Hydrocortisone inhibits IFN-γ production in equine, ovine, and bovine PBMCs

McCandless, Erin E.; Sharath, K.; Mwangi, Duncan M.; Sly, Laurel M.; Franz, L.C.

doi:10.1016/j.vetimm.2012.12.012

Cited by 4 publications

(3 citation statements)

References 28 publications

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“…49 Corticosteroid treatment results in decreased production of Interferon-γ in PBMC. 50 IFN-γ has also been implicated in steroid resistance in asthma by activation of MyD88-dependent pathways in macrophages. 51 Hence, the possible mechanism could be role of IFN-γ in downstream signaling of IL-23, hence contributing to pathogenesis of GVHD and involvement of IFN-γ in response to steroids.…”

Section: P=000002mentioning

confidence: 99%

Risk model incorporating donor IL6 and IFNG genotype and gastrointestinal GVHD can discriminate patients at high risk of steroid refractory acute GVHD

Alam

Atenafu

et al. 2015

Bone Marrow Transplant

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Steroid refractory acute GVHD (SR aGVHD) is associated with high morbidity and mortality. This study attempted to generate a risk model for SR aGVHD using 259 single nucleotide polymorphisms (SNPs) in 53 genes of recipients and donors. A total of 268 patients with aGVHD who were treated with systemic steroids were included. Patients were randomly divided into training (n = 180) and validation sets (n = 88). Clinical risk factors were also evaluated. In the training set, 85 (47.2%) developed SR aGVHD. Gastrointestinal involvement (P o0.0001) and donor genotypes of IL6 (rs1800797; P = 6.2 × 10 −4 ) and IFNG (rs2069727; P = 4.4 × 10 −4 ) were significant risk factors. Scores were assigned to the above risk factors. Patients were divided into low (score 0, n = 74) vs high risk (scores 1-3; n = 106) in risk model. Higher incidence of SR aGVHD was noted in the high risk (61.3%) vs the low-risk group (27%; P o 0.0001, odds ratio (OR) 4.28). Predictive effect of risk model was replicated in the validation set (P = 0.0045, OR 3.74). This risk model was associated with response to therapy, overall and GVHD-specific survival and non-relapse mortality. Our study suggested that this risk model could identify patients at high risk of SR aGVHD with donor genotype of IL6 (rs1800797) and IFNG (rs2069727) along with gastrointestinal involvement of aGVHD.

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Section: P=000002mentioning

confidence: 99%

Risk model incorporating donor IL6 and IFNG genotype and gastrointestinal GVHD can discriminate patients at high risk of steroid refractory acute GVHD

Alam

Atenafu

et al. 2015

Bone Marrow Transplant

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“…Hydrocortisone (1, 10 and 100 mg/l) has been shown to supress interferon‐γ production by equine peripheral blood mononuclear cells in vitro (McCandless et al . ).…”

Section: Physiological Effects Of Glucocorticoidsmentioning

confidence: 97%

“…Glucocorticoids also interfere with cytokine signalling and the resultant clinical effects seen include reductions in fibrin deposition, oedema formation, leucocyte migration, phagocytic activity and capillary proliferation (Boothe and Mealey 2012). Hydrocortisone (1, 10 and 100 mg/l) has been shown to supress interferon-c production by equine peripheral blood mononuclear cells in vitro (McCandless et al 2013).…”

Section: Physiological Effects Of Glucocorticoidsmentioning

confidence: 99%

Review of glucocorticoid therapy in horses. Part 1: Pharmacology

Cuming

Groover

Wooldridge

et al. 2016

Equine Veterinary Education

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Summary This article is the first in a three part review series examining glucocorticoid use in treatment of medical conditions and musculoskeletal disorders of the horse. This article provides a review of the structure and function of corticosteroids together with a summary of the available literature pertaining to the pharmacodynamics, pharmacokinetics and indications for use of, and adverse effects associated with, glucocorticoids currently available for use by equine veterinarians.

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Modulation of TNF-α, IL-1Ra and IFN-γ in equine whole blood culture by glucocorticoids

Schrödl

Abraham²

2019

Veterinary Immunology and Immunopathology

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Hydrocortisone inhibits IFN-γ production in equine, ovine, and bovine PBMCs

Cited by 4 publications

References 28 publications

Risk model incorporating donor IL6 and IFNG genotype and gastrointestinal GVHD can discriminate patients at high risk of steroid refractory acute GVHD

Risk model incorporating donor IL6 and IFNG genotype and gastrointestinal GVHD can discriminate patients at high risk of steroid refractory acute GVHD

Review of glucocorticoid therapy in horses. Part 1: Pharmacology

Modulation of TNF-α, IL-1Ra and IFN-γ in equine whole blood culture by glucocorticoids

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