Human scFvs That Counteract Bioactivities of Staphylococcus aureus TSST-1

Rukkawattanakul, Thunchanok; Sookrung, Nitat; Seesuay, Watee; Onlamoon, Nattawat; Diraphat, Pornphan; Chaicumpa, Wanpen; Indrawattana, Nitaya

doi:10.3390/toxins9020050

Cited by 17 publications

(24 citation statements)

References 46 publications

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“…Since raw fish is consumed in many countries, there is a risk of disease transmission to humans (Oh et al 2019 ). Skin infection by S. aureus may lead to toxic shock syndrome (TSS) due to the bacterial TSST-1 toxin which is regarded as a super antigen that enters the blood stream and activates polyclonal T cells in peripheral blood causing massive release of pro-inflammatory cytokines (Rukkawattanakul et al 2017 ).…”

Section: Bacterial Zoonotic Agentsmentioning

confidence: 99%

Zoonotic diseases of fish and their prevention and control

Ziarati

Zorriehzahra

Hassantabar

et al. 2022

Veterinary Quarterly

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Fish and aquatic-derived zoonotic diseases have caused considerable problems in the aquaculture industry and fishery worldwide. In particular, zoonotic diseases can pose widespread threats to humans. With the world’s growing population and potential global trade of aquaculture and fish, the risk of environmental contamination and development of fish and aquatic-derived zoonoses in humans are increasing. The important causes of zoonoses include bacteria, parasites, viruses, and fungi. The zoonotic bacterial agents are divided into two main groups: Gram-positive ( Mycobacteriaceae , Streptococcaceae , Erysipelothricaceae families) and Gram-negative ( Aeromonadaceae , Vibrionaceae , Pseudomondaceae , Enterobacteriaceae , and Hafniaceae families). The premier parasitic agents include cestodes (tapeworm; e.g. Diphyllobothrium spp.), trematodes (fluke; e.g. Opisthorchis spp.), and nematodes (round worm; e.g. Anisakis spp.). In addition, protozoan organisms such as Cryptosporidium spp. are also considered fish-derived zoonotic pathogens. Two groups of fish-associated fungi causing basidiobolomycosis and sporotrichosis also pose a zoonotic risk for humans. The majority of the fish-derived zoonotic diseases are transmitted to humans mainly via the consumption of improperly cooked or raw fish or fish products. Therefore, the incidence of zoonotic diseases can be reduced by properly processing fish and fish products, e.g. by thermal (heat/freezing) treatment. The prevalence of zoonotic agents in fishes varies seasonally and should be regularly monitored to evaluate the prevalence of pathogens in both wild and cultured fish populations. This review focuses on the fish zoonotic agents/diseases and their control and prevention.

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Section: Bacterial Zoonotic Agentsmentioning

confidence: 99%

Zoonotic diseases of fish and their prevention and control

Ziarati

Zorriehzahra

Hassantabar

et al. 2022

Veterinary Quarterly

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“…Prophylactic treatment with a combination of two mAbs, named 4G3 and 5G4, that recognize different epitopes on staphylococcal enterotoxin K (SEK) significantly enhanced the survival of mice in a model of SEK-induced lethal shock and sepsis by a virulent staphylococcal strain [ 98 ] ( Table 1 ). Human monoclonal single-chain antibodies (scFvs) against TSST-1 blocked the activation and proliferation of T cells and the secretion of pro-inflammatory cytokines, suggesting their possible therapeutic application in infective syndromes involving this important superantigen [ 115 ].…”

Section: Mabs Targeting Virulence Factors and Their Possible Therapeutic Use To Combat Staphylococcal Infectionsmentioning

confidence: 99%

Monoclonal Antibodies Targeting Surface-Exposed and Secreted Proteins from Staphylococci

Speziale

Pietrocola

2021

Vaccines

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Staphylococci (specifically Staphylococcus aureus and Staphylococcus epidermidis) are the causative agents of diseases ranging from superficial skin and soft tissue infections to severe conditions such as fatal pneumonia, bacteremia, sepsis and endocarditis. The widespread and indiscriminate use of antibiotics has led to serious problems of resistance to staphylococcal disease and has generated a renewed interest in alternative therapeutic agents such as vaccines and antibodies. Staphylococci express a large repertoire of surface and secreted virulence factors, which provide mechanisms (adhesion, invasion and biofilm development among others) for both bacterial survival in the host and evasion from innate and adaptive immunity. Consequently, the development of antibodies that target specific antigens would provide an effective protective strategy against staphylococcal infections. In this review, we report an update on efforts to develop anti-staphylococci monoclonal antibodies (and their derivatives: minibodies, antibody–antibiotic conjugates) and the mechanism by which such antibodies can help fight infections. We also provide an overview of mAbs used in clinical trials and highlight their therapeutic potential in various infectious contexts.

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“…TSST-1 causes proliferation of peripheral blood T lymphocytes and release of huge amounts of pro-inflammatory cytokines resulting in a life-threatening disease known as toxic shock syndrome (TSS). Binding of scFvs to TSST-1 inhibited activation and proliferation of T cells and secretion of pro-inflammatory cytokines, suggesting their potential therapeutic application against TSS [ 109 ]. In confirmation of the value and possible use of anti-TSST-1 antibodies as therapeutic agent, Kansal et al also demonstrated that high levels of anti-TSST-1 antibodies significantly protect women against menstrual toxic shock syndrome [ 110 ].…”

Section: Antibodies In Bacterial Infectionsmentioning

confidence: 99%

Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus Diseases

2018

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Staphylococcus aureus is a human pathogen that can cause a wide spectrum of diseases, including sepsis, pneumonia, arthritis, and endocarditis. Ineffective treatment of a number of staphylococcal infections with antibiotics is due to the development and spread of antibiotic-resistant strains following decades of antibiotic usage. This has generated renewed interest within the scientific community in alternative therapeutic agents, such as anti-S. aureus antibodies. Although the role of antibodies in the management of S. aureus diseases is controversial, the success of this pathogen in neutralizing humoral immunity clearly indicates that antibodies offer the host extensive protection. In this review, we report an update on efforts to develop antibody-based agents, particularly monoclonal antibodies, and their therapeutic potential in the passive immunization approach to the treatment and prevention of S. aureus infections.

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Human scFvs That Counteract Bioactivities of Staphylococcus aureus TSST-1

Cited by 17 publications

References 46 publications

Zoonotic diseases of fish and their prevention and control

Zoonotic diseases of fish and their prevention and control

Monoclonal Antibodies Targeting Surface-Exposed and Secreted Proteins from Staphylococci

Antibody-Based Agents in the Management of Antibiotic-Resistant Staphylococcus aureus Diseases

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