“…The combination of the mechanical, thermal, and chemical effects generated during a cavitation bubble collapse is widely considered to be responsible for the removal of pollutants [22] . Because HC is artificially generated by hydrodynamic cavitation reactors (HCRs), therefore, the design of high-performance HCRs is extremely vital for the effectiveness and economical efficiency of HC technology [23] . Unlike conventional HCRs (e.g., Venturi tubes or orifice plates) which have been widely utilized on a laboratory scale [24] , advanced rotational HCRs (ARHCRs) are found to yield significant effects in large numbers of scaled-up applications, such as water disinfection [25] , [26] , [27] , [28] , [29] , [30] , decomposition of waste-activated sludge (WAS) [31] , [32] , [33] , [34] , degradation of organic matter [35] , [36] , [37] , biofuel synthesis [38] , [39] , [40] , fibrillation [41] , intensification of biogas production [42] , and delignification [43] .…”