Hydration and Percutaneous Absorption

Idson, Bernard

doi:10.1159/000401282

Cited by 15 publications

(13 citation statements)

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“…The two hairless species were chosen because their gross morphology makes them appear similar to human skin. All measurements were made through hydrated skins which is known to enhance permeability [15]. However, most in vitro assessments of clinical efficiency of topical preparations are performed under occlusion, a condition under which similar enhancement of permeability probably occurs.…”

Section: Resultsmentioning

confidence: 99%

Comparison of percutaneous penetration in vitro using clofibric acid esters and amides as novel enhancers in two species: mouse and guinea pig

Michniak

Chapman

1992

Intern J of Cosmetic Sci

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Synopsis A series of clofibric acid esters and amides has been assessed as dermal penetration enhancers towards hydrocortisone-21-acetate, a model drug. In vitro percutaneous absorption experiments on three skin sources (athymic nude mouse, hairless mouse, and hairless guinea pig) showed several compounds to be effective penetration enhancers, the octyl amide providing an approximately 20-fold increase in 24 h diffusion cell receptor drug concentration and 5.7 fold in total steroid skin retention in nude mouse. Azone produced significantly higher (p <0.05) permeation rates than the octyl amide enhancer, but there was a smaller increase in 24 h receptor concentrations, and Azone steroid skin concentrations were significantly less (p < 0.05) than those for the amide. There was no significant difference (p < 0.05) between enhancement in hairless and athymic nude mouse, however, hairless guinea pig skin showed decreased enhancer effectiveness.

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Section: Resultsmentioning

confidence: 99%

Comparison of percutaneous penetration in vitro using clofibric acid esters and amides as novel enhancers in two species: mouse and guinea pig

Michniak

Chapman

1992

Intern J of Cosmetic Sci

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“…The rate of increase in permeability of the skin rises rapidly at first, but then the rate diminishes. Still, despite the increase in permeability, the SC remains rather impermeable to water (3).…”

Section: Effects Of Hydrationmentioning

confidence: 99%

Percutaneous absorption of water in skin: a review

Blattner

Coman

Blickenstaff

et al. 2014

Reviews on Environmental Health

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“…[25] The water content of the SC in humans is typically 15 to 20% under normal physiological conditions. However, when fully hydrated, such as may occur when the skin is occluded, the highest water content can increase the weight of the SC by up to 400%.…”

Section: Watermentioning

confidence: 99%

Percutaneous penetration enhancement in transdermal drug delivery

Singh¹,

Sri²

2010

Asian J Pharm

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T he transdermal route has numerous advantages over the more traditional drug delivery routes. These include high bioavailability, absence of first pass hepatic metabolism, steady drug plasma concentrations, and the fact that therapy is non-invasive. The main obstacle to permeating drug molecules is the outermost layer of the skin, the stratum corneum. Consequently, research into enhancing transdermal drug delivery (TDD) by overcoming this layer, is an area of prime interest. This review article is written to provide a coverage commentary of the recent advancements in TDD enhancement techniques.

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Hydration and Percutaneous Absorption

Cited by 15 publications

References 0 publications

Comparison of percutaneous penetration in vitro using clofibric acid esters and amides as novel enhancers in two species: mouse and guinea pig

Comparison of percutaneous penetration in vitro using clofibric acid esters and amides as novel enhancers in two species: mouse and guinea pig

Percutaneous absorption of water in skin: a review

Percutaneous penetration enhancement in transdermal drug delivery

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