Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications

Gonçalves, Luís Carlos Oliveira; Seabra, Amedea B.; Pelegrino, Milena T.; Araújo, Daniele Ribeiro de; Bernardes, Juliana S.; Haddad, Paula S.

doi:10.1039/c6ra28633j

Cited by 83 publications

(39 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The O 1s deconvoluted XPS spectra shows two types of oxygen present in the IONPs (Figure B). This confirms that iron oxide is in form of Fe 3 O 4 …”

Section: Resultssupporting

confidence: 74%

Environmentally Friendly Inorganic Magnetic Sulfide Nanoparticles for Efficient Adsorption‐Based Mercury Remediation from Aqueous Solution

et al. 2018

View full text Add to dashboard Cite

Inorganic sulphidenanoparticles (NPs) were prepared by wrapping the magnetic iron oxide NPs with thin shell (5 nm) of zinc sulphide. The as prepared NPs show maximum mercury removal capacity of 98-99% under ambient conditions from tap, ground and polluted river water without any pre-treatment. The magnetic nanoparticlesinteract with toxic mercuric ions predominately by adsorption phenomenon and shows excellent thermodynamic parameters fitted with Langmuir and van'thoff isotherms. The as prepared magnetic NPshave high selectivity for mercury, practical utility and can be scaled up at pilot scale.

show abstract

“…The O 1s deconvoluted XPS spectra shows two types of oxygen present in the IONPs (Figure B). This confirms that iron oxide is in form of Fe 3 O 4 …”

Section: Resultssupporting

confidence: 74%

Environmentally Friendly Inorganic Magnetic Sulfide Nanoparticles for Efficient Adsorption‐Based Mercury Remediation from Aqueous Solution

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Permeation study carried using a Strat-M™ membrane demonstrated that the iron will not permeate from the nanoparticle dispersed in Pluronic. [111] Topical delivery of niclosamide (niclo) using octenylsuccinate hydroxypropyl phytoglycogen (OHPP) as a solubilizing agent.…”

Section: Study Important Findings Referencesmentioning

confidence: 99%

Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities

et al. 2020

View full text Add to dashboard Cite

The transdermal route of drugs has received increased attention in recent years due to numerous advantages over the oral and injectable routes, such as avoidance of the hepatic metabolism, protection of drugs from the gastrointestinal tract, sustained drug delivery, and good patient compliance. The assessment of ex vivo permeation during the pharmaceutical development process helps in understanding the product quality and performance of a transdermal delivery system. Generally, excised human skin relevant to the application site or animal skin is recommended for ex vivo permeation studies. However, the limited availability of the human skin and ethical issues surrounding the use of animal skin rendered these models less attractive in the permeation study. In the last three decades, enormous efforts have been put into developing artificial membranes and 3D cultured human skin models as surrogates to the human skin. This manuscript provides an insight on the European Medicines Agency (EMA) guidelines for permeation studies and the parameters affected when using Franz diffusion cells in the permeation study. The need and possibilities for skin alternatives, such as artificially cultured human skin models, parallel artificial membrane permeability assays (PAMPA), and artificial membranes for penetration and permeation studies, are comprehensively discussed.

show abstract

“…The first one is, the presence of another diamagnetic layer besides the chitosan; and the second one is the contributions from intrinsic particles, shape and stress anisotropies due to different ligands along with interparticle interactions (dipolar), which can provide a difference in the energy barrier. Nanoparticles are strongly attracted by a magnetic field, and when this field is removed, their magnetization is reduced close to zero, without residual magnetization [54][55][56]. Figure 6a shows SEM images for nanoparticles containing IBU, in which the light green dots corresponds to iron (Fe, from magnetite core), dark green corresponds to oxygen (O, from magnetite, chitosan and ibuprofen) and red dots correspond to carbon (C, from chitosan and ibuprofen) atoms.…”

Section: Magnetic Measurementsmentioning

confidence: 99%

Biocompatible superparamagnetic nanoparticles with ibuprofen as potential drug carriers

et al. 2020

Self Cite

View full text Add to dashboard Cite

This article describes the synthesis, characterization, in vitro cytotoxic and genotoxicity evaluation of chitosan-iron oxide nanoparticles (Fe 3 O 4 -CS) as vehicles for ibuprofen (IBU) molecule. Magnetite (Fe 3 O 4 ) nanoparticles were synthesized by co-precipitation of iron salts and coated with chitosan, leading to the formation of Fe 3 O 4 -CS hybrid nanoparticles, and then IBU was adsorbed on the surface of the modified nanoparticles. The physicochemical, morphological, and magnetic properties of the nanoparticles were determined by X-ray powder diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy and SQUID magnetic measurements. The nanoparticles have shown stability in aqueous medium presenting an average hydrodynamic size of 36 ± 9 nm for Fe 3 O 4 -CS, and 132 ± 1 nm for Fe 3 O 4 -CS-IBU. The cytotoxicity of nanoparticles using the cell viability of the blood mononuclear cell fraction and the analysis of gene expression of the repair genes hMSH2, hMSH6 and NF-kB were performed to evaluate their applicability as drug carriers. The results showed that Fe 3 O 4 -CS nanoparticles are suitable candidates as magnetic vehicles for ibuprofen in biomedical applications. Graphic abstract

show abstract

Superparamagnetic iron oxide nanoparticles dispersed in Pluronic F127 hydrogel: potential uses in topical applications

Abstract: The present study is focused on the synthesis and characterization of nitric oxide (NO)-releasing superparamagnetic iron oxide nanoparticles, and their incorporation in Pluronic F127 hydrogel with great potential for topical applications.

Cited by 83 publications

References 63 publications

Environmentally Friendly Inorganic Magnetic Sulfide Nanoparticles for Efficient Adsorption‐Based Mercury Remediation from Aqueous Solution

Environmentally Friendly Inorganic Magnetic Sulfide Nanoparticles for Efficient Adsorption‐Based Mercury Remediation from Aqueous Solution

Alternatives to Biological Skin in Permeation Studies: Current Trends and Possibilities

Biocompatible superparamagnetic nanoparticles with ibuprofen as potential drug carriers

Contact Info

Product

Resources

About