Hyaluronic acid-based biopharmaceutical delivery and tumor-targeted drug delivery system

Huang, Gangliang; Huang, Hualiang

doi:10.1016/j.jconrel.2018.04.015

Cited by 253 publications

(135 citation statements)

References 60 publications

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“…Hyaluronic acid as a major role in tissue architecture, tissue regeneration, ingrowth of blood vessels, and cellular functions such as motility, adhesion, and proliferation (Jiang et al, 2011) has been utilized in DDS to improve long-acting and target-specific delivery (Tripodo et al, 2015;Highley et al, 2016;Jiao et al, 2016). In particular, due to the highly specific cellular receptor interaction and cellular uptake of hyaluronic acid in kidney, liver, lymphatic vessels, and tumor sites, hyaluronic acid often has been employed as carriers for intracellular drugs such as anti-tumor agents, and nucleic acids (Oh et al, 2010;Dosio et al, 2016;Lallana et al, 2017;Huang and Huang, 2018;Miyazaki et al, 2018).…”

Section: Polysaccharidesmentioning

confidence: 99%

“…For example, it has been reported that α v β 3 integrin and CD44 receptors are upregulated in various tumor tissues (Danhier et al, 2010). The RGD sequence derived from multiple ECM proteins to target integrin receptors, and hyaluronic acid to target CD44 receptor on cancerous cells, have been widely employed to transport antitumor agents (Murphy et al, 2008;Danhier et al, 2012;Huang and Huang, 2018;Fu et al, 2019). Furthermore, target receptormediated siRNA delivery has been developed utilizing ligands such as peptides, GalNAc, and aptamers (Nikam and Gore, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Targeted Drug Delivery via the Use of ECM-Mimetic Materials

Hwang

Sullivan

Kiick

2020

Front. Bioeng. Biotechnol.

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The use of drug delivery vehicles to improve the efficacy of drugs and to target their action at effective concentrations over desired periods of time has been an active topic of research and clinical investigation for decades. Both synthetic and natural drug delivery materials have facilitated locally controlled as well as targeted drug delivery. Extracellular matrix (ECM) molecules have generated widespread interest as drug delivery materials owing to the various biological functions of ECM. Hydrogels created using ECM molecules can provide not only biochemical and structural support to cells, but also spatial and temporal control over the release of therapeutic agents, including small molecules, biomacromolecules, and cells. In addition, the modification of drug delivery carriers with ECM fragments used as cell-binding ligands has facilitated celltargeted delivery and improved the therapeutic efficiency of drugs through interaction with highly expressed cellular receptors for ECM. The combination of ECM-derived hydrogels and ECM-derived ligand approaches shows synergistic effects, leading to a great promise for the delivery of intracellular drugs, which require specific endocytic pathways for maximal effectiveness. In this review, we provide an overview of cellular receptors that interact with ECM molecules and discuss examples of selected ECM components that have been applied for drug delivery in both local and systemic platforms. Finally, we highlight the potential impacts of utilizing the interaction between ECM components and cellular receptors for intracellular delivery, particularly in tissue regeneration applications.

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Section: Polysaccharidesmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Targeted Drug Delivery via the Use of ECM-Mimetic Materials

Hwang

Sullivan

Kiick

2020

Front. Bioeng. Biotechnol.

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“…This unique behavior has largely encouraged the interest for HyA as drug carriers for targeted drug delivery research, especially for cancer chemotherapy. [9][10][11] The applicability of HyA in drug delivery is however hampered by its great affinity for water and high degradation rate under physiological conditions. HyA has a half-life of about 2-5 min in the bloodstream 12 and its daily turnover in the human body is extremely rapid (in an adult of 70 kg it amounts to about 5 g).…”

Section: Introductionmentioning

confidence: 99%

Comblike Ionic Complexes of Hyaluronic Acid and Alkanoylcholine Surfactants as a Platform for Drug Delivery Systems

et al. 2018

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Nontoxic alkanoylcholine soaps ( nACh) were synthesized from choline and fatty acids with numbers of carbons n equal to 12, 14, 16, and 18, the latter including both saturated and 9- cis unsaturated alkanoyl chains. Coupling of nACh with hyaluronic acid (HyA) rendered comblike ionic complexes nACh·HyA that were non-water-soluble. The complexes were thermally stable up to temperatures above 200 °C but readily degraded by water, in particular when hyaluronidases were present in the aqueous medium. In the solid state, these complexes were self-assembled in a biphasic layered structure in which the surfactant and the polysaccharide phases were alternating regularly with a periodicity dependent on the length of the alkanoyl chain. The paraffinic phase was found to be crystallized in saturated complexes with n ≥ 14, but only 18ACh·HyA showed reversible melting crystallization when subjected to cyclic heating-cooling treatment. Nanoparticles with diameters in the 50-150 nm range were prepared by ionotropic gelation from unbalanced 18ACh·HyA complexes with surfactant:HyA ratios of 0.5 and 0.25. These nanoparticles were also structured in layers, swelled slowly in water, and shown to be noncytotoxic in in vitro assays against macrophages cells. It was also shown that the anticancer drug doxorubicin was efficiently encapsulated in both films and NPs of 18ACh·HyA, and its release was shown to be almost linear and complete after one day of incubation in physiological medium. The nACh·HyA complexes constitute a highly promising biocompatible/biodegradable platform for the design of systems suitable for drug transport and targeting delivery in anticancer chemotherapy.

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“…HA is widely used in anticancer drug delivery, since it is biocompatible, biodegradable, non-toxic, and non-immunogenic, it can be chemically modi-ed to become a good drug carrier. 7,8 For biomedical applications, poly(N-vinylcaprolactam)based (p(VCL)) hydrogel nanoparticles are ideal as they have similar water content to natural tissue. In addition they are one of the most popular thermoresponsive polymers used in the cosmetic industry as their phase transition in response to temperature can be utilized to optimise skin application.…”

mentioning

confidence: 99%