Hydrazine-modified starch coated magnetic nanoparticles as an effective pH-responsive nanocarrier for doxorubicin delivery

Zohreh, Nasrin; Hosseini, Seyed Hasan; Pourjavadi, Ali

doi:10.1016/j.jiec.2016.05.029

Cited by 40 publications

(18 citation statements)

References 53 publications

(65 reference statements)

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“…A nanocarrier made of starch, has properties like decreased drug toxicity and side effects, improved drug solubility and stability, tremendous biocompatibility and storage stability, and prolonged residence time by increasing the permeation of loaded drugs . Further, magnetic carrier made from modified starch polysaccharide by PEG and hydrazine coated onto the Fe 3 O 4 magnetic nanoparticles has excellent potential for targeted cancer therapy and MRI imaging . The hydrogel nanocomposite prepared by graft copolymerization of poly (ethylene phthalate) onto starch (starch‐g‐polyester) and Fe 3 O 4 nanoparticles have great applications in drug delivery.…”

Section: Biopolymer Nanoparticlesmentioning

confidence: 99%

“…The hydrogel nanocomposite prepared by graft copolymerization of poly (ethylene phthalate) onto starch (starch‐g‐polyester) and Fe 3 O 4 nanoparticles have great applications in drug delivery. Another study on acetylated starch nanocrystals (ASN) prepared using acetic anhydride, illustrated that DOX‐loaded ASN has higher antitumor activity against HeLa human cervical carcinoma cells than free DOX and DOX‐loaded in starch nanocrystals . Another biopolymeric nanocarrier designed with two anticancer drugs, curcumin and doxorubicin, was synthesized by preparing an inclusion complex of curcumin with amylose biopolymer (prepared as the core of the system) and then the surface was modified with polycaprolactone (PCL) and polycitric acid (PCA) respectively to obtain a water‐soluble, biocompatible, and biodegradable nanomaterial …”

Section: Biopolymer Nanoparticlesmentioning

confidence: 99%

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Biopolymers and Their Composites for Drug Delivery: A Brief Review

Gopi

Amalraj²,

Sukumaran³

et al. 2018

Macromolecular Symposia

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In recent years, excipient development has become a core area of research in pharmaceutical drug delivery because it influences the formulation development and drug delivery process in various ways. Polymeric drug delivery systems have been of great interest for controlled delivery as they show the great advantage in drug delivery systems because of optimized drug loading and releasing property. Then, the side effects of synthetic polymers far exceed that it leads to some difficulties like they impose dose reduction, treatment delay, or the given therapy is not continuous. With this in mind and together with the need for a protective delivery system for drugs, natural polymeric substances such as biopolymers and their composites are the choice of research as excipient because of their low toxicity, biodegradability, stability, and renewable nature. Furthermore, they have a wide variety of structures, different physiological functions and may provide a variety of biomedical applications, owing to their distinctive properties. The present brief review explores the concept of excipient delivery and the recent advances in both the biopolymers and the methods in the pharmaceutical drug delivery systems.

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Section: Biopolymer Nanoparticlesmentioning

confidence: 99%

Section: Biopolymer Nanoparticlesmentioning

confidence: 99%

Biopolymers and Their Composites for Drug Delivery: A Brief Review

Gopi

Amalraj²,

Sukumaran³

et al. 2018

Macromolecular Symposia

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“…13 IONPs have been used to enhance the therapeutic act of anticancer drugs and decrease the side effects that are usually attached to the conventional treatment of cancer. IONPs loaded with different drugs, such as doxorubicin, [14][15][16] paclitaxel, [17][18][19] cisplatin, 20,21 gemcitabine, 22 methotrexate, 23 and docetaxel 24 have been successfully prepared and used for cancer treatment. Dou's group has studied the effect of cytosine arabinoside-magnetic nanoparticles on leukemia stem cells (LSCs).…”

Section: Introductionmentioning

confidence: 99%

Chlorambucil-Iron Oxide Nanoparticles as a Drug Delivery System for Leukemia Cancer Cells

