Human reagins: appraisal of the properties of the antibody of immediate-type hypersensitivity.

Flick, J A

doi:10.1128/mmbr.36.3.311-360.1972

Cited by 3 publications

(3 citation statements)

References 185 publications

(253 reference statements)

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“…Furthermore the intensity of the PK test was also related to the concentration of serum IgE (Table 5) as previously reported by Flick (1972).…”

Section: Discussionsupporting

confidence: 76%

“…A good, but not exact correlation has been said to occur between serum reagin and skin test reactivity (Flick, 1972). We found (Table 4) that the mean serum IgE concentration (2927 iu/ml) in twenty-two patients who did not respond to intradermal tests with allergens was significantly lower than that (4214 iu/ml) observed in fortyseven such cases who showed positive intradermal tests (; = 2-37).…”

Section: Discussionmentioning

confidence: 76%

“…Our results show that the PK test is the most sensitive and reliable in vivo method of detecting reagins and correlated well with the intradermal test on the serum donors; the bronchial and conjunctival tests are much less sensitive (Table 7). Flick (1972) stated that the intradermal test was the most sensitive technique though sometimes there are false positive reactions. There is also a good correlation between severity of asthma and intensity of the PK reaction (Table 8), though not in all persons, and indicates a possibility of mediators other than reagins inducing bronchoconstrictions after inhaling allergens to which the persons were sensitized (Warwick, 1971).…”

Section: Discussionmentioning

confidence: 99%

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A study of serum immunoglobulins including IgE and reaginic antibodies in patients with bronchial asthma in relation to the spectrum of the disease

Saha

Kulpati

Padmini

et al. 1975

Clin Experimental Allergy

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Summary Immunoglobulins G, A, M, D, and E were studied in the sera obtained from sixty‐nine bronchial asthma patients, who were graded objectively according to atopic score. Among other associated atopic diseases, they often had allergic rhinitis. Ninety‐one per cent of these patients had elevated serum IgE levels and the mean level of serum IgE was more than 3.5 times higher than that observed in the normal subjects. Moreover, as their atopic score increased, the serum IgE levels were also elevated, and every patient with high atopic score, had elevated serum IgE levels: This indicates the association of atopic state with serum IgE level. Furthermore, reaginic antibodies were studied in some of these patients by intradermal tests, Prausnitz‐Küstner (PK) reaction, conjunctival and bronchial provocation tests. Intradermal and PK tests were comparable and proved to be the most sensitive method of detecting reagins. The intensity of these reactions correlated significantly with serum IgE level, although this relationship is not invariably present. The reaginic activities in the sera of the patients with atopic bronchial asthma also compared well with the positive bronchial test (induced asthma) by inhalation of specific aerosol although this association is also not always present. Eleven patients with high atopic score had isolated serum IgA deficiency. There was a significant rise of mean serum IgM in comparison to the controls.

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“…Furthermore the intensity of the PK test was also related to the concentration of serum IgE (Table 5) as previously reported by Flick (1972).…”

Section: Discussionsupporting

confidence: 76%

Section: Discussionmentioning

confidence: 76%

Section: Discussionmentioning

confidence: 99%

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