as drugs, genes and other biomolecules [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Effect of Iron-Oxide Nanoparticles Impregnated Bacterial Cellulose on Overall Properties of Alginate/Casein Hydrogels: Potential Injectable Biomaterial for Wound Healing Applications

et al. 2020

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In this study we report the preparation of novel multicomponent hydrogels as potential biomaterials for injectable hydrogels comprised of alginate, casein and bacterial cellulose impregnated with iron nanoparticles (BCF). These hydrogels demonstrated amide cross-linking of alginate–casein, ionic cross-linking of alginate and supramolecular interaction due to incorporation of BCF. Incorporation of BCF into the hydrogels based on natural biopolymers was done to reinforce the hydrogels and impart magnetic properties critical for targeted drug delivery. This study aimed to improve overall properties of alginate/casein hydrogels by varying the BCF loading. The physico-chemical properties of gels were characterized via FTIR, XRD, DSC, TGA, VSM and mechanical compression. In addition, swelling, drug release, antibacterial activity and cytotoxicity studies were also conducted on these hydrogels. The results indicated that incorporation of BCF in alginate/casein hydrogels led to mechanically stronger gels with magnetic properties, increased porosity and hence increased swelling. A porous structure, which is essential for migration of cells and biomolecule transportation, was confirmed from microscopic analysis. The porous internal structure promoted cell viability, which was confirmed through MTT assay of fibroblasts. Moreover, a hydrogel can be useful for the delivery of essential drugs or biomolecules in a sustained manner for longer durations. These hydrogels are porous, cell viable and possess mechanical properties that match closely to the native tissue. Collectively, these hybrid alginate–casein hydrogels laden with BCF can be fabricated by a facile approach for potential wound healing applications.

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Section: Introductionmentioning

confidence: 99%

Effect of Iron-Oxide Nanoparticles Impregnated Bacterial Cellulose on Overall Properties of Alginate/Casein Hydrogels: Potential Injectable Biomaterial for Wound Healing Applications

et al. 2020

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“…SEM micrographs further confirmed the entrapment of BBR-NPs within the matrix of the nanocomposite pill. However, the variation between the nanoparticles size obtained from SEM micrograph and DLS The variation between the mean particle size obtained from DLS and electron microscopy can be attributed to the swelling and fusion of BBR-NPs during the SLA process [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

3D printing of nanocomposite pills through desktop vat photopolymerization (stereolithography) for drug delivery reasons

et al. 2022

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Background The desktop vat polymerization process or stereolithography printing is an ideal approach to develop multifunctional nanocomposites wherein a conventional solid dosage form is used as a reservoir for compliant administration of drug-loaded nanocarriers. Methods In this study, a nanocomposite drug delivery system, that is, hydrogel nanoparticles of an approved nutraceutical, berberine entrapped within vat photopolymerized monoliths, was developed for drug delivery applications. For the fabrication of the nanocomposite drug delivery systems/pills, a biocompatible vat photopolymerized resin was selected as an optimum matrix capable of efficiently delivering berberine from stereolithography mediated 3D printed nanocomposite pill. Results The obtained data reflected the efficient formation of berberine-loaded hydrogel nanoparticles with a mean particle diameter of 95.05 ± 4.50 nm but low loading. Stereolithography-assisted fabrication of monoliths was achieved with high fidelity (in agreement with computer-aided design), and photo-crosslinking was ascertained through Fourier-transform infrared spectroscopy. The hydrogel nanoparticles were entrapped within the pills during the stereolithography process, as evidenced by electron microscopy. The nanocomposite pills showed a higher swelling in an acidic environment and consequently faster berberine release of 50.39 ± 3.44% after 4 h. The overall results suggested maximal release within the gastrointestinal transit duration and excretion of the exhausted pills. Conclusions We intended to demonstrate the feasibility of making 3D printed nanocomposite pills achieved through the desktop vat polymerization process for drug delivery applications.

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“…Both the front sides of the gel and ACC were clamped using the tensile machine and displaced at a velocity of 100 mm min –1 . The interfacial toughness was calculated as 2 F / w , − where F is the steady force during peeling and w is the sample width.…”

Section: Experimental Sectionmentioning

confidence: 99%

Highly Deformable, Conductive Double-Network Hydrogel Electrolytes for Durable and Flexible Supercapacitors

Liu

Zhong

et al. 2022

ACS Appl. Mater. Interfaces

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Developing flexible energy storage devices with the ability to retain capacitance under extreme deformation is promising but remains challenging. Here, we report the development of a durable supercapacitor with remarkable capacitance retention under mechanical deformation by utilizing a physical double-network (DN) hydrogel as an electrolyte. The first network is hydrophobically associating polyacrylamide cross-linked by nanoparticles, and the second network is Zn2+ cross-linked alginate. Through soaking such a DN hydrogel into a high concentration of ZnSO4 solution, a highly deformable electrolyte with good conductivity is fabricated, which also shows adhesion to diverse surfaces. Directly attaching the hydrogel electrolyte to two pieces of an active carbon cloth facilely produces a flexible supercapacitor with a high specific capacitance and theoretical energy density. Remarkable capacitance retention under tension, compression, and bending is observed for the supercapacitor, which can also maintain above 87% of the initial capacitance after 4000 charge–discharge cycles. This study provides a simple way to fabricate hydrogel electrolytes for deformable yet durable supercapacitors, which is expected to inspire the development of next-generation flexible energy storage devices.

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Hydrogel Nanoparticle as a Functional Coating Layer in Biosensing, Tissue Engineering, and Drug Delivery

Cited by 10 publications

References 142 publications

Effect of Iron-Oxide Nanoparticles Impregnated Bacterial Cellulose on Overall Properties of Alginate/Casein Hydrogels: Potential Injectable Biomaterial for Wound Healing Applications

Effect of Iron-Oxide Nanoparticles Impregnated Bacterial Cellulose on Overall Properties of Alginate/Casein Hydrogels: Potential Injectable Biomaterial for Wound Healing Applications

3D printing of nanocomposite pills through desktop vat photopolymerization (stereolithography) for drug delivery reasons

Highly Deformable, Conductive Double-Network Hydrogel Electrolytes for Durable and Flexible Supercapacitors

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