Hybrid chitosan–Pluronic F-127 films with BaTiO3:Co nanoparticles: Synthesis and properties

Fuentes, S.; Dubo, J.; Barraza, N.; González, Rodrigo; Veloso, Eugenio E.

doi:10.1016/j.jmmm.2014.10.050

Cited by 7 publications

(4 citation statements)

References 25 publications

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“…Nowadays, BaTiO 3 NPs can be produced through several synthetic routes such as co-precipitation, [140][141][142][143][144][145][146] sol-gel methods, [89,[147][148][149][150][151][152] hydrothermal, [146,150,[153][154][155][156][157][158][159] and solvothermal [160] synthesis, and high-energy milling [144,[161][162][163][164][165][166][167] (Figure 4).…”

Section: Different Synthesis Methods Of Batio 3 Nanoparticlesmentioning

confidence: 99%

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A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

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et al. 2022

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Stimulation of cells with electrical cues is an imperative approach to interact with biological systems and has been exploited in clinical practices over a wide range of pathological ailments. This bioelectric interface has been extensively explored with the help of piezoelectric materials, leading to remarkable advancement in the past two decades. Among other members of this fraternity, colloidal perovskite barium titanate (BaTiO3) has gained substantial interest due to its noteworthy properties which includes high dielectric constant and excellent ferroelectric properties along with acceptable biocompatibility. Significant progression is witnessed for BaTiO3 nanoparticles (BaTiO3 NPs) as potent candidates for biomedical applications and in wearable bioelectronics, making them a promising personal healthcare platform. The current review highlights the nanostructured piezoelectric bio interface of BaTiO3 NPs in applications comprising drug delivery, tissue engineering, bioimaging, bioelectronics, and wearable devices. Particular attention has been dedicated toward the fabrication routes of BaTiO3 NPs along with different approaches for its surface modifications. This review offers a comprehensive discussion on the utility of BaTiO3 NPs as active devices rather than passive structural unit behaving as carriers for biomolecules. The employment of BaTiO3 NPs presents new scenarios and opportunity in the vast field of nanomedicines for biomedical applications.

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Section: Different Synthesis Methods Of Batio 3 Nanoparticlesmentioning

confidence: 99%

“…Nowadays, BaTiO 3 NPs can be produced through several synthetic routes such as co‐precipitation, [ 140–146 ] sol–gel methods, [ 89,147–152 ] hydrothermal, [ 146,150,153–159 ] and solvothermal [ 160 ] synthesis, and high‐energy milling [ 144,161–167 ] ( Figure ).…”

Section: Synthesis and Functionalization Of Batio3 Nanoparticlesmentioning

confidence: 99%

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Sood

Desseigne

Dev

et al. 2022

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“…Pluronic-involved formation of superparamagnetic Fe 3 O 4 NPs can yield particles with better aqueousdispersity and lower toxicity. [60][61][62] Indeed, Pluronic have been extensively used for drug delivery due to their thermo-sensitive and amphiphilic properties. The dispersion of Fe 3 O 4 -MSA NPs into the Pluronic matrix combines the magnetic features of these NPs with the biocompatibility and amphiphilicity of F127, enhancing the dispersion of Fe 3 O 4 -MSA NPs in aqueous media and polar solvents and leading to a promising nanomaterial for biomedical eld.…”

Section: Characterization Of Fe 3 O 4 -Msa-f127 Npsmentioning

confidence: 99%

Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications

et al. 2017

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“…P407 gels have an inherent tendency to improve the solubilization of hydrophobic drugs due to amphiphilic nature of polymer. Moreover, additives of different functionalities may be incorporated in gels without compromising their gelation ability [ 13 , 14 ]. Tanriverdi and Ozer reported the highest amount of drug accumulation in nail using poloxamer gel as compared to chitosan and carbopol gel [ 15 ].…”

Section: Introductionmentioning

confidence: 99%

Poloxamer 407 Based Gel Formulations for Transungual Delivery of Hydrophobic Drugs: Selection and Optimization of Potential Additives

et al. 2021

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The current study aimed to develop poloxamer 407 (P407) gel for transungual delivery of antifungal hydrophobic drugs with sufficient gel strength and drug loading. Gel strength and drug loading of P407 gel was improved by use of functional additives. Ungual penetration enhancers (PEs) were screened based on the hydration enhancement effect to select optimum nail penetration enhancer. Face-centered central composite design (FCCCD) was used to observe the effect of the selected penetration enhancer (thioglycolic acid (TGA)) and cosolvent (ethanol) on gelation behavior to develop formulation with enough loading of hydrophobic drug, i.e., terbinafine HCl (TBN), and its permeation across the nail plate without compromising on gel strength. It was observed that increasing concentration of P407 and TGA significantly reduced gelation temperature and enhanced the gel strength of P407 gel and can be used to improve P407 gel strength. Under the scanning electron microscope, the significant effect of TGA as an ungual penetration enhancer was observed on the morphology of the nail plate. Optimized P407 gel (P407: 27.32% w/w, ethanol: 3.18% w/w and TGA: 4.72% w/w), prepared with modified cold method showed a gelation temperature of 8.7 ± 0.16 °C, gel strength of 122 ± 7.5 s and drug loading of 1.2% w/w, which was four times more than the drug loading in the gels prepared with conventional cold method. Rheological behavior was pseudoplastic with 47.75 ± 3.48% of gel erosion after 12 washings and 67.21 ± 2.16% of drug release after 12 h. A cumulative amount of TBN permeated from P407 gel with and without PE after 24 h was 27.30 ± 4.18 and 16.69 ± 2.31 µg/cm2, respectively. Thioglycolic acid can be used as a nail penetration enhancer without the chemical modification or addition of extra additives while retaining the gel strength. Water miscible cosolvents with moderate evaporability such as ethanol, can be incorporated to P407 gel by minor modification in method of preparation to load the required dose of hydrophobic drugs. Developed P407 gel formulation with sufficient gel strength and drug loading will be a promising carrier for transungual delivery of hydrophobic antifungal agents.

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Hybrid chitosan–Pluronic F-127 films with BaTiO3:Co nanoparticles: Synthesis and properties

Cited by 7 publications

References 25 publications

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

A Comprehensive Review on Barium Titanate Nanoparticles as a Persuasive Piezoelectric Material for Biomedical Applications: Prospects and Challenges

Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications

Poloxamer 407 Based Gel Formulations for Transungual Delivery of Hydrophobic Drugs: Selection and Optimization of Potential Additives

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