To study the bonding shear performance of the casting interface in the functionally gradient concrete (FGC), a multiphase mesoscopic finite element modeling method was proposed to simulate a sandwich FGC specimen with the normal weight concrete (NWC) cast on the hardened ceramsite lightweight aggregate concrete (LWAC) layer. Four kinds of phases are considered during modeling: coarse aggregates, mortar substrate, interface transition zone (ITZ) between the mortar and coarse aggregates, and the casting interface transition zone (C-ITZ). Each phase in the model is endowed with the respective material property based on the constitutive damage plastic model (CDP). The structural characteristics of the C-ITZ that are related to the casting construction of the FGC are fully considered in the proposed modeling method. Based on the verification by corresponding experiments, the internal damage is developed, and the failure mechanisms of the FGC model are effectively reflected by the simulation. For the designed FGC specimen corresponding to the experiment, the weak position is proved to be located on the C-ITZ. The damage development and damage characteristics of the given FGC specimen are more related to the casting interval time of the FGC.