DOI: 10.1159/000401282
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Hydration and Percutaneous Absorption

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Cited by 14 publications
(12 citation statements)
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“…The two hairless species were chosen because their gross morphology makes them appear similar to human skin. All measurements were made through hydrated skins which is known to enhance permeability [15]. However, most in vitro assessments of clinical efficiency of topical preparations are performed under occlusion, a condition under which similar enhancement of permeability probably occurs.…”
Section: Resultsmentioning
confidence: 99%
“…The two hairless species were chosen because their gross morphology makes them appear similar to human skin. All measurements were made through hydrated skins which is known to enhance permeability [15]. However, most in vitro assessments of clinical efficiency of topical preparations are performed under occlusion, a condition under which similar enhancement of permeability probably occurs.…”
Section: Resultsmentioning
confidence: 99%
“…The rate of increase in permeability of the skin rises rapidly at first, but then the rate diminishes. Still, despite the increase in permeability, the SC remains rather impermeable to water (3).…”
Section: Effects Of Hydrationmentioning
confidence: 99%
“…[25] The water content of the SC in humans is typically 15 to 20% under normal physiological conditions. However, when fully hydrated, such as may occur when the skin is occluded, the highest water content can increase the weight of the SC by up to 400%.…”
Section: Watermentioning
confidence: 99%