Hyaline membrane disease

Lynch, Matthew; Mellor, Les D.; Badgery, Alan R.; Cameron, Clin

doi:10.1016/s0022-3476(56)80096-6

Cited by 23 publications

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References 25 publications

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“…The association between pulmonary hyaline membranes and intra-alveolar edema in the newborn has been discussed by several authors [3,4,5,7,8,9,10,11,12]. It has been maintained that an increase in the capillary permeability in the pulmonary circulation, possibly secondary to hypoxia, leads to exudation of edematous fluid with a high protein content, which subsequently coagulates to form membranes [9,11,121. In a statistical analysis of the incidence of various pulmonary lesions in the newborn, however, no association has been found between the incidence of pulmonary hyaline membranes and intra-alveolar edema [5] but this is contrary to the findings of many other workers [4, 10, 111.…”

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The Relationship between Hyaline Membranes of the Newborn and the Presence of Other Pulmonary Lesions

Robertson

1963

Acta Paediatrica

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Summary Membrane thickness and associated histologic pulmonary changes were studied in an autopsy series of 117 neonatal deaths presenting pulmonary hyaline membranes. The ages ranged from 6 hours to 7 days. The thickness of the membranes increased with postnatal age, generally reaching a maximum on the third to fourth day. Intra‐alveolar edema was prominent, especially during the first day, and diminished gradually. There was an increasing incidence of complications with age in the form of inflammation and intra‐alveolar hemorrhage.

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confidence: 99%