pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

Chin, Suk Fun; Romainor, Ain Nadirah; Pang, Suh Cem; Lee, Boon Kiat; Hwang, Siaw San

doi:10.1002/star.201800336

Cited by 16 publications

(14 citation statements)

References 35 publications

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“…Cell assays confirmed that DBS‐NPs exhibited nontoxicity and high biocompatibility. Chin, Romainor, Pang, Lee, and Hwang (2019) prepared citrate‐modified starch with degrees of substitution (DS) ranging from 0.11 to 0.90 and then fabricated nanoparticles with a mean diameter of 105 nm. Cytotoxicity studies of the HaCaT cell line (human skin cells) showed that the nanoparticles were nontoxic and suitable for biomedical applications as pH‐responsive drug carriers.…”

Section: Digestibility and Toxicity Of Starch‐based Nanoparticlesmentioning

confidence: 99%

Starch‐based nanoparticles: Stimuli responsiveness, toxicity, and interactions with food components

Wang

et al. 2020

Comp Rev Food Sci Food Safe

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In recent years, starch‐based nanoparticles have attracted great interest due to their small size, good biocompatibility, and environmental friendliness, as well as their potential applications in foods, drug delivery carriers, and biodegradable edible films. Compared with nonstarch polysaccharides, starch can be enzymatically hydrolyzed into glucose in vivo, so it can be used as an enzyme‐responsive carrier. The recent research progress of starch‐based nanoparticles, including starch nanoparticles, starch nanospheres, starch micelles, starch vesicles, starch nanogels, and starch nanofibers, are reviewed in this paper. The main focus is on their responsiveness, digestibility, toxicity, interactions with other components, and applications. Starch‐based nanoparticles are nontoxic and responsive to pH, temperature, light, and other stimuli. It can interact with proteins, antioxidants, and lipids through electrostatic interactions and hydrogen bonding interactions. Starch‐based nanoparticles have a wide range of applications, including enhancing the mechanical properties of films and gels, stabilizing emulsions, as a fluorescent indicator, a catalyst, and a nanocarrier to control the release of active ingredients and drugs.

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Section: Digestibility and Toxicity Of Starch‐based Nanoparticlesmentioning

confidence: 99%

Starch‐based nanoparticles: Stimuli responsiveness, toxicity, and interactions with food components

Wang

et al. 2020

Comp Rev Food Sci Food Safe

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“…The results showed that these nanoparticles were effective in encapsulating two chemically distinct drugs (indomethacin and ibuprofen sodium) with varying hydrophobicities. They also found that the controlled Ahmad et al (2012) Pea starch Quercetin Evaluation of release kinetics Farrag et al (2018) Sago palm starch Curcumin Bioavailability of curcumin Chin, Mohd, et al (2014) Sago palm starch -pH-responsive drug carriers Tay, Pang, and Chin (2012) Sago palm starch Paracetamol pH-responsive drug carriers Chin, Romainor, Pang, Lee, and Hwang (2019) Sago palm starch Curcumin Bioavailability of curcumin Pang et al (2015) Banana starch Curcumin Oral drug delivery Acevedo-Guevara et al 2018Jackfruit seed starch Ibuprofen Colon-targeted drug delivery Das and Das (2019) Jack bean starch -Nanoparticle disintegrants in drug delivery systems Oladebeye (2020) Cassava (Manihot esculentus) starch Rifampicin Tuberculosis treatment Christianah and Rodrigues (2016) Cassava (variety H-165) Curcumin Cancer therapy Athira and Jyothi (2015) TA B L E 4 (Continued) F I G U R E 2 Comparison between two drug-loading methods used for ciprofloxacin loading on starch nanoparticles (StNPs). (a) Flow chart of the coating method.…”

Section: S Tarch -Ba S Ed Nanoparticle S For Drug Delivery Applic Amentioning

confidence: 99%

Non‐conventional starch nanoparticles for drug delivery applications

Troncoso¹,

Torres²

2020

Med Devices & Sens

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Starch is one of the most abundant biopolymers on earth, next to cellulose and chitin (Tharanathan, 2005). It is one of the most important sources of food for humans, and, at the same time, it is also a renewable resource that could potentially be used in many industrial applications. It is found in plant roots, tubers, stalks and seeds, and is produced by staple crops such as corn, wheat and potato (Buléon, Colonna, Planchot, & Ball, 1998). Most of the starch produced worldwide is derived from corn. Other types of starch such as cassava, potato and wheat starch are also produced in large amounts. Only the starches extracted from these crops are commercially important (Zhu, 2020) and have applications in different areas, such as the food, textile and paper industries (BeMiller & Whistler, 2009; Sjöö & Nilsson, 2018). Starch is synthetized in the chloroplast of plant cells as insoluble granules. These granules are formed by two different polymers: amylose and amylopectin. Amylose is a linear, or slightly branched, polysaccharide of glucose units joined by α-1-4 glycosidic bonds (Dimantov, Greenberg, Kesselman, & Shimoni, 2004). Amylopectin is a branched biopolymer featuring additional α-1-6 glycosidic bonds. The botanical source determines a variety of starch properties such as chemical composition, the amylose/amylopectin relation, molecular weight, molecular structure, the length of the α-glucan chains, the branching degree of amylopectin and the amount of non-carbohydrate impurities, as well as other thermal and rheological properties (Nwokocha, Aviara, Senan, & Williams, 2009). Starch is a cheap and versatile biopolymer that has been used for many biomedical applications, including tissue engineering scaffolds, bone cements, drug delivery systems and stent (Beilvert

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“…The weight of the swollen starch nanoparticles was determined at various time intervals. 13 The swelling ratio was determined based on Equation 2:…”

Section: Swelling Studiesmentioning

confidence: 99%

Synthesis and Characterisation of Piperine-loaded Starch Nanoparticles

Wan-Hong¹,

Chin²,

Pang³

et al. 2020

JPS

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This study aimed to explore the potential application of starch nanoparticles as the nanocarriers for the controlled release of piperine. Starch nanoparticles with mean particle sizes ranging from 50 nm to 200 nm have been synthesised as nanocarriers for encapsulation of piperine. Piperine has been successfully loaded onto starch nanoparticles via the in-situ nanoprecipitation method. The loading capacity of piperine was affected by the synthesis conditions such as types and concentrations of surfactants as well as initial piperine concentrations. Under optimum conditions, starch nanoparticles exhibited a maximum piperine loading capacity of 4.74 mg mg-1. Piperine was observed to release out from starch nanoparticles in a slow and steady manner over a period of 168 h under physiological pH.

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pH‐Responsive Starch‐Citrate Nanoparticles for Controlled Release of Paracetamol

Cited by 16 publications

References 35 publications

Starch‐based nanoparticles: Stimuli responsiveness, toxicity, and interactions with food components

Starch‐based nanoparticles: Stimuli responsiveness, toxicity, and interactions with food components

Non‐conventional starch nanoparticles for drug delivery applications

Synthesis and Characterisation of Piperine-loaded Starch Nanoparticles

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