Hyaluronic acid mediated biomineralization of multifunctional ceria nanocomposites as ROS scavengers and tumor photodynamic therapy agents

Abstract

A novel HA@ceria nanoquantum dots (HA@CQDs) exhibit efficient protective effects against damage induced by ROS. More importantly, aided by H2O2, the HA@CQDs-Ce6/H2O2 significantly enhanced PDT efficacy for the tumor therapy.

Recent Advances in Tumor Microenvironment Hydrogen Peroxide-Responsive Materials for Cancer Photodynamic Therapy

“…In addition, some studies indicated that CeOx NPs oxidase mimics could cause DNA damage, which made them cell killers at low pH. Therefore, Ce-based nanomaterials with the ability of catalase mimics and high tumor selectivity may be a more promising approach to achieve highly efficient PDT for future clinical treatment [45][46][47].…”

Targeted killing of tumor cells based on isoelectric point suitable nanoceria-rod with high oxygen vacancies

“…20,21 In addition, nanoceria could also be designed to enhance chemotherapy, photothermal therapy and photodynamic therapy activity by combining anticancer drugs, photothermal materials and photosensitizers, respectively. 22–25 Therefore, nanoceria has great development potential and clinical application prospects in the treatment of tumors.…”

Biomedical Applications of Bacteria-Derived Polymers

“…Although these sources have generally been successful, renewed scrutiny due to zoonotic infection and incomplete purification methods have led to renewed interest in bacterial fermentation as a route for the manufacturing of HA [ 175 , 176 ]. A benefit during immunoisolation is that bacterial HA as a virulence factor generates a physical barrier to attacking immune cells and the complement system, while reducing the harmful effects of cytotoxic factors, antibiotics, and ROS, reducing the immune system’s ability to mount an effective response [ 177 , 178 , 179 ]. Gunasekaran et al [ 180 ] mentions the use of the capsular HA releasing system in strains of both Streptococcus and Pasteurella species, though the first commercial production of HA was conducted using isolates of Streptococcus zooepidemicus [ 180 , 181 ].…”