Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin

Özkahraman, Bengi; Emeriewen, Krisztina; Saleh, George M.; Thanh, Nguyễn Thị Kim

doi:10.1039/c9ra06712d

Cited by 7 publications

(2 citation statements)

References 16 publications

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“…10,11 In recent years, hydrogel nanoparticles fabricated by polysaccharides grab substantial attention of formulation scientist as a novel tool for nontoxic delivery of drug molecules through the skin. 12,13 Properties of both hydrogel and Nano architecture are amalgamate in these hydrogel nanoparticles. Among polysaccharides, chitosan (CHS) is cationic polysaccharide serve as a potential carrier for drug delivery due to their favorable intrinsic hydrogel forming properties.…”

Section: Introductionmentioning

confidence: 99%

Emerging role of chondroitin sulfate based nanocarriers in improving the therapeutic outcome of NSAIDs in the treatment of osteoarthritis through the TDDDS

Gul

Jahan

Naseer

2021

JSTMU

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Osteoarthritis is characterized by joint destruction followed by severe inflammation caused by variety of proinflammatory mediators released due to upregulation of nuclear translocation of nuclear factor (NF-kB). Current treatment involves chronic administration of non-steroidal anti-inflammatory drugs (NSAIDs) that is associated with bewildering array of systemic adverse effects. Transdermal drug delivery system address challenges of systemic toxicities but toxic chemical penetration enhancers limit its utility. Novel drug delivery system explores the potential of bio-inspired materials for designing of safe and effective carriers that specifically deliver drug to site of action with enhanced transdermal penetration of the drug. Chondroitin sulfate, a biopolymer that mimic extracellular matrix, binds specifically with its overexpressed receptors (CD44, RHAMM and ICAM-I) at inflammatory site, biodegradable and possess intrinsic anti-inflammatory properties. These attributes render chondroitin sulfate an ideal carrier for the drug delivery in osteoarthritis. Chondroitin sulfate based nanocarriers serve as a potential drug delivery system that not only deliver anti-arthritis drug through the skin but also produce synergistic effect to improve therapeutic outcome. In this review, molecular mechanism of intrinsic anti-inflammatory effects of chondroitin sulfate in osteoarthritis is discussed in detail. Moreover, potential of chondroitin sulfate to perform dual role of therapeutic agent as well as serve as nanocarrier in transdermal drug delivery for the treatment of osteoarthritis is elaborated.

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Section: Introductionmentioning

confidence: 99%

Emerging role of chondroitin sulfate based nanocarriers in improving the therapeutic outcome of NSAIDs in the treatment of osteoarthritis through the TDDDS

Gul

Jahan

Naseer

2021

JSTMU

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“…Hydrogels are a group of hydrophilic polymer networks that show high capacity to retain in their structure large amounts of water or biological fluids, introducing an elastic modulus and swelling while remaining insoluble and maintaining the shape [5][6][7][8]. This makes them good excipients for extended-release tablets wherein the powdered drug is directly mixed with the polymer and compressed to obtain matrix structures.…”

Section: Introductionmentioning

confidence: 99%

Controlled Release of Highly Hydrophilic Drugs from Novel Poly(Magnesium Acrylate) Matrix Tablets

et al. 2020

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The potential of a new poly(magnesium acrylate) hydrogel (PAMgA) as a pharmaceutical excipient for the elaboration of matrix tablets for the extended release of highly hydrophilic drugs was evaluated. The polymer was synthetized with two different crosslinking degrees that were characterized by FTIR and DSC. Their acute oral toxicity was determined in a mouse model, showing no toxicity at doses up to 10 g/kg. Matrix tablets were prepared using metformin hydrochloride as a model drug and the mechanisms involved in drug release (swelling and/or erosion) were investigated using biorrelevant media. This new hydrogel effectively controlled the release of small and highly hydrophilic molecules as metformin, when formulated in matrix tablets for oral administration. The rate of metformin release from PAMgA matrices was mainly controlled by its diffusion through the gel layer (Fickian diffusion). The swelling capacity and the erosion of the matrix tablets influenced the metformin release rate, that was slower at pH 6.8, where polymer swelling is more intensive, than in gastric medium, where matrix erosion is slightly more rapid. The crosslinking degree of the polymer significantly influenced its swelling capacity in acid pH, where swelling is moderate, but not in intestinal fluid, where swelling is more intense.

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Biopolymeric Nanohydrogels As Devices for Controlled and Targeted Delivery of Drugs

Sethi

Medha²,

Thakur³

et al. 2023

Handbook of Green and Sustainable Nanotechnology

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Engineering hydrogel nanoparticles to enhance transdermal local anaesthetic delivery in human eyelid skin

Abstract: Nano-enabled local anaesthetic delivery was achieved using FDA-approved materials with remarkably high loading capacity.

Cited by 7 publications

References 16 publications

Emerging role of chondroitin sulfate based nanocarriers in improving the therapeutic outcome of NSAIDs in the treatment of osteoarthritis through the TDDDS

Emerging role of chondroitin sulfate based nanocarriers in improving the therapeutic outcome of NSAIDs in the treatment of osteoarthritis through the TDDDS

Controlled Release of Highly Hydrophilic Drugs from Novel Poly(Magnesium Acrylate) Matrix Tablets

Biopolymeric Nanohydrogels As Devices for Controlled and Targeted Delivery of Drugs

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