Human serum albumin-based propulsive Piperlongumine-loaded nanoparticles: Formulation development, characterization and anti-cancer study

Patel, Krunal; Jain, Poonam; Rajput, Pradeep Kumar; Jangid, Ashok Kumar; Solanki, Raghu; Kulhari, Hitesh; Patel, Sunita

doi:10.1016/j.colsurfa.2022.129738

Cited by 13 publications

(6 citation statements)

References 41 publications

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“… 8 Due to the benefits, such as high drug delivery capacity, targeting ability, strong stability, good biocompatibility, long half-life, and simple purification procedure, HSA has received significant attention recently as a drug carrier. 24 , 25 …”

Section: Methodsmentioning

confidence: 99%

Factors Affecting the Synthesis of Bovine Serum Albumin Nanoparticles Using the Desolvation Method

Tanjung,

Dewi,

Gatera

et al. 2024

NSA

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Currently, protein-based nanoparticles are in high demand as drug delivery systems due to their exceptional qualities, including nontoxicity, nonantigenicity, and biodegradability. Other qualities include high nutritional value, abundance of renewable resources, excellent drug binding capacity, greater stability during storage and in vivo, as well as ease of upgrading during manufacture. Examples of protein suitable for this purpose include ovalbumin (OVA) derived from egg white, human serum albumin (HSA), and bovine serum albumin (BSA). To create albumin nanoparticles, six different processes have been investigated in depth and are frequently used in drug delivery systems. These included desolvation, thermal gelation, emulsification, NAB technology, self-assembly, and nanospray drying. Several experimental conditions in the synthesis of albumin nanoparticles can affect the physicochemical characterization. Therefore, this study aimed to provide an overview of various experimental conditions capable of affecting the physicochemical characteristics of BSA nanoparticles formed using the desolvation method. By considering the variation in optimal experimental conditions, a delivery system of BSA nanoparticles with the best physicochemical characterization results could be developed.

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Section: Methodsmentioning

confidence: 99%

Factors Affecting the Synthesis of Bovine Serum Albumin Nanoparticles Using the Desolvation Method

Tanjung,

Dewi,

Gatera

et al. 2024

NSA

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“…Therefore, real time qRT-PCR was performed to assess the apoptotic gene expression in HeLa cancer cell line as previously reported study. [73] For that, HeLa cells were grown and incubated with BNMs, Evo, and ENMs for 24 h. After completion of treatment, total RNA was extracted from treated cells using TRIzol method (according to manufactures instructions). Then, cDNA synthesis was performed using the Prime Script cDNA synthesis kit provided by Bio-Rad.…”

Section: Methodsmentioning

confidence: 99%

Folate Functionalized and Evodiamine‐Loaded Pluronic Nanomicelles for Augmented Cervical Cancer Cell Killing

Solanki

Jangid

Jadav

et al. 2023

Macromolecular Bioscience

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Evodiamine (Evo) is a natural, biologically active plant alkaloid with wide range of pharmacological activities. In the present study Evo‐loaded folate‐conjugated Pluronic F108 nano‐micelles (ENM) is synthesized to enhance the therapeutic efficacy of Evo against cervical cancer. ENM are synthesized, physicochemically characterized and in vitro anticancer activity is performed. The study demonstrates that ENM have nanoscale size (50.33 ± 3.09 nm), monodispersity of 0.122 ± 0.072, with high drug encapsulation efficiency (71.30 ± 3.76%) and controlled drug release at the tumor microenvironment. ENM showed dose‐dependent and time‐dependent cytotoxicity against HeLa human cervical cancer cells. The results of in vitro anticancer studies demonstrated that ENM have significant anticancer effects and greatly induce apoptosis as compared to pure Evo. The cellular uptake study suggests that increased anticancer activity of ENM is due to the improved intracellular delivery of Evo through overexpressed folate receptors. Overall, the designed ENM can be a potential targeted delivery system for hydrophobic anticancer bioactive compound like Evo.

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“…In addition to these two specified drug-binding domains, HSA molecule exhibited other drug binding strategies including electrostatic interaction as well as hydrophobic interaction ( Iqbal et al, 2021 ; Wang et al, 2023 ). Various kinds of cytotoxic agents ( Zhang et al, 2018 ; Motevalli et al, 2019 ), anti-inflammatory agents ( Czub and Handing, 2020 ; Spada et al, 2021 ) hypoglycemic agents ( Lu et al, 2020 ; Jose et al, 2015 ), carbohydrates ( Wang et al, 2024 ) and other drugs ( Mickaela Martinez et al, 2022 ; Patel et al, 2022 )might have high affinity to bind to albumin, thereby improving their pharmacokinetics and therapeutic efficiencies with reduced adverse side effects. Usually, therapeutic drug molecules interact with albumin either through electrostatic, hydrophobic interaction or specific binding domain to generate albumin-drug conjugates or nanoparticles with nanometers size ( Hassanin and Elzoghby, 2020 ; Pal et al, 2023 ).…”

Section: Protein Nanocarriersmentioning

confidence: 99%

Rationalized landscape on protein-based cancer nanomedicine: Recent progress and challenges

Fan,

Iqbal,

et al. 2024

International Journal of Pharmaceutics: X

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Human serum albumin-based propulsive Piperlongumine-loaded nanoparticles: Formulation development, characterization and anti-cancer study

Cited by 13 publications

References 41 publications

Factors Affecting the Synthesis of Bovine Serum Albumin Nanoparticles Using the Desolvation Method

Factors Affecting the Synthesis of Bovine Serum Albumin Nanoparticles Using the Desolvation Method

Folate Functionalized and Evodiamine‐Loaded Pluronic Nanomicelles for Augmented Cervical Cancer Cell Killing

Rationalized landscape on protein-based cancer nanomedicine: Recent progress and challenges

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