Pulmonary Hyaline Membranes

Buckingham, Sue

doi:10.1001/archpedi.1960.02070030218012

Cited by 28 publications

(1 citation statement)

References 31 publications

(2 reference statements)

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“…Ayers and Tierney [5] have found no effect of hydrocortisone 40-100 mg/kg/day on the survival of adult rats exposed to normobaric O2, but young (<250g) rats given hydrocortisone lived less and their lungs became heavier when exposed to 100% O2. Buckingham et al [12] have found similar results with 85-95 % O2 exposure.…”

Section: Discussionmentioning

confidence: 61%

Effect of Methyl Prednisolone on Normobaric Pulmonary Oxygen Toxicity in Rats

Halpern¹,

Teitelman²,

Lanir³

1985

Respiration

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Male albino rats were exposed to 81, 86, 90 or 99% oxygen until death. Rats were also administered methyl prednisolone (MP) 10–60 mg/kg/day intraperitoneally. MP-treated rats survived significantly less than controls: 53.5 ± 4.7 vs. 65.2 ± 8.2 h, p < 0.001 in 99% O₂, 74.4 ± 9.4 vs. 120 ± 39.8 h, p < 0.02 in 86% O₂ and 113.7 ± 21.4 vs. 162 ± 17.9 h, p < 0.03 in 81 % O₂. Rats were exposed to 99% O₂ for 10,30 and 50 h and the activity of superoxide dismutase (SOD) and catalase in their lungs was monitored. MP-treated rats showed less increase in pulmonary SOD after 10h (111 vs. 171%, p < 0.03) but no effect on SOD activity thereafter. MP had no effect on the response of catalase to O₂. No effect of MP on lung morphology could be found under the light microscope.

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Section: Discussionmentioning

confidence: 61%

Effect of Methyl Prednisolone on Normobaric Pulmonary Oxygen Toxicity in Rats

Halpern¹,

Teitelman²,

Lanir³

1985

Respiration

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Pulmonary Hyaline Membranes and the Respiratory Distress Syndrome

Gregg¹

1961

Arch Pediatr Adolesc Med

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Pulmonary hyaline membrane: Sites of formation in adult lungs after assisted respiration and inhalation of oxygen

1968

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PULMONARY hyaline membranes are found most commonly in premature infants that show progressively severe respiratory distress and die soon after birth. Accordingly the lesions have so far been studied mainly in infants; but the exact composition of the abnormal material, its mode of formation, and its cause are still unknown.Recent studies (Barter, 1959; Barter and Maddison, 1960) have shown that the membranes are confined predominantly to respiratory bronchioles, but are likely to be related to a more widespread injury to the linings of all the functioning respiratory tissues (Barter, Byrne and Carter, 1966).It is now well known that the membranes also occur in adult lungs and are associated with a variety of diseases (Spencer, 1962; Cederberg, Hellsten and Miorner, 1965; Anderson, 1966). Among the most common of these are uraemia and pulmonary infection; hyaline membranes may also occur after irradiation of the lung. Microscopic examination suggests that the membranes form only a short while before death (Barter et al.). There is a fairly close correlation between the occurrence of these membranes and the clinical picture of severe and progressive respiratory failure.Capers (1961) reported 37 cases of hyaline membranes in adults, and stated that the membranes are brightly eosinophilic strands of delicate laminated material, sometimes closely applied to the alveolar walls. Thirteen of his cases had been treated with oxygen.Recently Nash, Blennerhassett and Pontoppidan (1967) described hyaline membranes in 17 of a study group of 70 cases examinedpost mortem after prolonged mechanical ventilation. They found good correlation between inspiration of high concentrations of oxygen and the presence of the membranes. ., 35, 460. Amer. J. Dis. Child., 99, 216. Amer. J. Med., 31, 701. Actn path. microbiol. scnnd., 64,450. The human lung, New York, pp. 168 The lung, 2nd ed., Springfield, Ill., New Engl. J. Med., 276, 368. Amer. J. Patti., 34, 1033. Pathology of the lung, Oxford, and 171. p. 50. p. 545. Ibid

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Pulmonary Hyaline Membranes

Cited by 28 publications

References 31 publications

Effect of Methyl Prednisolone on Normobaric Pulmonary Oxygen Toxicity in Rats

Effect of Methyl Prednisolone on Normobaric Pulmonary Oxygen Toxicity in Rats

Pulmonary Hyaline Membranes and the Respiratory Distress Syndrome

Pulmonary hyaline membrane: Sites of formation in adult lungs after assisted respiration and inhalation of oxygen

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