Human T Lymphotropic Virus 1 and Paracoccidioidomycosis: A Probable Association in Latin America

Leon, Mey; Alave, Jorge; Bustamante, Beatriz; Cok, Jaime; Gotuzzo, Eduardo; Seas, Carlos

doi:10.1086/653679

Cited by 16 publications

(7 citation statements)

References 5 publications

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“…16 Four patients coming from the Peruvian Amazon were diagnosed in Lima-Peru, and in three of them the overall clinical symptoms suggested an underlying case of immunosuppression. This observation alerts for the possibility of the association of both diseases in superimposed endemic areas and also for a probable impact of the co-infection in the evolution of the cases.…”

Section: Epidemiologymentioning

confidence: 99%

Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating

Marques¹

2013

An. Bras. Dermatol.

118

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Paracoccidioidomycosis is an acute - to chronic systemic mycosis caused by fungi of the genus Paracoccidioides. Due to its frequent tegument clinical expression, paracoccidioidomycosis is an important disease for dermatologists, who must be up-to-date about it. This article focuses on recent epidemiological data and discusses the new insights coming from molecular studies, as well as those related to clinical, diagnostic and therapeutic aspects. In the latter section, we give particular attention to the guideline on paracoccidioidomycosis organized by specialists in this subject.

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Section: Epidemiologymentioning

confidence: 99%

Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating

Marques¹

2013

An. Bras. Dermatol.

118

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“…In this patient's case, chronic diarrhea, hematochezia, cervical, histopathological result shows an inflammatory infiltrate, granulomas with epithelioid cells and double-walled giant cells with simple or multiple budding, as well as pseudoepitheliomatous hyperplasia 1,3 . Furthermore, colonoscopy can be used as a complementary exam to diagnose intestinal involvement, in which ulcerations in the mucosa might be observed through visualization of the intestinal lumen 10 . The diagnosis in this case occurred after colonoscopy, when the anatomopathological study allowed confirmation of paracoccidioidomycosis.…”

Section: Discussionmentioning

confidence: 99%

Case report: juvenile paracoccidioidomycosis with intestinal involvement

Da Silva,

Oliveira,

Alves

et al. 2024

Braz. J. Develop.

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Introduction: Contact of Paracoccidioides sp. with the human organism presents in a variety of clinical forms of the disease. Intestinal clinical manifestation is found in 10 to 30% of cases, commonly in juvenile form. This case report seeks to describe a patient with juvenile paracoccidioidomycosis with atypical intestinal involvement. Case report: A 14 years old woman with an updated vaccination schedule and no reports of chronic diseases, allergies or continued use of medications, presented a diarrheal condition that was characterized by pasty stools, where episodes became gradually more intense, associated with episodes of hematochezia, retroauricular lymphadenopathy on the right, as well as shivering and fever. A colonoscopy revealed multiple polypoid formations, ulcerations and friability throughout the colon. After biopsy results, the diagnosis of Paracoccidioidomycosis with intestinal involvement was established. Due to the wasting syndrome, anemia and persistent diarrhea, the patient was hospitalized for blood transfusion and intravenous treatment with conventional Amphotericin B. Discussion: Unlike what was presented by the patient in this case, involvement of the gastrointestinal tract is uncommon in paracoccidioidomycosis. This disease presents a range of clinical manifestations, which makes diagnosis difficult. Since this type of infection is not always considered, it may result in underdiagnosed cases, especially in women and young adults. The prognosis depends on the initial severity of the disease, the presence of comorbidities and the treatment used. Conclusion: Especially for the intestinal form, earlier treatment will better the results. The disease has a good chance of effective treatment using antifungal therapy.

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“…The patients presented general symptoms such as weight loss, diarrhoea, fever, hepatomegaly, dyspnoea and infarcted lymph nodes. PCM‐HIV co‐infection cases could present mixed acute and chronic PCM clinical manifestations and atypical lung lesions 6,36 . In general, when the patient develops PCM due to low CD4+ lymphocyte count, this fungal disease may be the first manifestation of AIDS 6 .…”

Section: Discussionmentioning

confidence: 99%

Oral Paracoccidioidomycosis affecting women: A systematic review

Costa

Carvalho

Sperandio

et al. 2020

Mycoses

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Paracoccidioidomycosis (PCM) is an infection caused by fungi of the genus Paracoccidioides and is marked by a strong predilection for men; nevertheless, some women have had developed PCM and have presented oral involvement by the disease. Objectives: To review all published cases until August 2020 of oral PCM in women, with emphasis on the presence of systemic changes, deleterious habits (tobacco and alcohol) and oral manifestation features through a systematic review. Methods: Observational studies (both prospective and retrospective) and case reports indexed in the Embase, PubMed, Scopus, Web of Science and LIVIVO databases were selected by two reviewers in a two‐phase process following the pre‐established PICOS criteria. Results: Twenty‐five studies met the eligibility criteria and were selected for qualitative synthesis, of which 72 participants were enrolled. Brazilian White women between 40 and 50 years were the most affected and social history revealed them to be housewives or rural workers. Fifteen women (33.3% of the informed cases) presented any systemic change at the time of PCM diagnosis, namely pregnancy, HIV infection and/or depression. Moriform stomatitis was predominant and affected preferentially the gingivae and alveolar processes in the form of a single painful lesion. Most patients were treated with sulfamethoxazole + trimethoprim or itraconazole. Conclusions: Oral PCM in women is rare; some cases showed systemic changes at the time of PCM diagnosis, namely HIV infection, pregnancy and depression. New studies should be conducted to elucidate the influence of systemic alterations on the development of oral PCM in women.

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Human T Lymphotropic Virus 1 and Paracoccidioidomycosis: A Probable Association in Latin America

Cited by 16 publications

References 5 publications

Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating

Paracoccidioidomycosis: epidemiological, clinical, diagnostic and treatment up-dating

Case report: juvenile paracoccidioidomycosis with intestinal involvement

Oral Paracoccidioidomycosis affecting women: A systematic review

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