Hydrodynamics of the pyeloureter of the pig: An experimental study of the relationship between pressure and flow in the normal, in the obstructed, and in the transsected pyeloureter

Mortensen, J.

doi:10.1002/nau.1930050110

Neurourology and Urodynamics

1986

DOI: 10.1002/nau.1930050110

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Hydrodynamics of the pyeloureter of the pig: An experimental study of the relationship between pressure and flow in the normal, in the obstructed, and in the transsected pyeloureter

J. Mortensen

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Cited by 16 publications

References 133 publications

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The impact of unilateral ureteral obstruction on pelvic and parenchymal transit times in the pig kidney

Frøkiær¹,

Jensen

Djurhuus

et al. 1990

Eur J Nucl Med

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In 10 female pigs a partial unilateral ureteral obstruction was investigated for 3 weeks. The pigs were monitored with 131I-iodo-hippuran scintigraphies before obstruction and once a week during the course of obstruction. Parenchymal and pelvic mean transit times were calculated by deconvolution analysis. Before the pigs were killed, pelvic pressure and volume were measured. During the course of obstruction there was a slight, but significant (P less than or equal to 0.05) difference in renographical split function between the 2 sides. Parenchymal transit times increased moderately ipsilaterally during the 1st and 2nd week after obstruction and a significant difference (P less than 0.02) appeared in the 2nd week compared to the contralateral side, which was unchanged during the course of obstruction. Pelvic transit times increased steadily ipsilaterally during the course of obstruction and the opposite took place contralaterally. A fair correlation (r = 0.65) was found between parenchymal transit time and pelvic baseline pressure. Pelvic transit times were prolonged at any time after obstruction and significantly correlated to the presence of obstruction. The study suggests that interpretation of the obstructed renogram will encounter analysis of both parenchymal and pelvic transit times in cases where renal function is moderately reduced.

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The impact of unilateral ureteral obstruction on pelvic and parenchymal transit times in the pig kidney

Frøkiær¹,

Jensen

Djurhuus

et al. 1990

Eur J Nucl Med

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Pharmacological effect on pyeloureteric dynamics with a clinical perspective: a review of the literature

et al. 2006

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We searched to review experimental and clinical trials concerning the capabilities of impacting on the ureteric and pelvic activity by means of pharmacological stimulation. Ureteropyeloscopy may cause high renal pelvic pressure. The normal pressure is in the range of 5-15 mmHg whereas pressure of 410 mmHg has been measured during endoscopy. The threshold pressure for intrarenal reflux is about 35 mmHg. Studies in animals have revealed that high renal pelvic pressures may cause permanent damage to the renal parenchyma. Furthermore, it has been demonstrated that elevated pressures may entail an increased risk of several complications related to endourological procedures including bleeding, perforation and infection. In other words, means by which intrarenal pressure could be lowered during endourological procedures might be beneficial with respect to clinical outcomes. In vitro experiments support the existence of different receptors in the ureter and renal pelvis. The ureteric and pelvic responses to the corresponding neurotransmitters have been determined. It seems that alpha-adrenergic and cholinergic agents are stimulating whereas beta-adrenergic agents inhibit ureteric activity. The effect may depend on the mode of administration. Drugs exerting advantageous effects in the pyeloureter may cause undesirable systemic side effects when administered intravenously. In animal studies, renal pelvic pressure can be significantly lowered by topical administration of beta-adrenergic agonists without systemic side effects. In vivo human studies are necessary to clarify the exact dose-response relationship and the degree of urothelial absorption of a drug before clinical use may be adopted.

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Local and Systemic Effects of Endoluminal Pelvic Perfusion of Isoproterenol: A Dose Response Investigation in Pigs

et al. 2007

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Hydrodynamics of the pyeloureter of the pig: An experimental study of the relationship between pressure and flow in the normal, in the obstructed, and in the transsected pyeloureter

Cited by 16 publications

References 133 publications

The impact of unilateral ureteral obstruction on pelvic and parenchymal transit times in the pig kidney

The impact of unilateral ureteral obstruction on pelvic and parenchymal transit times in the pig kidney

Pharmacological effect on pyeloureteric dynamics with a clinical perspective: a review of the literature

Local and Systemic Effects of Endoluminal Pelvic Perfusion of Isoproterenol: A Dose Response Investigation in Pigs

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