Review of glucocorticoid therapy in horses. Part 1: Pharmacology

Cuming, Rosemary; Groover, Erin S.; Wooldridge, Anne A.; Caldwell, Fred

doi:10.1111/eve.12555

Cited by 10 publications

(15 citation statements)

References 84 publications

(179 reference statements)

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“…An additional explanation might be the treatment with dexamethasone by the referring veterinarian. Administration of glucocorticoids, like dexamethasone induces leukocyte release from bone marrow, demargination and decreased destruction in horses (Cuming et al., 2018). But so far, no data regarding the leukocyte response after acute spinal trauma and after glucocorticoid administration in zebras exist.…”

Section: Discussionmentioning

confidence: 99%

Schiff‐Sherrington syndromein a 7‐year‐old zebra mare (Equus quagga)

Frers

Hellige

Franke

et al. 2022

Equine Veterinary Education

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Traumatic vertebral injuries are typically caused by incidents such as collision with immovable objects or a fall. Although injury to the vertebral column may occur at any site, in adult horses, the caudal neck and caudal thoracic (T15-18) are the most affected regions.In contrast, traumatic vertebral injury of the cranial to mid-thoracic and lumbar (L) spine is rare in equids (Feige et al., 2000;Robertson & Samii, 2012).The degree and type of the neurological abnormalities depend on location, severity of the insult and damage of the spinal cord.Cases may either be asymptomatic without any neurological signs or may exhibit severe tetraparesis or tetraplegia. Injuries to the caudal cervical (C) or thoracic spinal cord more likely lead to lateral recumbency compared with lesions of the cranial cervical or lumbosacral spine (Feige et al., 2000). Lesions of the spinal cord localised between the 2nd thoracic vertebra and the 3rd lumbar vertebra may lead to pelvic limb paralysis with concurrent extensor rigidity of the thoracic limbs. This condition is referred to as Schiff-Sherrington syndrome (Coates & O'Brien, 2004;deLahunta, 1983). To the authors' knowledge only two cases of Schiff-Sherrington syndrome in horses have been reported (Chiapetta et al., 1985;Lhamas et al., 2015).

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Section: Discussionmentioning

confidence: 99%

Schiff‐Sherrington syndromein a 7‐year‐old zebra mare (Equus quagga)

Frers

Hellige

Franke

et al. 2022

Equine Veterinary Education

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“…15 The pharmacokinetics and pharmacodynamics of different GC used in horses have been reviewed recently. 16…”

Section: Mechanisms Of Action Of Gcmentioning

confidence: 99%

Glucocorticoid treatment in horses with asthma: A narrative review

Mainguy-Seers

Lavoie

2021

Veterinary Internal Medicne

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Despite substantial research efforts to improve the treatment and outcome of horses with asthma, glucocorticoids (GC) remain the cornerstone of drug treatment of this prevalent disease. The high efficacy of GC to relieve airway obstruction explains their extensive use despite potential deleterious effects. However, much is yet to be uncovered concerning GC use in horses with asthma, including the comparative efficacy of the different drugs, the determination of minimal effective doses and the mechanisms underlying their variable modulation of airway inflammation. The objectives of this structured review were to report and compare the plethora of effects of the various GC used in asthmatic horses with a focus on impact on lung function, airway inflammation, and bronchial remodeling. Adverse effects are also briefly described, with an emphasis on those that have been specifically reported in horses with asthma. Ultimately, we aimed to highlight gaps in the literature and to identify future research areas.

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“…TNF-α es el principal mediador de la respuesta inflamatoria aguda y posee dos receptores (TNF-RI y TNF-RII), los cuales, al ser activados activan varios factores de transcripción, fundamentalmente al NF-kβ, importante para la transcripción de numerosos genes (Caggiano et al, 2013). De hecho, M-CSF, NF-kβ, RANKL y TNF son citoquinas expresadas/secretadas por células inmune que también regulan la osteoclastogénesis (Cuming et al, 2018). Por lo tanto, la vía de señalización RANKL-RANK-NF-kβ es la más importante (Figura 1), y permite la translocación del factor de transcripción NFkβ al núcleo, liberándolo de los complejos IKK que lo retienen en el citoplasma, donde es inactivo (Boyce et al, 2015).…”

Section: Rol De Rankl En La Osteoartitis Y Osteoclastogénesisunclassified

“…La actividad antiinflamatoria de los corticoides resulta de la transcripción/transrepresión sobre al menos 200 genes y el mecanismo es la inducción de lipocortín que inhibe fosfolipasa 2, enzima responsable en la cascada del ácido hialurónico y, finalmente, la producción de mediadores proinflamatorios tromboxanos, leucotrienos y prostaglandinas (Cuming et al, 2018). Por el contrario antiinflamatorios no esteroidales solo inhiben la vía ciclooxigenasa (Bentz, 2015).…”

Section: Uso De Antiinflamatorios En Osteoartritisunclassified

Rol del ligando del factor nuclear kappa Beta (RANKL) en osteoartritis y osteoclastogénesis de equinos fina sangre de carrera. Uso de antiinflamatorios

Negri

Olguín

Pavéz

2021

Rev. investig. vet. Perú

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La osteoartritis (OA) es una de las principales afecciones que incide en el rendimiento de equinos de deporte. El diagnóstico temprano de la enfermedad es relevante en su manejo clínico y terapéutico. La evidencia demuestra que este proceso tiene una clara relación entre osteoclastos y células inmune compartiendo moléculas como citoquinas, receptores, moléculas de señalización, factores de transcripción que se influencian mutuamente donde juegan un rol crucial tanto en la resorción ósea patológica como fisiológica. Se describe el rol del ligando del activador del receptor nuclear-KB (RANKL) como una de las citoquinas más relevantes que inducen osteoclastogénesis.

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Review of glucocorticoid therapy in horses. Part 1: Pharmacology

Cited by 10 publications

References 84 publications

Schiff‐Sherrington syndromein a 7‐year‐old zebra mare (Equus quagga)

Schiff‐Sherrington syndromein a 7‐year‐old zebra mare (Equus quagga)

Glucocorticoid treatment in horses with asthma: A narrative review

Rol del ligando del factor nuclear kappa Beta (RANKL) en osteoartritis y osteoclastogénesis de equinos fina sangre de carrera. Uso de antiinflamatorios

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