Percutaneous absorption of water in skin: a review

Blattner, Collin M.; Coman, Garett; Blickenstaff, Nicholas; Maibach, Howard I.

doi:10.1515/reveh-2014-0045

Cited by 18 publications

(12 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An ideal system for potential use in chronic diseases with a slow healing process, such as wounds or psoriasis, should exhibit sustained drug release in order to allow permeation through the skin [20,45]. In this regard, the alginate membranes developed in our study possess polymeric networks as a structure, as well as the curcumin encapsulated in PCL nanoparticles dispersed within these networks.…”

Section: Resultsmentioning

confidence: 99%

“…Water affects the absorption rates of different substances through the stratum corneum, which is in a constant state of partial hydration under normal conditions. Thus, when immersed in water, dead keratinocytes quickly absorb it, resulting in the pruning effect of the skin [45]. Furthermore, water in contact with skin creates a flow gradient toward the skin’s inner layers, since the inside of the stratum corneum is more hydrated than the surface [46].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications

et al. 2019

View full text Add to dashboard Cite

Non-biodegradable materials with a low swelling capacity and which are opaque and occlusive are the main problems associated with the clinical performance of some commercially available wound dressings. In this work, a novel biodegradable wound dressing was developed by means of alginate membrane and polycaprolactone nanoparticles loaded with curcumin for potential use in wound healing. Curcumin was employed as a model drug due to its important properties in wound healing, including antimicrobial, antifungal, and anti-inflammatory effects. To determine the potential use of wound dressing, in vitro, ex vivo, and in vivo studies were carried out. The novel membrane exhibited the diverse functional characteristics required to perform as a substitute for synthetic skin, such as a high capacity for swelling and adherence to the skin, evidence of pores to regulate the loss of transepidermal water, transparency for monitoring the wound, and drug-controlled release by the incorporation of nanoparticles. The incorporation of the nanocarriers aids the drug in permeating into different skin layers, solving the solubility problems of curcumin. The clinical application of this system would cover extensive areas of mixed first- and second-degree wounds, without the need for removal, thus decreasing the patient’s discomfort and the risk of altering the formation of the new epithelium.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications

et al. 2019

View full text Add to dashboard Cite

show abstract

“…The TEWL is widely used in skin integrity tests with a large historical dataset [ 24 – 28 ]. Many studies have suggested that high TEWL is associated with various skin diseases, including atopic dermatitis, psoriasis, contact dermatitis, and ichthyosis [ 29 – 32 ]. Thus, TEWL is thought to be a useful parameter that characterizes skin barrier function in man.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Impact of Mechanical Damage on Full-Thickness Porcine and Human Skin Using anIn VitroApproach

Dabboue

Builles

Frouin

et al. 2015

BioMed Research International

View full text Add to dashboard Cite

For most xenobiotics, the rates of percutaneous absorption are limited by diffusion through the horny layer of skin. However, percutaneous absorption of chemicals may seriously increase when the skin is damaged. The aim of this work was to develop an in vitro representative model of mechanically damaged skins. The epidermal barrier was examined following exposure to a razor, a rotating brush, and a microneedle system in comparison to tape-stripping which acted as a reference. Excised full-thickness skins were mounted on a diffusion chamber in order to evaluate the effect of injuries and to mimic physiological conditions. The transepidermal water loss (TEWL) was greatly increased when the barrier function was compromised. Measurements were made for all the damaged biopsies and observed histologically by microscopy. On human and porcine skins, the tape-stripping application (0 to 40 times) showed a proportional increase in TEWL which highlights the destruction of the stratum corneum. Similar results were obtained for all cosmetic instruments. This is reflected in our study by the nonsignificant difference of the mean TEWL scores between 30 strips and mechanical damage. For a specific appreciation, damaged skins were then selected to qualitatively evaluate the absorption of a chlorogenic acid solution using fluorescence microscopy.

show abstract

“…Linolenic acid has a potent 5-alpha-reductase inhibitory effect and antiinflammatory effect, 6 linoleic acid is known to down-regulate neutrophil oxygen metabolism and phagocytosis, 7 and lecithin plays an important role in maintaining the steady state of the skin by reducing water loss from the stratum corneum and decreasing the lipofuscin content in keratinocytes. 8 In this case series, all four patients appeared effective reduction in inflammatory and non-inflammatory lesions of the face, excellent tolerability with no side effects. F I G U R E 3 Case 3: photographs of a 29-year-old female subject A, before and B, after 8 weeks of treatment with acne cream on the face F I G U R E 4 Case 4: photographs of a 21-year-old female subject A, before and B, after 8 weeks of treatment with acne cream on the face…”

Section: Casementioning

confidence: 56%

A case series evaluating the impact of a combination treatment for acne vulgaris containing linoleic acid, linolenic acid, and lecithin

Cheng

Zeng

Wang

et al. 2020

Dermatologic Therapy

View full text Add to dashboard Cite

Dear Editor, Acne vulgaris is a chronic inflammatory skin condition affecting the face, the most significant area in terms of cosmetic appearance. 1 Clinical treatment approaches primarily include oral antibiotics or isotretinoin, topical tretinoin, and photodynamic therapy. 2 However, there is an urgent need to optimize acne treatment due to the range of side effects associated with current approaches, such as dryness, rebound, desquamation, and drug resistance. 3 In this article, we present a case series involving four subjects selected from a larger ongoing study which aims to determine the effectiveness of treatment with a topical cream containing 20% linolenic acid, 60% linoleic acid, and 2% lecithin.

show abstract

Percutaneous absorption of water in skin: a review

Cited by 18 publications

References 31 publications

Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications

Development and Evaluation of Alginate Membranes with Curcumin-Loaded Nanoparticles for Potential Wound-Healing Applications

Assessing the Impact of Mechanical Damage on Full-Thickness Porcine and Human Skin Using anIn VitroApproach

A case series evaluating the impact of a combination treatment for acne vulgaris containing linoleic acid, linolenic acid, and lecithin

Contact Info

Product

Resources

About