Hybrid Zinc Oxide Nanoparticles for Biophotonics

John, Sween; Marpu, Sreekar B.; Li, Jianyou; Omary, Mohammad A.; Hu, Zhibing; Fujita, Yasuhisha; Neogi, Arup

doi:10.1166/jnn.2010.2044

Cited by 37 publications

(16 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This NP may also be swallowed directly through food bundling or medication delivery (14,15). Emamifar et al demonstrated that zinc (Zn) ions considerably migrate in low-density polyethylene (LDPE) nanocomposite packaging (16).…”

Section: Introductionmentioning

confidence: 99%

Nephrotoxic effects of low-dose zinc oxide nanoparticles in rats

Khorsandi¹,

Moghadam²,

Jozi³

2018

J Nephropathol

View full text Add to dashboard Cite

Background: The use of zinc oxide nanoparticles (ZNPs) in various products such as biosensors, sunscreens and nourishment added substances is increasing. Objectives: In the present work the impacts of ZNP on kidney of rats was explored. Materials and Methods: In this experimental study male Wistar rats were used. Trial groups received 5, 50 and 300 mg/kg ZNP (ZNP-1 to ZNP-3) for 2 weeks. Control group received only normal saline. blood urea nitrogen (BUN), creatinine (Cr) and uric acid were considered as biomarkers to indicate nephrotoxicity. To evaluate the oxidative stress in the kidney, malondialdehyde (MDA), superoxide dismutase (SOD), and glutathione peroxidase (GPx) enzymes activity were measured. Histopathological and apoptotic cell death was also evaluated in renal tissues.Results: Blood density of zinc (Zn) was significantly increased in the low dose-treated rats. Concentration of Zn in the renal tissue was significantly increased in the high dose treated rats. Weight of kidney was significantly elevated in both ZNP-1 and ZNP-2 groups. ZNP resulted in a significant increment in MDA content in the low measurements and a critical reduction in the activity of the SOD and GPx enzymes. Exposure of ZNP at low dose induced a significant elevation in blood concentration of BUN, Cr and uric acid. Treatment with low dose of ZNP caused a significant increase in histological changes and apoptotic index. ZNP at the high dose induced poor nephrotoxicity. Conclusion: In conclusion, ZNP has dose-dependent nephrotoxic effects on rats and lower doses have more toxic action. ABSTRACT Implication for health policy/practice/research/medical education:In this study we demonstrated that zinc oxide nanoparticles (ZNPs) dose-dependently induced nephrotoxicity by elevation blood biochemical markers and generation of stress oxidative. ZNPs dose-dependently induced structural changes and increased apoptosis in renal tissue. Lower doses of this nanoparticle have more nephrotoxicity effects. The results of this study highlighted the requirement for alert during the utilization of ZNPs to prevent health impacts. Please cite this paper as: Khorsandi L, Heidari-Moghadam A, Jozi Z. Nephrotoxic effects of low-dose zinc oxide nanoparticles in rats. J Nephropathol. 2018;7(3):158-165.

show abstract

Section: Introductionmentioning

confidence: 99%

Nephrotoxic effects of low-dose zinc oxide nanoparticles in rats

Khorsandi¹,

Moghadam²,

Jozi³

2018

J Nephropathol

View full text Add to dashboard Cite

show abstract

“…ZnO NPs are being used in the food industry as additives and in packaging due to their antimicrobial properties (Gerloff et al 2009;Jin et al 2009). They are also being explored for their potential use as fungicides in agriculture (He at al., 2010] and as anticancer drugs and imaging in biomedical applications (Rasmussen et al 2010;John et al 2010). …”

Section: Discussionmentioning

confidence: 99%

Biochemical and histopathological ultrastructural changes caused by ZnO nanoparticles in mice

