Hyaluronic acid nanofiber wound dressing—production, characterization, and <i>in vivo</i> behavior

Uppal, Rohit; Ramaswamy, Gita; Arnold, Carolyn E.; Goodband, Robert D.; Wang, Y.

doi:10.1002/jbm.b.31776

Cited by 168 publications

(87 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…CF wound dressings, as well as NF wound dressings, showed a positive influence on wound healing, as determined by histological analysis. Hyaluronic acid nanofibers have been shown to be effective in promoting wound healing of full-thickness excisional wounds in pigs, and chitosan-poly(vinyl alcohol) nanofibers only showed a positive influence on wound healing when used in combination with R-Spondin I, a novel growth factor (52,53). Curcumin-loaded poly(ε-caprolactone) (PCL) also showed improved wound healing from day 6 compared to plain PCL over a 10-day period in a diabetic murine model (54).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a Nisin-Eluting Nanofiber Scaffold To Treat Staphylococcus aureus-Induced Skin Infections in Mice

Heunis

Smith

Dicks

2013

Antimicrob Agents Chemother

130

View full text Add to dashboard Cite

Staphylococcus aureus is a virulent pathogen and a major causative agent of superficial and invasive skin and soft tissue infections (SSSTIs). Antibiotic resistance in S. aureus, among other bacterial pathogens, has rapidly increased, and this is placing an enormous burden on the health care sector and has serious implications for infected individuals, especially immunocompromised patients. Alternative treatments thus need to be explored to continue to successfully treat infections caused by S. aureus, including antibiotic-resistant strains of S. aureus. In this study, an antimicrobial nanofiber wound dressing was generated by electrospinning nisin (Nisaplin) into poly(ethylene oxide) and poly(D,L-lactide) (50:50) blend nanofibers. Active nisin diffused from the nanofiber wound dressings for at least 4 days in vitro, as shown by consecutive transfers onto plates seeded with strains of methicillin-resistant S. aureus (MRSA). The nisin-containing nanofiber wound dressings significantly reduced S. aureus Xen 36 bioluminescence in vivo and viable cell numbers in a murine excisional skin infection model. The bacterial burden of wounds treated with nisin-containing nanofiber wound dressings was 4.3 ؋ 10 2 CFU/wound, whereas wounds treated with control nanofiber wound dressings had 2.2 ؋ 10 7 CFU/wound on the last day of the trial (day 7). Furthermore, the wound dressings stimulated wound closure of excisional wounds, and no adverse effects were observed by histological analysis. Nisin-containing nanofiber wound dressings have the potential to treat S. aureus skin infections and to potentially accelerate wound healing of excisional wounds.

show abstract

Section: Discussionmentioning

confidence: 99%

Evaluation of a Nisin-Eluting Nanofiber Scaffold To Treat Staphylococcus aureus-Induced Skin Infections in Mice

Heunis

Smith

Dicks

2013

Antimicrob Agents Chemother

130

View full text Add to dashboard Cite

show abstract

“…The HA is proved to be beneficial in wound healing applications since it plays major role in facilitating keratinocyte migration and proliferation, activating and moderating the inflammatory response, and reducing scar formation. A preclinical study was conducted to compare healing of wounds covered by an adhesive bandage, a sterilized solid HA, a gauze with Vaseline, an antibiotic dressing, and a sterilized HA nanofiber wound dressing on crossbred pigs as an experimental model [32]. The study results showed that the sterilized HA nanofiber wound dressing exhibited better healing efficiency than adhesive bandage, sterilized solid HA, and gauze with Vaseline dressing, but it was not statistically better than the antibiotic dressing.…”

Section: Natural Polymer Nanofibers As Wound Healing Scaffoldsmentioning

confidence: 99%

Electrospun nanofibrous materials for wound healing applications

Balusamy

Anitha

Uyar

2017

Electrospun Materials for Tissue Engineering and Biomedical Applications

View full text Add to dashboard Cite

“…A variety of polymer-based nanofibers have been applied as wound dressings, including polyvinylalcohol [143], chitosan [130], gelatine [144], hyaluronic acid [145], collagen and collagen-based composites [146,147], polyethersulfone [148], and polyurethane/polyurethane nanocomposites [149,150]. Polyethersulfone (PES), a synthetic and biocompatible polymer, was electrospun into nanofibers and applied as an epidermal wound dressing, which proved to be effective in improving the skin healing [148].…”

Section: Polymer-based Nanofibers For Wound Dressingmentioning

confidence: 99%

Multifunctional Nanofibers towards Active Biomedical Therapeutics

et al. 2015

View full text Add to dashboard Cite

One-dimensional (1-D) nanostructures have attracted enormous research interest due to their unique physicochemical properties and wide application potential. These 1-D nanofibers are being increasingly applied to biomedical fields owing to their high surface area-to-volume ratio, high porosity, and the ease of tuning their structures, functionalities, and properties. Many biomedical nanofiber reviews have focused on tissue engineering and drug delivery applications but have very rarely discussed their use as wound dressings. However, nanofibers have enormous potential as wound dressings and other clinical applications that could have wide impacts on the treatment of wounds. Herein, the authors review the main fabrication methods of nanofibers as well as requirements, strategies, and recent applications of nanofibers, and provide perspectives of the challenges and opportunities that face multifunctional nanofibers for active therapeutic applications.

show abstract

Hyaluronic acid nanofiber wound dressing—production, characterization, and in vivo behavior

Cited by 168 publications

References 23 publications

Evaluation of a Nisin-Eluting Nanofiber Scaffold To Treat Staphylococcus aureus-Induced Skin Infections in Mice

Evaluation of a Nisin-Eluting Nanofiber Scaffold To Treat Staphylococcus aureus-Induced Skin Infections in Mice

Electrospun nanofibrous materials for wound healing applications

Multifunctional Nanofibers towards Active Biomedical Therapeutics

Contact Info

Product

Resources

About