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SummaryBirth weight in relation to gestation time, maternal age, parity, and survival have been studied in 123 children with cystic fibrosis and 144 unaffected sibs. These have been compared with the data of Karn & Penrose (1951) for normal infants.It was found that the affected children were significantly fighter than their unaffected sibs. This difference did not appear to be related to differences in maternal age, parity, and gestation.The mean birth weights of the affected children who have died are in general less than of the survivors. Similarly, the mean birth weight of those whose symptoms are primarily duodenal tends to be below average while that of those whose symptoms are primarily pulmonary tends to be above average. Among the unaffected sibs, the mean birth weight of those with sweat sodium levels of 50 m‐equiv./l. or higher was lower than for those with normal levels.The correlation coefficients for affected sib: affected sib was 0.63, for unaffected sib: unaffected sib was 0.53, and for affected sib: unaffected sib was 0–35.The present sample would offer further evidence of genetical factors affecting the growth of the foetus.

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