Ansari

Khan

et al. 2015

Toxicological & Environmental Chemistry

View full text Add to dashboard Cite

Five week-old mice were divided into a vehicle control group, and groups exposed to ZnO nanoparticles at low (0.5 g/kg), middle (1 g/kg), high (3g/kg) and exceptionally high-dose (5 g/kg). After the 1 st , 2 nd , 3 rd and 4 th weeks of exposure, blood biochemistry, histopathology, and electron microscopic ultrastructural changes in liver, kidney and spleen were investigated. Increased alkaline phosphatase activities were observed in all treated mice being statistically significant at higher dose. No changes were observed in the serum glutamic pyruvic transaminase, serum glutamic oxaloacetic transaminase, creatinine, blood urea nitrogen and ,lipid levels. During the 1 st and 2 nd week of treatment, effects on the cytoarchitecture of liver, kidney and spleen were not perceived while during the 3 rd and 4 th week of treatment sporadic mild effects were seen. Ultrastructural electron microscopic changes in liver, kidney and spleen were not observed for the low-dose group onthe 1 st , 2 nd , 3 rd and 4 th week, suggesting that exposure to ZnO nanoparticles at low dose is safe. Long term (i.e, more than 28 days) exposure to the exceptionally high-dose resulted in sporadic changes in nuclear chromatin condensation, irregular nuclear membrane, polymorphic mitochondria, mitochondrial swelling and vacuolation. ZnO nanoparticles could be well tolerated and no death occurred in any group of treated mice.

show abstract

“…ZnO NPs are added to various materials and products, for example, plastics, glass, ceramics, rubber, cement, paints, lubricants, ointments, sealants, adhesives, batteries, pigments, ferrites, and fire retardants. Furthermore, ZnO nanometals have ultraviolet (UV)-shielding, deodorizing impacts, antibacterial properties, impact and heat and UV light resistance, which could afford a great potential for its widespread use in many fields including cosmetics and sunscreens [6], fungicides in agriculture [9], food additives and additives in packing [7,8], and biomedical uses such as anticancer drugs [10,11]. Nanoparticles are highly reactive due to their small size as well as high surface area.…”

Section: Introductionmentioning

confidence: 99%

The Impact of Zinc Oxide Nanoparticle on LH, FSH, and Testosterone Hormones in Mature Male NMRI Rats

Mozaffari

Parivar

Roodbari

et al. 2020

JPRI

View full text Add to dashboard Cite

Nanoparticles are widely applied in all aspects of modern life because of their unique features such as small size and high surface area. Several types of research have been carried out to discover the feasible detrimental impacts of Nano-particles on human reproduction. The purpose of this study was to examine the impact of zinc oxide nanoparticles in mature male rats through examining LH, FSH, and testosterone sex hormones. Therefore, 30 Naked Mole-Rat Initiative (NMRI) rats were divided into 5 groups. Different doses of zinc oxide nanoparticles (250, 500 and 700 mg.kg-1) were intra peritoneally injected to animals only once. Then, the serum level of luteinizing hormone (LH), Follicle Stimulating Hormone (FSH), and testosterone hormones were measured using Enzyme-Linked Immunosorbent Assay (ELISA) method after 21 days. The results were analyzed by ANOVA and Tukey tests. The results indicated that zinc oxide nanoparticles doses caused a significant increase in FSH and testosterone level of blood (Respectively) in 250 and 700mg.kg-1 in comparison with the control group. Moreover, this research illustrated that zinc oxide nanoparticle can cause a dose-related increase in Testosterone and FSH hormones levels while causing no significant change in LH hormone level.

show abstract

Hybrid Zinc Oxide Nanoparticles for Biophotonics

Cited by 37 publications

References 15 publications

Nephrotoxic effects of low-dose zinc oxide nanoparticles in rats

Nephrotoxic effects of low-dose zinc oxide nanoparticles in rats

Biochemical and histopathological ultrastructural changes caused by ZnO nanoparticles in mice

The Impact of Zinc Oxide Nanoparticle on LH, FSH, and Testosterone Hormones in Mature Male NMRI Rats

Contact Info

Product

Resources

About