Percutaneous penetration enhancement in transdermal drug delivery

Singh, Inderjeet; Sri, Prasanthi

doi:10.4103/0973-8398.68459

Cited by 8 publications

(8 citation statements)

References 64 publications

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“…The glass transition temperature of some polymers may be decreased after contact with an SCF, by taking the place of CO 2 for a very short time because of an intermolecular interaction between the biodegradable polymers and the dissolved SCF [22]. This results in polymer chains sliding past each other more easily due to the increased free volume [28]. As a result, the polymer will be soft and easily stretched; and those materials whose glass transition is reasonably close to the ambient temperature will exhibit plastic material behavior, like being strong and tough, with good impact resistance.…”

Section: Resultsmentioning

confidence: 99%

New Insights into Acrylic Polymer Precipitation by Supercritical Fluids

et al. 2013

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Nanosystems based on polymers have attracted much attention due to the almost infinite diversity. In the past decades, the application of supercritical fluids for polymeric particle precipitation has been developed as an alternative to conventional processes. Here, precipitation of an acrylic copolymer was attempted by the rapid expansion of supercritical solutions (RESS) and successful by supercritical antisolvent (SAS) processes. In addition, the nanoparticles were characterized with different techniques. The polymer concentration, pressure, temperature, liquid solution flow rate and nozzle diameter effects were also evaluated with regard to particle size and the particle size distribution of this polymer.

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Section: Resultsmentioning

confidence: 99%

New Insights into Acrylic Polymer Precipitation by Supercritical Fluids

et al. 2013

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“…[45] Niosomes are the vesicles devised by using nonionic surfactants. [6,46] Niosomes can deliver targeted drug delivery of drug directly to the specific site where therapeutic effect is needed. [47] It consists of cholesterol to provide rigidity to the vesicles and proper shape.…”

Section: Niosomesmentioning

confidence: 99%

Untitled

Sheikh¹

2016

AJP

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Nowadays conventional dosage forms of drugs are rapidly being replaced by the new and the novel drug delivery systems. Among, these the controlled release/sustained release dosage forms have become extremely popular in modern therapeutics. In the last few years, sustained release injections have developed. At targeted site, these injections showed the prolong effect of drug. Decrease in side effects, lesser frequency of dose, maximum doseefficacy relationship, and improved patient compliance are the benefits received by controlled release of drugs. To the systemic circulation, parenteral drug delivery can achieve easy access with rapid drug absorption. It is always advantageous to achieve the systemic drug levels within the therapeutically effective concentration range of drug for obtaining the better treatment. With the arrival of novel carriers, the research in parenteral sustained release technologies has received huge boost up. So, many injectable sustained release products have received regulatory approval and launched in the pharmaceutical market. In the present review, efforts were put forth on the rationale and most recent progress done in the development and formulation of parenteral controlled release systems. The review focused on the current long-acting injectable preparations with special attention to marketed products.

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“…Cross and Roberts showed that solute in the upper layer of the skin following iontophoresis was comparable in anaesthetized rats and sacrificed rats. It can thus be presumed that the blood did not affect the penetration through the epidermis since the latter has no blood supply [ 17 , 57 ]. Condition of skin also affects the penetrating properties of permeant.…”

Section: Iontophoretic Research and Drug Deliverymentioning

confidence: 99%

“…Various technologies other than iontophoresis such as ultrasound, chemical enhancers, and electroporation have been used for enhancing transdermal drug transport. The following combinational iontophoresis techniques have been used for TDDS [ 17 ]:…”

Section: Introductionmentioning

confidence: 99%

Iontophoresis: A Potential Emergence of a Transdermal Drug Delivery System

Dhote¹

2012

Sci. Pharm.

128

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The delivery of drugs into systemic circulation via skin has generated much attention during the last decade. Transdermal therapeutic systems propound controlled release of active ingredients through the skin and into the systemic circulation in a predictive manner. Drugs administered through these systems escape first-pass metabolism and maintain a steady state scenario similar to a continuous intravenous infusion for up to several days. However, the excellent impervious nature of the skin offers the greatest challenge for successful delivery of drug molecules by utilizing the concepts of iontophoresis. The present review deals with the principles and the recent innovations in the field of iontophoretic drug delivery system together with factors affecting the system. This delivery system utilizes electric current as a driving force for permeation of ionic and non-ionic medications. The rationale behind using this technique is to reversibly alter the barrier properties of skin, which could possibly improve the penetration of drugs such as proteins, peptides and other macromolecules to increase the systemic delivery of high molecular weight compounds with controlled input kinetics and minimum inter-subject variability. Although iontophoresis seems to be an ideal candidate to overcome the limitations associated with the delivery of ionic drugs, further extrapolation of this technique is imperative for translational utility and mass human application.

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Percutaneous penetration enhancement in transdermal drug delivery

Cited by 8 publications

References 64 publications

New Insights into Acrylic Polymer Precipitation by Supercritical Fluids

New Insights into Acrylic Polymer Precipitation by Supercritical Fluids

Untitled

Iontophoresis: A Potential Emergence of a Transdermal Drug Delivery System

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