Hussein‐Al‐Ali

Hussein

Saifullah

et al. 2021

IJN

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Introduction: Traditional cancer therapies may have incomplete eradication of cancer or destroy the normal cells. Nanotechnology solves the demerit by a guide in surgical resection of tumors, targeted chemotherapies, selective to cancerous cells, etc. This new technology can reduce the risk to the patient and automatically increased the probability of survival. Toward this goal, novel iron oxide nanoparticles (IONPs) coupled with leukemia anti-cancer drug were prepared and assessed. Methods: The IONPs were prepared by the co-precipitation method using Fe +3 /Fe +2 ratio of 2:1. These IONPs were used as a carrier for chlorambucil (Chloramb), where the IONPs serve as the cores and chitosan (CS) as a polymeric shell to form Chloramb-CS-IONPs. The products were characterized using transmission electron microscopy (TEM), powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) analysis, Fourier transform infrared spectroscopy (FTIR), vibrating sample magnetometry (VSM) analyses, and thermal gravimetric analysis (TGA). Results: The as-prepared IONPs were found to be magnetite (Fe 3 O 4 ) and were coated by the CS polymer/Chloramb drug for the formation of the Chloramb-CS-IONPs. The average size for CS-IONPs and Chloramb-CS-IONPs nanocomposite was found to be 15 nm, with a drug loading of 19% for the letter. The release of the drug from the nanocomposite was found to be of a controlled-release manner with around 89.9% of the drug was released within about 5000 min and governed by the pseudo-second order. The in vitro cytotoxicity studies of CS-IONPs and Chloramb-CS-IONPs nanocomposite were tested on the normal fibroblast cell lines (3T3) and leukemia cancer cell lines (WEHI). Chloramb in Chloramb-CS-IONPs nanocomposite was found to be more efficient compared to its free form. Conclusion:This work shows that Chloramb-CS-IONPs nanocomposite is a promising candidate for magnetically targeted drug delivery for leukemia anti-cancer agents.

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“…Shalviri et al have synthesized pH‐responsive poly(methacrylic acid)‐polysorbate80‐grafted starch (PMMA‐PS 80‐g‐St) nanoparticles for the delivery of doxorubicin (an anticancer drug). Recently, the use of doxorubicin‐loaded hydrazine‐modified starch‐coated magnetite nanoparticles as pH‐responsive drug carriers in the treatment of cancer has been described . Although there were several reports on the synthesis of pH‐ responsive starch nanoparticles, most of these involved grafting of synthetic polymers onto starch molecules, making them unfavorable for biomedical applications.…”

Section: Introductionmentioning

confidence: 99%

pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

et al. 2019

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Starch‐citrate samples with degrees of substitution (DS) ranging from 0.11 to 0.90 are synthesized by a green esterification reaction between citric acid and native sago starch (Metroxylon sagu) in an aqueous medium. Starch‐citrate nanoparticles with mean diameter of 105 nm are subsequently obtained by controlled precipitation through drop‐wise addition of dissolved starch‐citrate solution into excess absolute ethanol. These nanoparticles are observed to exhibit pH‐responsive release profiles within the physiological pH range of 1.2–8.6. The release profile of a model drug (paracetamol) is observed to obey the zero‐order kinetics, with the release mechanism based on the diffusion and swelling model. The cytotoxicity study in HaCaT cell lines (human skin cells) shows that starch‐citrate nanoparticles are non‐toxic and hence are suitable for biomedical applications as pH‐responsive drug carriers.

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Hydrazine-modified starch coated magnetic nanoparticles as an effective pH-responsive nanocarrier for doxorubicin delivery

Cited by 40 publications

References 53 publications

Biopolymers and Their Composites for Drug Delivery: A Brief Review

Biopolymers and Their Composites for Drug Delivery: A Brief Review

Chlorambucil-Iron Oxide Nanoparticles as a Drug Delivery System for Leukemia Cancer Cells

pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

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